Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study
Background To investigate the aetiology of acute undifferentiated fever (AUF) among children under the age of five in Vietnam. Methods This prospective study was conducted in the Thai Binh paediatric hospital, between July 2020 and July 2021 among children with AUF at admission. Real-time PCR testin...
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| Veröffentlicht in: | Journal of Epidemiology and Global Health 2023-06, Vol.13 (2), p.163-172 |
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| creator | Tran, Xuan Duong Hoang, Van Thuan Dang, Thi Thuy Duong Vu, Thi Phuong To, Minh Manh Tran, Trong Kiem Do, Manh Dung Nguyen, Duy Cuong Nguyen, Quoc Tien Colson, Philippe Parola, Philippe Marty, Pierre Gautret, Philippe |
| description | Background
To investigate the aetiology of acute undifferentiated fever (AUF) among children under the age of five in Vietnam.
Methods
This prospective study was conducted in the Thai Binh paediatric hospital, between July 2020 and July 2021 among children with AUF at admission. Real-time PCR testing 18 microbial pathogens were done on blood samples.
Results
286 children were included, with median age of 16 months. 64.7% were male. 53.9% were positive for at least one pathogen by PCR. Enterovirus, human herpesvirus 6, adenovirus, and varicella zoster virus PCR were positive for 31.1, 12.6, 1.4, and 1.0% patients, respectively. Other pathogens tested negative by PCR. During the hospital stay, based on clinical criteria 47.2% children secondarily presented with signs of respiratory tract infections, 18.9% had hand, foot and mouth disease, 4.6% had chickenpox. 4.2% presented signs of central nervous system infections, 1.0% had dengue (antigenic test) and 1.0% had signs of gastrointestinal infection. Finally, 23.1% patients presented a fever with or without a rash and no other symptoms and ultimately received a diagnosis of AUF.
Conclusion
Real-time PCR of blood is useful for detecting pathogens and diagnosing infectious causes of AUF. Further prospective studies with blood and urine culture testing and PCR investigation of not only blood but also cerebrospinal fluid, throat, and skin samples according to symptoms would be of interest to confirm the predominance of viral infections in children with AUF and to guide therapeutic options. |
| doi_str_mv | 10.1007/s44197-023-00121-4 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_doaj_</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10231849</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_98f0d284c768403786ecf8ceca9404d1</doaj_id><sourcerecordid>37258852</sourcerecordid><originalsourceid>FETCH-LOGICAL-c547t-f3ca4e169d8d642564092a7c9214ec0452ee10c6dc549b92b74373375bb984973</originalsourceid><addsrcrecordid>eNp9kU9r3DAQxU1paEKaL9BD0bUHt5I8tqxeilm6TWChhfy5ClkaexW81iJrF_bbV47bkPTQk8TMe78Z5mXZB0Y_M0rFlwmASZFTXuSUMs5yeJNdcM5oXlEGb1_8z7OraXItBZCyBFq8y84Lwcu6LvlFNjYYnR98fyK-I405RCT3o3VdhwHH6HRES9Z4xECanR97stq6wabWrErFuEXS9Dib1-6IxI3kwWEc9e4raciv4Kc9mjh3buPBnt5nZ50eJrz6815m9-vvd6vrfPPzx82q2eSmBBHzrjAakFXS1rYCXlZAJdfCSM4ADYWSIzJqKpvkspW8FVCIohBl28oapCgus5uFa71-VPvgdjqclNdOPRV86JUO0ZkBlaw7ankNRlR1uo6oKzRdbdBoCRQsS6xvC2t_aHdoTTpL0MMr6OvO6Laq90fFUjgsrZMInxbC9h_fdbNRc40CY2m6OM7T-KI16XZTwO7ZwKiak1dL8irB1VPyCpLp48sVny1_c06CYhFMqTX2GNSjP4QxRfA_7G8vILf1</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Tran, Xuan Duong ; Hoang, Van Thuan ; Dang, Thi Thuy Duong ; Vu, Thi Phuong ; To, Minh Manh ; Tran, Trong Kiem ; Do, Manh Dung ; Nguyen, Duy Cuong ; Nguyen, Quoc Tien ; Colson, Philippe ; Parola, Philippe ; Marty, Pierre ; Gautret, Philippe</creator><creatorcontrib>Tran, Xuan Duong ; Hoang, Van Thuan ; Dang, Thi Thuy Duong ; Vu, Thi Phuong ; To, Minh Manh ; Tran, Trong Kiem ; Do, Manh Dung ; Nguyen, Duy Cuong ; Nguyen, Quoc Tien ; Colson, Philippe ; Parola, Philippe ; Marty, Pierre ; Gautret, Philippe</creatorcontrib><description>Background
To investigate the aetiology of acute undifferentiated fever (AUF) among children under the age of five in Vietnam.
Methods
This prospective study was conducted in the Thai Binh paediatric hospital, between July 2020 and July 2021 among children with AUF at admission. Real-time PCR testing 18 microbial pathogens were done on blood samples.
Results
286 children were included, with median age of 16 months. 64.7% were male. 53.9% were positive for at least one pathogen by PCR. Enterovirus, human herpesvirus 6, adenovirus, and varicella zoster virus PCR were positive for 31.1, 12.6, 1.4, and 1.0% patients, respectively. Other pathogens tested negative by PCR. During the hospital stay, based on clinical criteria 47.2% children secondarily presented with signs of respiratory tract infections, 18.9% had hand, foot and mouth disease, 4.6% had chickenpox. 4.2% presented signs of central nervous system infections, 1.0% had dengue (antigenic test) and 1.0% had signs of gastrointestinal infection. Finally, 23.1% patients presented a fever with or without a rash and no other symptoms and ultimately received a diagnosis of AUF.
Conclusion
Real-time PCR of blood is useful for detecting pathogens and diagnosing infectious causes of AUF. Further prospective studies with blood and urine culture testing and PCR investigation of not only blood but also cerebrospinal fluid, throat, and skin samples according to symptoms would be of interest to confirm the predominance of viral infections in children with AUF and to guide therapeutic options.</description><identifier>ISSN: 2210-6014</identifier><identifier>ISSN: 2210-6006</identifier><identifier>EISSN: 2210-6014</identifier><identifier>DOI: 10.1007/s44197-023-00121-4</identifier><identifier>PMID: 37258852</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Bacteriology ; Cardiology and cardiovascular system ; Child ; Children ; Emerging diseases ; Enterovirus ; Enterovirus Infections - cerebrospinal fluid ; Female ; Fever without a source ; Hospitalization ; Human health and pathology ; Humans ; Infant ; Infectious diseases ; Length of Stay ; Life Sciences ; Male ; Medicine ; Medicine & Public Health ; Microbiology and Parasitology ; Parasitology ; Prospective Studies ; Rash ; Research Article ; Vietnam - epidemiology ; Virology</subject><ispartof>Journal of Epidemiology and Global Health, 2023-06, Vol.13 (2), p.163-172</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-f3ca4e169d8d642564092a7c9214ec0452ee10c6dc549b92b74373375bb984973</citedby><cites>FETCH-LOGICAL-c547t-f3ca4e169d8d642564092a7c9214ec0452ee10c6dc549b92b74373375bb984973</cites><orcidid>0000-0002-4126-9167 ; 0000-0002-1664-958X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231849/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231849/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37258852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-04116847$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Tran, Xuan Duong</creatorcontrib><creatorcontrib>Hoang, Van Thuan</creatorcontrib><creatorcontrib>Dang, Thi Thuy Duong</creatorcontrib><creatorcontrib>Vu, Thi Phuong</creatorcontrib><creatorcontrib>To, Minh Manh</creatorcontrib><creatorcontrib>Tran, Trong Kiem</creatorcontrib><creatorcontrib>Do, Manh Dung</creatorcontrib><creatorcontrib>Nguyen, Duy Cuong</creatorcontrib><creatorcontrib>Nguyen, Quoc Tien</creatorcontrib><creatorcontrib>Colson, Philippe</creatorcontrib><creatorcontrib>Parola, Philippe</creatorcontrib><creatorcontrib>Marty, Pierre</creatorcontrib><creatorcontrib>Gautret, Philippe</creatorcontrib><title>Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study</title><title>Journal of Epidemiology and Global Health</title><addtitle>J Epidemiol Glob Health</addtitle><addtitle>J Epidemiol Glob Health</addtitle><description>Background
To investigate the aetiology of acute undifferentiated fever (AUF) among children under the age of five in Vietnam.
Methods
This prospective study was conducted in the Thai Binh paediatric hospital, between July 2020 and July 2021 among children with AUF at admission. Real-time PCR testing 18 microbial pathogens were done on blood samples.
Results
286 children were included, with median age of 16 months. 64.7% were male. 53.9% were positive for at least one pathogen by PCR. Enterovirus, human herpesvirus 6, adenovirus, and varicella zoster virus PCR were positive for 31.1, 12.6, 1.4, and 1.0% patients, respectively. Other pathogens tested negative by PCR. During the hospital stay, based on clinical criteria 47.2% children secondarily presented with signs of respiratory tract infections, 18.9% had hand, foot and mouth disease, 4.6% had chickenpox. 4.2% presented signs of central nervous system infections, 1.0% had dengue (antigenic test) and 1.0% had signs of gastrointestinal infection. Finally, 23.1% patients presented a fever with or without a rash and no other symptoms and ultimately received a diagnosis of AUF.
Conclusion
Real-time PCR of blood is useful for detecting pathogens and diagnosing infectious causes of AUF. Further prospective studies with blood and urine culture testing and PCR investigation of not only blood but also cerebrospinal fluid, throat, and skin samples according to symptoms would be of interest to confirm the predominance of viral infections in children with AUF and to guide therapeutic options.</description><subject>Bacteriology</subject><subject>Cardiology and cardiovascular system</subject><subject>Child</subject><subject>Children</subject><subject>Emerging diseases</subject><subject>Enterovirus</subject><subject>Enterovirus Infections - cerebrospinal fluid</subject><subject>Female</subject><subject>Fever without a source</subject><subject>Hospitalization</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Length of Stay</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbiology and Parasitology</subject><subject>Parasitology</subject><subject>Prospective Studies</subject><subject>Rash</subject><subject>Research Article</subject><subject>Vietnam - epidemiology</subject><subject>Virology</subject><issn>2210-6014</issn><issn>2210-6006</issn><issn>2210-6014</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU9r3DAQxU1paEKaL9BD0bUHt5I8tqxeilm6TWChhfy5ClkaexW81iJrF_bbV47bkPTQk8TMe78Z5mXZB0Y_M0rFlwmASZFTXuSUMs5yeJNdcM5oXlEGb1_8z7OraXItBZCyBFq8y84Lwcu6LvlFNjYYnR98fyK-I405RCT3o3VdhwHH6HRES9Z4xECanR97stq6wabWrErFuEXS9Dib1-6IxI3kwWEc9e4raciv4Kc9mjh3buPBnt5nZ50eJrz6815m9-vvd6vrfPPzx82q2eSmBBHzrjAakFXS1rYCXlZAJdfCSM4ADYWSIzJqKpvkspW8FVCIohBl28oapCgus5uFa71-VPvgdjqclNdOPRV86JUO0ZkBlaw7ankNRlR1uo6oKzRdbdBoCRQsS6xvC2t_aHdoTTpL0MMr6OvO6Laq90fFUjgsrZMInxbC9h_fdbNRc40CY2m6OM7T-KI16XZTwO7ZwKiak1dL8irB1VPyCpLp48sVny1_c06CYhFMqTX2GNSjP4QxRfA_7G8vILf1</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Tran, Xuan Duong</creator><creator>Hoang, Van Thuan</creator><creator>Dang, Thi Thuy Duong</creator><creator>Vu, Thi Phuong</creator><creator>To, Minh Manh</creator><creator>Tran, Trong Kiem</creator><creator>Do, Manh Dung</creator><creator>Nguyen, Duy Cuong</creator><creator>Nguyen, Quoc Tien</creator><creator>Colson, Philippe</creator><creator>Parola, Philippe</creator><creator>Marty, Pierre</creator><creator>Gautret, Philippe</creator><general>Springer Netherlands</general><general>Springer</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4126-9167</orcidid><orcidid>https://orcid.org/0000-0002-1664-958X</orcidid></search><sort><creationdate>20230601</creationdate><title>Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study</title><author>Tran, Xuan Duong ; Hoang, Van Thuan ; Dang, Thi Thuy Duong ; Vu, Thi Phuong ; To, Minh Manh ; Tran, Trong Kiem ; Do, Manh Dung ; Nguyen, Duy Cuong ; Nguyen, Quoc Tien ; Colson, Philippe ; Parola, Philippe ; Marty, Pierre ; Gautret, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-f3ca4e169d8d642564092a7c9214ec0452ee10c6dc549b92b74373375bb984973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bacteriology</topic><topic>Cardiology and cardiovascular system</topic><topic>Child</topic><topic>Children</topic><topic>Emerging diseases</topic><topic>Enterovirus</topic><topic>Enterovirus Infections - cerebrospinal fluid</topic><topic>Female</topic><topic>Fever without a source</topic><topic>Hospitalization</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Length of Stay</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microbiology and Parasitology</topic><topic>Parasitology</topic><topic>Prospective Studies</topic><topic>Rash</topic><topic>Research Article</topic><topic>Vietnam - epidemiology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tran, Xuan Duong</creatorcontrib><creatorcontrib>Hoang, Van Thuan</creatorcontrib><creatorcontrib>Dang, Thi Thuy Duong</creatorcontrib><creatorcontrib>Vu, Thi Phuong</creatorcontrib><creatorcontrib>To, Minh Manh</creatorcontrib><creatorcontrib>Tran, Trong Kiem</creatorcontrib><creatorcontrib>Do, Manh Dung</creatorcontrib><creatorcontrib>Nguyen, Duy Cuong</creatorcontrib><creatorcontrib>Nguyen, Quoc Tien</creatorcontrib><creatorcontrib>Colson, Philippe</creatorcontrib><creatorcontrib>Parola, Philippe</creatorcontrib><creatorcontrib>Marty, Pierre</creatorcontrib><creatorcontrib>Gautret, Philippe</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Epidemiology and Global Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, Xuan Duong</au><au>Hoang, Van Thuan</au><au>Dang, Thi Thuy Duong</au><au>Vu, Thi Phuong</au><au>To, Minh Manh</au><au>Tran, Trong Kiem</au><au>Do, Manh Dung</au><au>Nguyen, Duy Cuong</au><au>Nguyen, Quoc Tien</au><au>Colson, Philippe</au><au>Parola, Philippe</au><au>Marty, Pierre</au><au>Gautret, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study</atitle><jtitle>Journal of Epidemiology and Global Health</jtitle><stitle>J Epidemiol Glob Health</stitle><addtitle>J Epidemiol Glob Health</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>13</volume><issue>2</issue><spage>163</spage><epage>172</epage><pages>163-172</pages><issn>2210-6014</issn><issn>2210-6006</issn><eissn>2210-6014</eissn><abstract>Background
To investigate the aetiology of acute undifferentiated fever (AUF) among children under the age of five in Vietnam.
Methods
This prospective study was conducted in the Thai Binh paediatric hospital, between July 2020 and July 2021 among children with AUF at admission. Real-time PCR testing 18 microbial pathogens were done on blood samples.
Results
286 children were included, with median age of 16 months. 64.7% were male. 53.9% were positive for at least one pathogen by PCR. Enterovirus, human herpesvirus 6, adenovirus, and varicella zoster virus PCR were positive for 31.1, 12.6, 1.4, and 1.0% patients, respectively. Other pathogens tested negative by PCR. During the hospital stay, based on clinical criteria 47.2% children secondarily presented with signs of respiratory tract infections, 18.9% had hand, foot and mouth disease, 4.6% had chickenpox. 4.2% presented signs of central nervous system infections, 1.0% had dengue (antigenic test) and 1.0% had signs of gastrointestinal infection. Finally, 23.1% patients presented a fever with or without a rash and no other symptoms and ultimately received a diagnosis of AUF.
Conclusion
Real-time PCR of blood is useful for detecting pathogens and diagnosing infectious causes of AUF. Further prospective studies with blood and urine culture testing and PCR investigation of not only blood but also cerebrospinal fluid, throat, and skin samples according to symptoms would be of interest to confirm the predominance of viral infections in children with AUF and to guide therapeutic options.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>37258852</pmid><doi>10.1007/s44197-023-00121-4</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4126-9167</orcidid><orcidid>https://orcid.org/0000-0002-1664-958X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Bacteriology Cardiology and cardiovascular system Child Children Emerging diseases Enterovirus Enterovirus Infections - cerebrospinal fluid Female Fever without a source Hospitalization Human health and pathology Humans Infant Infectious diseases Length of Stay Life Sciences Male Medicine Medicine & Public Health Microbiology and Parasitology Parasitology Prospective Studies Rash Research Article Vietnam - epidemiology Virology |
| title | Aetiology of Acute Undifferentiated Fever Among Children Under the Age of Five in Vietnam: A Prospective Study |
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