Influence of Bariatric Surgery on Erectile Dysfunction—a Systematic Review and Meta-Analysis
Introduction Obesity is associated with a higher prevalence of various comorbidities including erectile dysfunction (ED). Bariatric surgery leads to weight loss and remission of weight-related diseases. The exact influence of bariatric treatment on ED is yet to be established; however, the number of...
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| Veröffentlicht in: | Obesity surgery 2023-06, Vol.33 (6), p.1652-1658 |
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| creator | Małczak, Piotr Wysocki, Michał Pisarska-Adamczyk, Magdalena Strojek, Jakub Rodak, Hanna Lastovetskyi, Ilie Pędziwiatr, Michał Major, Piotr |
| description | Introduction
Obesity is associated with a higher prevalence of various comorbidities including erectile dysfunction (ED). Bariatric surgery leads to weight loss and remission of weight-related diseases. The exact influence of bariatric treatment on ED is yet to be established; however, the number of papers on the subject is growing.
Methodology
A systematic review with meta-analysis comparing erectile dysfunction before and after surgery was conducted according to PRISMA guidelines with a literature search performed in June 2022. Inclusion criteria involved (1) ED assessment using the International International Index of Erectile Function (IIEF) and (2) longitudinal study design. Secondary endpoints involved hormonal changes and specific fields of IIEF.
Results
An initial search yielded 878 records. Fourteen studies were included in the meta-analysis involving 508 patients. The quality of analyzed studies was moderate. Analysis showed significant differences in IIEF before and after surgery (Std. MD = 1.19, 95% CI 0.72 to 1.66,
p |
| doi_str_mv | 10.1007/s11695-023-06572-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10234872</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2805028787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-b1c1cdee55e6bc49364fd18129360f12829b338924e5029bee026754d0efe1893</originalsourceid><addsrcrecordid>eNp9kU1uFDEQhS0EIkPgAiyQJTZsDGX3n71CIQSIFIREYIvlcVcHRz12YncH9Y5DcEJOQg0Tws-CjV1SfX5Vz4-xhxKeSoDuWZGyNY0AVQlom04Jc4utZAdaQK30bbYC04LQRlV77F4p5wBKtkrdZXsVQS0dK_bpOA7jjNEjTwN_4XJwUw6en875DPPCU-RHGf0URuQvlzLMkeoUv3_95vjpUibcuInw93gV8At3sedvcXLiILpxKaHcZ3cGNxZ8cH3vs4-vjj4cvhEn714fHx6cCF93zSTW0kvfIzYNtmtfm6qth15qqaiCQSqtzLqqyEmNDVCNCKrtmroHHFBqU-2z5zvdi3m9wd5jnLIb7UUOG5cXm1ywf3di-GzP0pWV9Hu17hQpPLlWyOlyxjLZTSgex9FFTHOxSgON1p3uCH38D3qe5kyOt5SStTFKaqLUjvI5lZJxuNlGgt3mZ3f5WdrA_szPbn08-tPHzZNfgRFQ7YBCrUgR_Z79H9kfK_GnSQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2821499218</pqid></control><display><type>article</type><title>Influence of Bariatric Surgery on Erectile Dysfunction—a Systematic Review and Meta-Analysis</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Małczak, Piotr ; Wysocki, Michał ; Pisarska-Adamczyk, Magdalena ; Strojek, Jakub ; Rodak, Hanna ; Lastovetskyi, Ilie ; Pędziwiatr, Michał ; Major, Piotr</creator><creatorcontrib>Małczak, Piotr ; Wysocki, Michał ; Pisarska-Adamczyk, Magdalena ; Strojek, Jakub ; Rodak, Hanna ; Lastovetskyi, Ilie ; Pędziwiatr, Michał ; Major, Piotr</creatorcontrib><description>Introduction
Obesity is associated with a higher prevalence of various comorbidities including erectile dysfunction (ED). Bariatric surgery leads to weight loss and remission of weight-related diseases. The exact influence of bariatric treatment on ED is yet to be established; however, the number of papers on the subject is growing.
Methodology
A systematic review with meta-analysis comparing erectile dysfunction before and after surgery was conducted according to PRISMA guidelines with a literature search performed in June 2022. Inclusion criteria involved (1) ED assessment using the International International Index of Erectile Function (IIEF) and (2) longitudinal study design. Secondary endpoints involved hormonal changes and specific fields of IIEF.
Results
An initial search yielded 878 records. Fourteen studies were included in the meta-analysis involving 508 patients. The quality of analyzed studies was moderate. Analysis showed significant differences in IIEF before and after surgery (Std. MD = 1.19, 95% CI 0.72 to 1.66,
p
<0.0001). Testosterone after surgery is higher by 156.32 pg/ml (95% CI 84.78 to 227.86,
p
<0.0001). There were differences in erectile function (MD:4.86,
p
< 0.0001), desire (MD: 1.21,
p
< 0.0001), intercourse satisfaction (MD: 2.16,
p
< 0.0001), and overall satisfaction (MD: 1.21,
p
= 0.003). There were no differences in terms of orgasms (MD: 0.65,
p
= 0.06).
Conclusion
There are differences in ED before and after bariatric surgery. Patients achieve 19% more in the IIEF questionnaire showing improvement. Further studies, including multivariate regression models on large cohorts, are required to determine whether the surgery is an independent factor in alleviating ED.
Graphical Abstract</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-023-06572-9</identifier><identifier>PMID: 37086370</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bariatric Surgery ; Erectile dysfunction ; Erectile Dysfunction - epidemiology ; Erectile Dysfunction - etiology ; Gastrointestinal surgery ; Humans ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Meta-analysis ; Obesity, Morbid - surgery ; Original Contributions ; Penile Erection ; Surgery ; Systematic review</subject><ispartof>Obesity surgery, 2023-06, Vol.33 (6), p.1652-1658</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-b1c1cdee55e6bc49364fd18129360f12829b338924e5029bee026754d0efe1893</citedby><cites>FETCH-LOGICAL-c475t-b1c1cdee55e6bc49364fd18129360f12829b338924e5029bee026754d0efe1893</cites><orcidid>0000-0001-8936-1977</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-023-06572-9$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-023-06572-9$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37086370$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Małczak, Piotr</creatorcontrib><creatorcontrib>Wysocki, Michał</creatorcontrib><creatorcontrib>Pisarska-Adamczyk, Magdalena</creatorcontrib><creatorcontrib>Strojek, Jakub</creatorcontrib><creatorcontrib>Rodak, Hanna</creatorcontrib><creatorcontrib>Lastovetskyi, Ilie</creatorcontrib><creatorcontrib>Pędziwiatr, Michał</creatorcontrib><creatorcontrib>Major, Piotr</creatorcontrib><title>Influence of Bariatric Surgery on Erectile Dysfunction—a Systematic Review and Meta-Analysis</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Introduction
Obesity is associated with a higher prevalence of various comorbidities including erectile dysfunction (ED). Bariatric surgery leads to weight loss and remission of weight-related diseases. The exact influence of bariatric treatment on ED is yet to be established; however, the number of papers on the subject is growing.
Methodology
A systematic review with meta-analysis comparing erectile dysfunction before and after surgery was conducted according to PRISMA guidelines with a literature search performed in June 2022. Inclusion criteria involved (1) ED assessment using the International International Index of Erectile Function (IIEF) and (2) longitudinal study design. Secondary endpoints involved hormonal changes and specific fields of IIEF.
Results
An initial search yielded 878 records. Fourteen studies were included in the meta-analysis involving 508 patients. The quality of analyzed studies was moderate. Analysis showed significant differences in IIEF before and after surgery (Std. MD = 1.19, 95% CI 0.72 to 1.66,
p
<0.0001). Testosterone after surgery is higher by 156.32 pg/ml (95% CI 84.78 to 227.86,
p
<0.0001). There were differences in erectile function (MD:4.86,
p
< 0.0001), desire (MD: 1.21,
p
< 0.0001), intercourse satisfaction (MD: 2.16,
p
< 0.0001), and overall satisfaction (MD: 1.21,
p
= 0.003). There were no differences in terms of orgasms (MD: 0.65,
p
= 0.06).
Conclusion
There are differences in ED before and after bariatric surgery. Patients achieve 19% more in the IIEF questionnaire showing improvement. Further studies, including multivariate regression models on large cohorts, are required to determine whether the surgery is an independent factor in alleviating ED.
Graphical Abstract</description><subject>Bariatric Surgery</subject><subject>Erectile dysfunction</subject><subject>Erectile Dysfunction - epidemiology</subject><subject>Erectile Dysfunction - etiology</subject><subject>Gastrointestinal surgery</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Obesity, Morbid - surgery</subject><subject>Original Contributions</subject><subject>Penile Erection</subject><subject>Surgery</subject><subject>Systematic review</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU1uFDEQhS0EIkPgAiyQJTZsDGX3n71CIQSIFIREYIvlcVcHRz12YncH9Y5DcEJOQg0Tws-CjV1SfX5Vz4-xhxKeSoDuWZGyNY0AVQlom04Jc4utZAdaQK30bbYC04LQRlV77F4p5wBKtkrdZXsVQS0dK_bpOA7jjNEjTwN_4XJwUw6en875DPPCU-RHGf0URuQvlzLMkeoUv3_95vjpUibcuInw93gV8At3sedvcXLiILpxKaHcZ3cGNxZ8cH3vs4-vjj4cvhEn714fHx6cCF93zSTW0kvfIzYNtmtfm6qth15qqaiCQSqtzLqqyEmNDVCNCKrtmroHHFBqU-2z5zvdi3m9wd5jnLIb7UUOG5cXm1ywf3di-GzP0pWV9Hu17hQpPLlWyOlyxjLZTSgex9FFTHOxSgON1p3uCH38D3qe5kyOt5SStTFKaqLUjvI5lZJxuNlGgt3mZ3f5WdrA_szPbn08-tPHzZNfgRFQ7YBCrUgR_Z79H9kfK_GnSQ</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Małczak, Piotr</creator><creator>Wysocki, Michał</creator><creator>Pisarska-Adamczyk, Magdalena</creator><creator>Strojek, Jakub</creator><creator>Rodak, Hanna</creator><creator>Lastovetskyi, Ilie</creator><creator>Pędziwiatr, Michał</creator><creator>Major, Piotr</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8936-1977</orcidid></search><sort><creationdate>20230601</creationdate><title>Influence of Bariatric Surgery on Erectile Dysfunction—a Systematic Review and Meta-Analysis</title><author>Małczak, Piotr ; Wysocki, Michał ; Pisarska-Adamczyk, Magdalena ; Strojek, Jakub ; Rodak, Hanna ; Lastovetskyi, Ilie ; Pędziwiatr, Michał ; Major, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-b1c1cdee55e6bc49364fd18129360f12829b338924e5029bee026754d0efe1893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bariatric Surgery</topic><topic>Erectile dysfunction</topic><topic>Erectile Dysfunction - epidemiology</topic><topic>Erectile Dysfunction - etiology</topic><topic>Gastrointestinal surgery</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meta-analysis</topic><topic>Obesity, Morbid - surgery</topic><topic>Original Contributions</topic><topic>Penile Erection</topic><topic>Surgery</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Małczak, Piotr</creatorcontrib><creatorcontrib>Wysocki, Michał</creatorcontrib><creatorcontrib>Pisarska-Adamczyk, Magdalena</creatorcontrib><creatorcontrib>Strojek, Jakub</creatorcontrib><creatorcontrib>Rodak, Hanna</creatorcontrib><creatorcontrib>Lastovetskyi, Ilie</creatorcontrib><creatorcontrib>Pędziwiatr, Michał</creatorcontrib><creatorcontrib>Major, Piotr</creatorcontrib><collection>Springer Nature OA/Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Małczak, Piotr</au><au>Wysocki, Michał</au><au>Pisarska-Adamczyk, Magdalena</au><au>Strojek, Jakub</au><au>Rodak, Hanna</au><au>Lastovetskyi, Ilie</au><au>Pędziwiatr, Michał</au><au>Major, Piotr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Bariatric Surgery on Erectile Dysfunction—a Systematic Review and Meta-Analysis</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>33</volume><issue>6</issue><spage>1652</spage><epage>1658</epage><pages>1652-1658</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Introduction
Obesity is associated with a higher prevalence of various comorbidities including erectile dysfunction (ED). Bariatric surgery leads to weight loss and remission of weight-related diseases. The exact influence of bariatric treatment on ED is yet to be established; however, the number of papers on the subject is growing.
Methodology
A systematic review with meta-analysis comparing erectile dysfunction before and after surgery was conducted according to PRISMA guidelines with a literature search performed in June 2022. Inclusion criteria involved (1) ED assessment using the International International Index of Erectile Function (IIEF) and (2) longitudinal study design. Secondary endpoints involved hormonal changes and specific fields of IIEF.
Results
An initial search yielded 878 records. Fourteen studies were included in the meta-analysis involving 508 patients. The quality of analyzed studies was moderate. Analysis showed significant differences in IIEF before and after surgery (Std. MD = 1.19, 95% CI 0.72 to 1.66,
p
<0.0001). Testosterone after surgery is higher by 156.32 pg/ml (95% CI 84.78 to 227.86,
p
<0.0001). There were differences in erectile function (MD:4.86,
p
< 0.0001), desire (MD: 1.21,
p
< 0.0001), intercourse satisfaction (MD: 2.16,
p
< 0.0001), and overall satisfaction (MD: 1.21,
p
= 0.003). There were no differences in terms of orgasms (MD: 0.65,
p
= 0.06).
Conclusion
There are differences in ED before and after bariatric surgery. Patients achieve 19% more in the IIEF questionnaire showing improvement. Further studies, including multivariate regression models on large cohorts, are required to determine whether the surgery is an independent factor in alleviating ED.
Graphical Abstract</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37086370</pmid><doi>10.1007/s11695-023-06572-9</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8936-1977</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity surgery, 2023-06, Vol.33 (6), p.1652-1658 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Bariatric Surgery Erectile dysfunction Erectile Dysfunction - epidemiology Erectile Dysfunction - etiology Gastrointestinal surgery Humans Longitudinal Studies Male Medicine Medicine & Public Health Meta-analysis Obesity, Morbid - surgery Original Contributions Penile Erection Surgery Systematic review |
| title | Influence of Bariatric Surgery on Erectile Dysfunction—a Systematic Review and Meta-Analysis |
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