Silibinin, an HSP90 Inhibitor, on Human ACTH-Secreting Adenomas

Abstract Introduction: The glucocorticoid receptor is pivotal to control corticotrophin (ACTH) secretion, and its function is closely linked to the heat shock protein 90 (HSP90) chaperone complex. Impaired sensitivity to glucocorticoid feedback is a hallmark of human corticotroph adenomas, i.e., Cus...

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Veröffentlicht in:	Neuroendocrinology 2023-05, Vol.113 (6), p.606-614
Hauptverfasser:	Pecori Giraldi, Francesca, Cassarino, Maria Francesca, Sesta, Antonella, Lasio, Giovanni, Losa, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTH Cabergoline Dexamethasone Gene expression Heat shock proteins Medical research Medicine, Experimental Proteins Research Article
Online-Zugang:	Volltext
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