Barrier-environment interactions along the gut-brain axis and their influence on cognition and behaviour throughout the lifespan
Environment is known to substantially alter mental state and behaviour across the lifespan. Biological barriers such as the blood-brain barrier (BBB) and gut barrier (GB) are major hubs for communication of environmental information. Alterations in the structural, social and motor environment at dif...
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| Veröffentlicht in: | Journal of psychiatry & neuroscience 2023-05, Vol.48 (3), p.E190-E208 |
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| creator | Paton, Sam E J Solano, José L Coulombe-Rozon, François Lebel, Manon Menard, Caroline |
| description | Environment is known to substantially alter mental state and behaviour across the lifespan. Biological barriers such as the blood-brain barrier (BBB) and gut barrier (GB) are major hubs for communication of environmental information. Alterations in the structural, social and motor environment at different stages of life can influence function of the BBB and GB and their integrity to exert behavioural consequences. Importantly, each of these environmental components is associated with a distinct immune profile, glucocorticoid response and gut microbiome composition, creating unique effects on the BBB and GB. These barrier-environment interactions are sensitive to change throughout life, and positive or negative alterations at critical stages of development can exert long-lasting cognitive and behavioural consequences. Furthermore, because loss of barrier integrity is implicated in pathogenesis of mental disorders, the pathways of environmental influence represent important areas for understanding these diseases. Positive environments can be protective against stress- and age-related damage, raising the possibility of novel pharmacological targets. This review summarizes known mechanisms of environmental influence - such as social interactions, structural complexity and physical exercise - on barrier composition, morphology and development, and considers the outcomes and implications of these interactions in the context of psychiatric disorders. |
| doi_str_mv | 10.1503/jpn.220218 |
| format | Article |
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Biological barriers such as the blood-brain barrier (BBB) and gut barrier (GB) are major hubs for communication of environmental information. Alterations in the structural, social and motor environment at different stages of life can influence function of the BBB and GB and their integrity to exert behavioural consequences. Importantly, each of these environmental components is associated with a distinct immune profile, glucocorticoid response and gut microbiome composition, creating unique effects on the BBB and GB. These barrier-environment interactions are sensitive to change throughout life, and positive or negative alterations at critical stages of development can exert long-lasting cognitive and behavioural consequences. Furthermore, because loss of barrier integrity is implicated in pathogenesis of mental disorders, the pathways of environmental influence represent important areas for understanding these diseases. Positive environments can be protective against stress- and age-related damage, raising the possibility of novel pharmacological targets. This review summarizes known mechanisms of environmental influence - such as social interactions, structural complexity and physical exercise - on barrier composition, morphology and development, and considers the outcomes and implications of these interactions in the context of psychiatric disorders.</description><identifier>ISSN: 1180-4882</identifier><identifier>ISSN: 1488-2434</identifier><identifier>EISSN: 1488-2434</identifier><identifier>DOI: 10.1503/jpn.220218</identifier><identifier>PMID: 37253482</identifier><language>eng</language><publisher>Canada: CMA Impact Inc</publisher><subject>Age ; Blood vessels ; Blood-brain barrier ; Blood-Brain Barrier - metabolism ; Blood-Brain Barrier - pathology ; Brain - metabolism ; Brain-Gut Axis ; Cognition ; Cognition & reasoning ; Cognitive ability ; Communication ; Corticosteroids ; Cytokines ; Developmental stages ; Disease ; Environmental aspects ; Environmental conditions ; Environmental information ; Exercise ; Gene-Environment Interaction ; Genomes ; Glucocorticoids ; Homeostasis ; Humans ; Immune system ; Intestinal microflora ; Laboratories ; Life span ; Longevity ; Mental disorders ; Mental illness ; Metabolites ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Morphology ; Pathogenesis ; Permeability ; Proteins ; Review Paper ; Risk factors ; Social aspects ; Social behavior ; Social interactions ; Socioeconomic factors ; Tumor necrosis factor-TNF</subject><ispartof>Journal of psychiatry & neuroscience, 2023-05, Vol.48 (3), p.E190-E208</ispartof><rights>2023 CMA Impact Inc. or its licensors.</rights><rights>COPYRIGHT 2023 CMA Impact Inc.</rights><rights>2023. This work is published under https://jpn.ca/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 CMA Impact Inc. or its licensors 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-c7f1c6aba8b35dc3728bb6e82d7a41746c285873f5ac5fa9b977a23f804bf983</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234620/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234620/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37253482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paton, Sam E J</creatorcontrib><creatorcontrib>Solano, José L</creatorcontrib><creatorcontrib>Coulombe-Rozon, François</creatorcontrib><creatorcontrib>Lebel, Manon</creatorcontrib><creatorcontrib>Menard, Caroline</creatorcontrib><title>Barrier-environment interactions along the gut-brain axis and their influence on cognition and behaviour throughout the lifespan</title><title>Journal of psychiatry & neuroscience</title><addtitle>J Psychiatry Neurosci</addtitle><description>Environment is known to substantially alter mental state and behaviour across the lifespan. Biological barriers such as the blood-brain barrier (BBB) and gut barrier (GB) are major hubs for communication of environmental information. Alterations in the structural, social and motor environment at different stages of life can influence function of the BBB and GB and their integrity to exert behavioural consequences. Importantly, each of these environmental components is associated with a distinct immune profile, glucocorticoid response and gut microbiome composition, creating unique effects on the BBB and GB. These barrier-environment interactions are sensitive to change throughout life, and positive or negative alterations at critical stages of development can exert long-lasting cognitive and behavioural consequences. Furthermore, because loss of barrier integrity is implicated in pathogenesis of mental disorders, the pathways of environmental influence represent important areas for understanding these diseases. Positive environments can be protective against stress- and age-related damage, raising the possibility of novel pharmacological targets. This review summarizes known mechanisms of environmental influence - such as social interactions, structural complexity and physical exercise - on barrier composition, morphology and development, and considers the outcomes and implications of these interactions in the context of psychiatric disorders.</description><subject>Age</subject><subject>Blood vessels</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Blood-Brain Barrier - pathology</subject><subject>Brain - metabolism</subject><subject>Brain-Gut Axis</subject><subject>Cognition</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Communication</subject><subject>Corticosteroids</subject><subject>Cytokines</subject><subject>Developmental stages</subject><subject>Disease</subject><subject>Environmental aspects</subject><subject>Environmental conditions</subject><subject>Environmental information</subject><subject>Exercise</subject><subject>Gene-Environment Interaction</subject><subject>Genomes</subject><subject>Glucocorticoids</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Immune system</subject><subject>Intestinal microflora</subject><subject>Laboratories</subject><subject>Life span</subject><subject>Longevity</subject><subject>Mental disorders</subject><subject>Mental illness</subject><subject>Metabolites</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Morphology</subject><subject>Pathogenesis</subject><subject>Permeability</subject><subject>Proteins</subject><subject>Review Paper</subject><subject>Risk factors</subject><subject>Social aspects</subject><subject>Social behavior</subject><subject>Social interactions</subject><subject>Socioeconomic factors</subject><subject>Tumor necrosis 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China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of psychiatry & neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paton, Sam E J</au><au>Solano, José L</au><au>Coulombe-Rozon, François</au><au>Lebel, Manon</au><au>Menard, Caroline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Barrier-environment interactions along the gut-brain axis and their influence on cognition and behaviour throughout the lifespan</atitle><jtitle>Journal of psychiatry & neuroscience</jtitle><addtitle>J Psychiatry Neurosci</addtitle><date>2023-05</date><risdate>2023</risdate><volume>48</volume><issue>3</issue><spage>E190</spage><epage>E208</epage><pages>E190-E208</pages><issn>1180-4882</issn><issn>1488-2434</issn><eissn>1488-2434</eissn><abstract>Environment is known to substantially alter mental state and behaviour across the lifespan. Biological barriers such as the blood-brain barrier (BBB) and gut barrier (GB) are major hubs for communication of environmental information. Alterations in the structural, social and motor environment at different stages of life can influence function of the BBB and GB and their integrity to exert behavioural consequences. Importantly, each of these environmental components is associated with a distinct immune profile, glucocorticoid response and gut microbiome composition, creating unique effects on the BBB and GB. These barrier-environment interactions are sensitive to change throughout life, and positive or negative alterations at critical stages of development can exert long-lasting cognitive and behavioural consequences. Furthermore, because loss of barrier integrity is implicated in pathogenesis of mental disorders, the pathways of environmental influence represent important areas for understanding these diseases. Positive environments can be protective against stress- and age-related damage, raising the possibility of novel pharmacological targets. This review summarizes known mechanisms of environmental influence - such as social interactions, structural complexity and physical exercise - on barrier composition, morphology and development, and considers the outcomes and implications of these interactions in the context of psychiatric disorders.</abstract><cop>Canada</cop><pub>CMA Impact Inc</pub><pmid>37253482</pmid><doi>10.1503/jpn.220218</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of psychiatry & neuroscience, 2023-05, Vol.48 (3), p.E190-E208 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Age Blood vessels Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain - metabolism Brain-Gut Axis Cognition Cognition & reasoning Cognitive ability Communication Corticosteroids Cytokines Developmental stages Disease Environmental aspects Environmental conditions Environmental information Exercise Gene-Environment Interaction Genomes Glucocorticoids Homeostasis Humans Immune system Intestinal microflora Laboratories Life span Longevity Mental disorders Mental illness Metabolites Microbiomes Microbiota Microbiota (Symbiotic organisms) Morphology Pathogenesis Permeability Proteins Review Paper Risk factors Social aspects Social behavior Social interactions Socioeconomic factors Tumor necrosis factor-TNF |
| title | Barrier-environment interactions along the gut-brain axis and their influence on cognition and behaviour throughout the lifespan |
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