Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets

Aberrant biosynthesis and secretion of the insulin precursor proinsulin occurs in both type I and type II diabetes. Inflammatory cytokines are implicated in pancreatic islet stress and dysfunction in both forms of diabetes, but the mechanisms remain unclear. We sought to determine the effect of the...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2022-11, Vol.107 (11), p.3100-3110
Hauptverfasser:	Tran, Duc T, Pottekat, Anita, Lee, Kouta, Raghunathan, Megha, Loguercio, Salvatore, Mir, Saiful A, Paton, Adrienne W, Paton, James C, Arvan, Peter, Kaufman, Randal J, Itkin-Ansari, Pamela
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological response modifiers Clinical Cytokines - metabolism Dextrose Diabetes Mellitus, Type 2 - metabolism Enzyme-linked immunosorbent assay Ethylenediaminetetraacetic acid Genes Genetic transcription Genome-Wide Association Study Genomics Glucose Humans Immunoglobulin G Insulin - metabolism Insulin-Secreting Cells - metabolism Interferon Interleukin-6 - metabolism Interleukins Islets of Langerhans - metabolism Mass spectrometry Myosin Oxidases Physiological aspects Proinsulin - metabolism Protein binding Protein kinases RNA RNA sequencing Scientific equipment and supplies industry Surface active agents Type 2 diabetes
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