The autism spectrum among transgender youth: default mode functional connectivity
Abstract The common intersection of autism and transgender identities has been described in clinical and community contexts. This study investigates autism-related neurophenotypes among transgender youth. Forty-five transgender youth, evenly balanced across non-autistic, slightly subclinically autis...
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| Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2023-05, Vol.33 (11), p.6633-6647 |
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| container_title | Cerebral cortex (New York, N.Y. 1991) |
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| creator | Strang, John F McClellan, Lucy S Li, Sufang Jack, Allison E Wallace, Gregory L McQuaid, Goldie A Kenworthy, Lauren Anthony, Laura G Lai, Meng-Chuan Pelphrey, Kevin A Thalberg, Alexandra E Nelson, Eric E Phan, Jenny M Sadikova, Eleonora Fischbach, Abigail L Thomas, John Vaidya, Chandan J |
| description | Abstract
The common intersection of autism and transgender identities has been described in clinical and community contexts. This study investigates autism-related neurophenotypes among transgender youth. Forty-five transgender youth, evenly balanced across non-autistic, slightly subclinically autistic, and full-criteria autistic subgroupings, completed resting-state functional magnetic resonance imaging to examine functional connectivity. Results confirmed hypothesized default mode network (DMN) hub hyperconnectivity with visual and motor networks in autism, partially replicating previous studies comparing cisgender autistic and non-autistic adolescents. The slightly subclinically autistic group differed from both non-autistic and full-criteria autistic groups in DMN hub connectivity to ventral attention and sensorimotor networks, falling between non-autistic and full-criteria autistic groups. Autism traits showed a similar pattern to autism-related group analytics, and also related to hyperconnectivity between DMN hub and dorsal attention network. Internalizing, gender dysphoria, and gender minority-related stigma did not show connectivity differences. Connectivity differences within DMN followed previously reported patterns by designated sex at birth (i.e. female birth designation showing greater within-DMN connectivity). Overall, findings suggest behavioral diagnostics and autism traits in transgender youth correspond to observable differences in DMN hub connectivity. Further, this study reveals novel neurophenotypic characteristics associated with slightly subthreshold autism, highlighting the importance of research attention to this group. |
| doi_str_mv | 10.1093/cercor/bhac530 |
| format | Article |
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The common intersection of autism and transgender identities has been described in clinical and community contexts. This study investigates autism-related neurophenotypes among transgender youth. Forty-five transgender youth, evenly balanced across non-autistic, slightly subclinically autistic, and full-criteria autistic subgroupings, completed resting-state functional magnetic resonance imaging to examine functional connectivity. Results confirmed hypothesized default mode network (DMN) hub hyperconnectivity with visual and motor networks in autism, partially replicating previous studies comparing cisgender autistic and non-autistic adolescents. The slightly subclinically autistic group differed from both non-autistic and full-criteria autistic groups in DMN hub connectivity to ventral attention and sensorimotor networks, falling between non-autistic and full-criteria autistic groups. Autism traits showed a similar pattern to autism-related group analytics, and also related to hyperconnectivity between DMN hub and dorsal attention network. Internalizing, gender dysphoria, and gender minority-related stigma did not show connectivity differences. Connectivity differences within DMN followed previously reported patterns by designated sex at birth (i.e. female birth designation showing greater within-DMN connectivity). Overall, findings suggest behavioral diagnostics and autism traits in transgender youth correspond to observable differences in DMN hub connectivity. Further, this study reveals novel neurophenotypic characteristics associated with slightly subthreshold autism, highlighting the importance of research attention to this group.</description><identifier>ISSN: 1047-3211</identifier><identifier>ISSN: 1460-2199</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhac530</identifier><identifier>PMID: 36721890</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Adolescent ; Autism Spectrum Disorder - diagnostic imaging ; Autistic Disorder ; Brain - diagnostic imaging ; Brain Mapping - methods ; Child ; Female ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Neural Pathways - diagnostic imaging ; Original ; Transgender Persons ; Young Adult</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2023-05, Vol.33 (11), p.6633-6647</ispartof><rights>The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-c1af15626efe07bf9a0ff1e02078b3983fa6a4c2c07540bc7549d637410eb81e3</citedby><cites>FETCH-LOGICAL-c385t-c1af15626efe07bf9a0ff1e02078b3983fa6a4c2c07540bc7549d637410eb81e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36721890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strang, John F</creatorcontrib><creatorcontrib>McClellan, Lucy S</creatorcontrib><creatorcontrib>Li, Sufang</creatorcontrib><creatorcontrib>Jack, Allison E</creatorcontrib><creatorcontrib>Wallace, Gregory L</creatorcontrib><creatorcontrib>McQuaid, Goldie A</creatorcontrib><creatorcontrib>Kenworthy, Lauren</creatorcontrib><creatorcontrib>Anthony, Laura G</creatorcontrib><creatorcontrib>Lai, Meng-Chuan</creatorcontrib><creatorcontrib>Pelphrey, Kevin A</creatorcontrib><creatorcontrib>Thalberg, Alexandra E</creatorcontrib><creatorcontrib>Nelson, Eric E</creatorcontrib><creatorcontrib>Phan, Jenny M</creatorcontrib><creatorcontrib>Sadikova, Eleonora</creatorcontrib><creatorcontrib>Fischbach, Abigail L</creatorcontrib><creatorcontrib>Thomas, John</creatorcontrib><creatorcontrib>Vaidya, Chandan J</creatorcontrib><title>The autism spectrum among transgender youth: default mode functional connectivity</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Abstract
The common intersection of autism and transgender identities has been described in clinical and community contexts. This study investigates autism-related neurophenotypes among transgender youth. Forty-five transgender youth, evenly balanced across non-autistic, slightly subclinically autistic, and full-criteria autistic subgroupings, completed resting-state functional magnetic resonance imaging to examine functional connectivity. Results confirmed hypothesized default mode network (DMN) hub hyperconnectivity with visual and motor networks in autism, partially replicating previous studies comparing cisgender autistic and non-autistic adolescents. The slightly subclinically autistic group differed from both non-autistic and full-criteria autistic groups in DMN hub connectivity to ventral attention and sensorimotor networks, falling between non-autistic and full-criteria autistic groups. Autism traits showed a similar pattern to autism-related group analytics, and also related to hyperconnectivity between DMN hub and dorsal attention network. Internalizing, gender dysphoria, and gender minority-related stigma did not show connectivity differences. Connectivity differences within DMN followed previously reported patterns by designated sex at birth (i.e. female birth designation showing greater within-DMN connectivity). Overall, findings suggest behavioral diagnostics and autism traits in transgender youth correspond to observable differences in DMN hub connectivity. Further, this study reveals novel neurophenotypic characteristics associated with slightly subthreshold autism, highlighting the importance of research attention to this group.</description><subject>Adolescent</subject><subject>Autism Spectrum Disorder - diagnostic imaging</subject><subject>Autistic Disorder</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Mapping - methods</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Neural Pathways - diagnostic imaging</subject><subject>Original</subject><subject>Transgender Persons</subject><subject>Young Adult</subject><issn>1047-3211</issn><issn>1460-2199</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhq0K1JbClSPykR7SzthJnHBBqCoFqRJCKmfLcca7QYm9-KPS_nuCdqnoicvMSPPMO6N5GXuLcIXQy2tL0YZ4PWyNbSScsHOsW6gE9v2LtYZaVVIgnrFXKf0EQCUaccrOZKsEdj2cs-8PW-Km5CktPO3I5lgWbpbgNzxH49OG_EiR70PJ2w98JGfKnPkSRuKueJun4M3MbfB-nZ0ep7x_zV46Myd6c8wX7Mfn24ebL9X9t7uvN5_uKyu7JlcWjcOmFS05AjW43oBzSCBAdYPsO-lMa2orLKimhsGusR9bqWoEGjokecE-HnR3ZVhotOTXg2e9i9Ni4l4HM-nnHT9t9SY8agQhpQRcFd4fFWL4VShlvUzJ0jwbT6EkLZTCVnZCwYpeHVAbQ0qR3NMeBP3HCH0wQh-NWAfe_XvdE_738ytweQBC2f1P7DeoWpb4</recordid><startdate>20230524</startdate><enddate>20230524</enddate><creator>Strang, John F</creator><creator>McClellan, Lucy S</creator><creator>Li, Sufang</creator><creator>Jack, Allison E</creator><creator>Wallace, Gregory L</creator><creator>McQuaid, Goldie A</creator><creator>Kenworthy, Lauren</creator><creator>Anthony, Laura G</creator><creator>Lai, Meng-Chuan</creator><creator>Pelphrey, Kevin A</creator><creator>Thalberg, Alexandra E</creator><creator>Nelson, Eric E</creator><creator>Phan, Jenny M</creator><creator>Sadikova, Eleonora</creator><creator>Fischbach, Abigail L</creator><creator>Thomas, John</creator><creator>Vaidya, Chandan J</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230524</creationdate><title>The autism spectrum among transgender youth: default mode functional connectivity</title><author>Strang, John F ; McClellan, Lucy S ; Li, Sufang ; Jack, Allison E ; Wallace, Gregory L ; McQuaid, Goldie A ; Kenworthy, Lauren ; Anthony, Laura G ; Lai, Meng-Chuan ; Pelphrey, Kevin A ; Thalberg, Alexandra E ; Nelson, Eric E ; Phan, Jenny M ; Sadikova, Eleonora ; Fischbach, Abigail L ; Thomas, John ; Vaidya, Chandan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-c1af15626efe07bf9a0ff1e02078b3983fa6a4c2c07540bc7549d637410eb81e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adolescent</topic><topic>Autism Spectrum Disorder - diagnostic imaging</topic><topic>Autistic Disorder</topic><topic>Brain - diagnostic imaging</topic><topic>Brain Mapping - methods</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Neural Pathways - diagnostic imaging</topic><topic>Original</topic><topic>Transgender Persons</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strang, John F</creatorcontrib><creatorcontrib>McClellan, Lucy S</creatorcontrib><creatorcontrib>Li, Sufang</creatorcontrib><creatorcontrib>Jack, Allison E</creatorcontrib><creatorcontrib>Wallace, Gregory L</creatorcontrib><creatorcontrib>McQuaid, Goldie A</creatorcontrib><creatorcontrib>Kenworthy, Lauren</creatorcontrib><creatorcontrib>Anthony, Laura G</creatorcontrib><creatorcontrib>Lai, Meng-Chuan</creatorcontrib><creatorcontrib>Pelphrey, Kevin A</creatorcontrib><creatorcontrib>Thalberg, Alexandra E</creatorcontrib><creatorcontrib>Nelson, Eric E</creatorcontrib><creatorcontrib>Phan, Jenny M</creatorcontrib><creatorcontrib>Sadikova, Eleonora</creatorcontrib><creatorcontrib>Fischbach, Abigail L</creatorcontrib><creatorcontrib>Thomas, John</creatorcontrib><creatorcontrib>Vaidya, Chandan J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strang, John F</au><au>McClellan, Lucy S</au><au>Li, Sufang</au><au>Jack, Allison E</au><au>Wallace, Gregory L</au><au>McQuaid, Goldie A</au><au>Kenworthy, Lauren</au><au>Anthony, Laura G</au><au>Lai, Meng-Chuan</au><au>Pelphrey, Kevin A</au><au>Thalberg, Alexandra E</au><au>Nelson, Eric E</au><au>Phan, Jenny M</au><au>Sadikova, Eleonora</au><au>Fischbach, Abigail L</au><au>Thomas, John</au><au>Vaidya, Chandan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The autism spectrum among transgender youth: default mode functional connectivity</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2023-05-24</date><risdate>2023</risdate><volume>33</volume><issue>11</issue><spage>6633</spage><epage>6647</epage><pages>6633-6647</pages><issn>1047-3211</issn><issn>1460-2199</issn><eissn>1460-2199</eissn><abstract>Abstract
The common intersection of autism and transgender identities has been described in clinical and community contexts. This study investigates autism-related neurophenotypes among transgender youth. Forty-five transgender youth, evenly balanced across non-autistic, slightly subclinically autistic, and full-criteria autistic subgroupings, completed resting-state functional magnetic resonance imaging to examine functional connectivity. Results confirmed hypothesized default mode network (DMN) hub hyperconnectivity with visual and motor networks in autism, partially replicating previous studies comparing cisgender autistic and non-autistic adolescents. The slightly subclinically autistic group differed from both non-autistic and full-criteria autistic groups in DMN hub connectivity to ventral attention and sensorimotor networks, falling between non-autistic and full-criteria autistic groups. Autism traits showed a similar pattern to autism-related group analytics, and also related to hyperconnectivity between DMN hub and dorsal attention network. Internalizing, gender dysphoria, and gender minority-related stigma did not show connectivity differences. Connectivity differences within DMN followed previously reported patterns by designated sex at birth (i.e. female birth designation showing greater within-DMN connectivity). Overall, findings suggest behavioral diagnostics and autism traits in transgender youth correspond to observable differences in DMN hub connectivity. Further, this study reveals novel neurophenotypic characteristics associated with slightly subthreshold autism, highlighting the importance of research attention to this group.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>36721890</pmid><doi>10.1093/cercor/bhac530</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adolescent Autism Spectrum Disorder - diagnostic imaging Autistic Disorder Brain - diagnostic imaging Brain Mapping - methods Child Female Humans Magnetic Resonance Imaging - methods Male Neural Pathways - diagnostic imaging Original Transgender Persons Young Adult |
| title | The autism spectrum among transgender youth: default mode functional connectivity |
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