The DNA Damage Sensor MRE11 Regulates Efficient Replication of the Autonomous Parvovirus Minute Virus of Mice

Parvoviruses are single-stranded DNA viruses that utilize host proteins to vigorously replicate in the nuclei of host cells, leading to cell cycle arrest. The autonomous parvovirus, minute virus of mice (MVM), forms viral replication centers in the nucleus which are adjacent to cellular DNA damage r...

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Veröffentlicht in:	Journal of virology 2023-05, Vol.97 (5), p.e0046123-e0046123
Hauptverfasser:	Bunke, Lauren E, Larsen, Clairine I S, Pita-Aquino, Jessica N, Jones, Isabella K, Majumder, Kinjal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - metabolism Discoidin Domain Receptors - genetics Discoidin Domain Receptors - metabolism DNA Damage DNA Replication Genome and Regulation of Viral Gene Expression Genome Replication and Regulation of Viral Gene Expression Mice Minute Virus of Mice - genetics MRE11 Homologue Protein - metabolism Parvoviridae Infections - genetics Virology Virus Replication - physiology
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