Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease
Congenital heart disease (CHD) is a common birth defect in the United States. CHD infants are more likely to have smaller head circumference and neurodevelopmental delays; however, the cause is unknown. Altered cerebrovascular hemodynamics may contribute to neurologic abnormalities, such as smaller...
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| Veröffentlicht in: | Pediatric cardiology 2022-10, Vol.43 (7), p.1624-1630 |
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| creator | Tran, Nhu N. Tran, Michelle Panigrahy, Ashok Brady, Ken M. Votava-Smith, Jodie K. |
| description | Congenital heart disease (CHD) is a common birth defect in the United States. CHD infants are more likely to have smaller head circumference and neurodevelopmental delays; however, the cause is unknown. Altered cerebrovascular hemodynamics may contribute to neurologic abnormalities, such as smaller head circumference, thus we created a novel Cerebrovascular Stability Index (CSI), as a surrogate for cerebral autoregulation. We hypothesized that CHD infants would have an association between CSI and head circumference. We performed a prospective, longitudinal study in CHD infants and healthy controls. We measured CSI and head circumference at 4 time points (newborn, 3, 6, 9 months). We calculated CSI by subtracting the average 2-min sitting from supine cerebral oxygenation (rcSO
2
) over three consecutive tilts (0–90°), then averaged the change score for each age. Linear regressions quantified the relationship between CSI and head circumference. We performed 177 assessments in total (80 healthy controls, 97 CHD infants). The average head circumference was smaller in CHD infants (39.2 cm) compared to healthy controls (41.6 cm) (
p
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| doi_str_mv | 10.1007/s00246-022-02891-3 |
| format | Article |
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2
) over three consecutive tilts (0–90°), then averaged the change score for each age. Linear regressions quantified the relationship between CSI and head circumference. We performed 177 assessments in total (80 healthy controls, 97 CHD infants). The average head circumference was smaller in CHD infants (39.2 cm) compared to healthy controls (41.6 cm) (
p
< 0.001) and head circumference increased by 0.27 cm as CSI improved in the sample (
p
= 0.04) overall when combining all time points. Similarly, head circumference increased by 0.32 cm as CSI improved among CHD infants (
p
= 0.04). We found CSI significantly associated with head circumference in our sample overall and CHD infants alone, which suggests that impaired CSI may affect brain size in CHD infants. Future studies are needed to better understand the mechanism of interaction between CSI and brain growth.</description><identifier>ISSN: 0172-0643</identifier><identifier>EISSN: 1432-1971</identifier><identifier>DOI: 10.1007/s00246-022-02891-3</identifier><identifier>PMID: 35426499</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cardiac Surgery ; Cardiology ; Head ; Heart Defects, Congenital - complications ; Hemodynamics ; Humans ; Infant ; Infant, Newborn ; Longitudinal Studies ; Medicine ; Medicine & Public Health ; Original Article ; Prospective Studies ; Vascular Surgery</subject><ispartof>Pediatric cardiology, 2022-10, Vol.43 (7), p.1624-1630</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-17bba73c3ca3516ac596b02e64bc501e0b01086868af1361ba884664ac815a563</citedby><cites>FETCH-LOGICAL-c447t-17bba73c3ca3516ac596b02e64bc501e0b01086868af1361ba884664ac815a563</cites><orcidid>0000-0003-4350-4893 ; 0000-0002-3429-6415 ; 0000-0002-8934-5333 ; 0000-0003-1966-6681</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00246-022-02891-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00246-022-02891-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35426499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tran, Nhu N.</creatorcontrib><creatorcontrib>Tran, Michelle</creatorcontrib><creatorcontrib>Panigrahy, Ashok</creatorcontrib><creatorcontrib>Brady, Ken M.</creatorcontrib><creatorcontrib>Votava-Smith, Jodie K.</creatorcontrib><title>Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease</title><title>Pediatric cardiology</title><addtitle>Pediatr Cardiol</addtitle><addtitle>Pediatr Cardiol</addtitle><description>Congenital heart disease (CHD) is a common birth defect in the United States. CHD infants are more likely to have smaller head circumference and neurodevelopmental delays; however, the cause is unknown. Altered cerebrovascular hemodynamics may contribute to neurologic abnormalities, such as smaller head circumference, thus we created a novel Cerebrovascular Stability Index (CSI), as a surrogate for cerebral autoregulation. We hypothesized that CHD infants would have an association between CSI and head circumference. We performed a prospective, longitudinal study in CHD infants and healthy controls. We measured CSI and head circumference at 4 time points (newborn, 3, 6, 9 months). We calculated CSI by subtracting the average 2-min sitting from supine cerebral oxygenation (rcSO
2
) over three consecutive tilts (0–90°), then averaged the change score for each age. Linear regressions quantified the relationship between CSI and head circumference. We performed 177 assessments in total (80 healthy controls, 97 CHD infants). The average head circumference was smaller in CHD infants (39.2 cm) compared to healthy controls (41.6 cm) (
p
< 0.001) and head circumference increased by 0.27 cm as CSI improved in the sample (
p
= 0.04) overall when combining all time points. Similarly, head circumference increased by 0.32 cm as CSI improved among CHD infants (
p
= 0.04). We found CSI significantly associated with head circumference in our sample overall and CHD infants alone, which suggests that impaired CSI may affect brain size in CHD infants. Future studies are needed to better understand the mechanism of interaction between CSI and brain growth.</description><subject>Cardiac Surgery</subject><subject>Cardiology</subject><subject>Head</subject><subject>Heart Defects, Congenital - complications</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Longitudinal Studies</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Prospective Studies</subject><subject>Vascular Surgery</subject><issn>0172-0643</issn><issn>1432-1971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EokvhC3BAPnIJjP_ESU6oLJRWqsQBEEdr4p20rrJ2sZ1CT_3qeLulgguyLFt6v3kzmsfYSwFvBED3NgNIbRqQst5-EI16xFZCK9mIoROP2QpEVyWj1QF7lvMlAPTQt0_ZgWq1NHoYVuz2KOfoPBYfA48TX1OiMcVrzG6ZMfEvBUc_-3LDT8OGfnEMG35CuOFrn9yynSoeHPH3VH4ShQpNGErm3325uGN3n7gUvo7hnIIvOO_KU-EffCbM9Jw9mXDO9OL-PWTfjj9-XZ80Z58_na6PzhqndVca0Y0jdsoph6oVBl07mBEkGT26FgTBCAJ6Uw9OQhkxYt9rYzS6XrTYGnXI3u19r5ZxSxtHoSSc7VXyW0w3NqK3_yrBX9jzeG0FSAVGqOrw-t4hxR8L5WK3PjuaZwwUl2ylqYMNSkldUblHXYo5J5oe-giwu-jsPjpbo7N30dmd_6u_J3wo-ZNVBdQeyFWq20z2Mi4p1K39z_Y3AX6mYQ</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Tran, Nhu N.</creator><creator>Tran, Michelle</creator><creator>Panigrahy, Ashok</creator><creator>Brady, Ken M.</creator><creator>Votava-Smith, Jodie K.</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4350-4893</orcidid><orcidid>https://orcid.org/0000-0002-3429-6415</orcidid><orcidid>https://orcid.org/0000-0002-8934-5333</orcidid><orcidid>https://orcid.org/0000-0003-1966-6681</orcidid></search><sort><creationdate>20221001</creationdate><title>Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease</title><author>Tran, Nhu N. ; Tran, Michelle ; Panigrahy, Ashok ; Brady, Ken M. ; Votava-Smith, Jodie K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-17bba73c3ca3516ac596b02e64bc501e0b01086868af1361ba884664ac815a563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiac Surgery</topic><topic>Cardiology</topic><topic>Head</topic><topic>Heart Defects, Congenital - complications</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Longitudinal Studies</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Prospective Studies</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tran, Nhu N.</creatorcontrib><creatorcontrib>Tran, Michelle</creatorcontrib><creatorcontrib>Panigrahy, Ashok</creatorcontrib><creatorcontrib>Brady, Ken M.</creatorcontrib><creatorcontrib>Votava-Smith, Jodie K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, Nhu N.</au><au>Tran, Michelle</au><au>Panigrahy, Ashok</au><au>Brady, Ken M.</au><au>Votava-Smith, Jodie K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease</atitle><jtitle>Pediatric cardiology</jtitle><stitle>Pediatr Cardiol</stitle><addtitle>Pediatr Cardiol</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>43</volume><issue>7</issue><spage>1624</spage><epage>1630</epage><pages>1624-1630</pages><issn>0172-0643</issn><eissn>1432-1971</eissn><abstract>Congenital heart disease (CHD) is a common birth defect in the United States. CHD infants are more likely to have smaller head circumference and neurodevelopmental delays; however, the cause is unknown. Altered cerebrovascular hemodynamics may contribute to neurologic abnormalities, such as smaller head circumference, thus we created a novel Cerebrovascular Stability Index (CSI), as a surrogate for cerebral autoregulation. We hypothesized that CHD infants would have an association between CSI and head circumference. We performed a prospective, longitudinal study in CHD infants and healthy controls. We measured CSI and head circumference at 4 time points (newborn, 3, 6, 9 months). We calculated CSI by subtracting the average 2-min sitting from supine cerebral oxygenation (rcSO
2
) over three consecutive tilts (0–90°), then averaged the change score for each age. Linear regressions quantified the relationship between CSI and head circumference. We performed 177 assessments in total (80 healthy controls, 97 CHD infants). The average head circumference was smaller in CHD infants (39.2 cm) compared to healthy controls (41.6 cm) (
p
< 0.001) and head circumference increased by 0.27 cm as CSI improved in the sample (
p
= 0.04) overall when combining all time points. Similarly, head circumference increased by 0.32 cm as CSI improved among CHD infants (
p
= 0.04). We found CSI significantly associated with head circumference in our sample overall and CHD infants alone, which suggests that impaired CSI may affect brain size in CHD infants. Future studies are needed to better understand the mechanism of interaction between CSI and brain growth.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35426499</pmid><doi>10.1007/s00246-022-02891-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-4350-4893</orcidid><orcidid>https://orcid.org/0000-0002-3429-6415</orcidid><orcidid>https://orcid.org/0000-0002-8934-5333</orcidid><orcidid>https://orcid.org/0000-0003-1966-6681</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiac Surgery Cardiology Head Heart Defects, Congenital - complications Hemodynamics Humans Infant Infant, Newborn Longitudinal Studies Medicine Medicine & Public Health Original Article Prospective Studies Vascular Surgery |
| title | Association of Cerebrovascular Stability Index and Head Circumference Between Infants With and Without Congenital Heart Disease |
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