A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery
Background The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor sur...
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| Veröffentlicht in: | Acta neurochirurgica 2023-06, Vol.165 (6), p.1645-1653 |
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| container_title | Acta neurochirurgica |
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| creator | de Sain, A.M. Mantione, M.H.M. Wajer, I.M.C. Huenges van Zandvoort, M.J.E. Willems, P.W.A. Robe, P.A. Ruis, C. |
| description | Background
The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor surgery in patients with suspected gliomas, by comparing preoperative, early postoperative, and late postoperative functioning. A more detailed timeline will be helpful in informing candidates for surgery about what to expect regarding their cognitive functioning.
Methods
Thirty-seven patients were included in this study. Cognitive functioning was measured by means of a broad cognitive screener preoperatively, days after surgery and months after surgery in patients who underwent awake brain tumor surgery with cognitive monitoring. The cognitive screener included tests for object naming, reading, attention span, working memory, inhibition, inhibition/switching, and visuoperception. We performed a Friedman ANOVA to analyze on group level.
Results
Overall, no significant differences were found between preoperative cognitive functioning, early postoperative cognitive functioning, and late postoperative cognitive functioning, except for performances on the inhibition task. Directly after surgery, patients were significantly slower on this task. However, in the following months after surgery, they returned to their preoperative level.
Conclusion
The timeline of cognitive functioning after awake tumor surgery appeared overall stable in the early and late postoperative phase, except for inhibition, which is more difficult in the first days after awake brain tumor surgery. This more detailed timeline of cognitive functioning, in combination with future research, can possibly be contributing in informing patients and caregivers what to expect after awake brain tumor surgery. |
| doi_str_mv | 10.1007/s00701-023-05588-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10227103</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2806072553</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-90d40c720017d737fa84bd6e17d2773ade7a6ad214f31c4cae6009552d04620d3</originalsourceid><addsrcrecordid>eNp9kU1PFTEUhhujkQ_9Ay5MEzZuBk-_pnNXhBAFEhI3ujNpetvOUJxpL-0MhH_vgYsILtyctjlP376nLyEfGBwyAP25YgHWABcNKNV1jXpFdmEleYMFXj_b75C9Wq8AGNdSvCU7QsNKCy13yc9jOscpjDEFmnvq8pDiHG8C7Zfk5phTTAONiQ5jzJOlGzvHkOZKby8zXZIPZcjU3tpfga6LRW5eplxoXcoQyt078qa3Yw3vH9d98uPrl-8nZ83Ft9Pzk-OLxkmt5mYFXoLTHP1pj7Z628m1bwOeuNbC-qBtaz1nshfMSWdDC7BSinuQLQcv9snRVnezrKfgHTosdjSbEidb7ky20bzspHhphnxjGHCuGQhU-PSoUPL1EupsplhdGEebQl6q4R20oLlS9-jBP-hVXkrC-ZDiwNAY65DiW8qVXGsJ_ZMbBuY-PbNNz2B65iE9o_DSx-dzPF35ExcCYgtUbCX84r9v_0f2N8qBpgE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2820195518</pqid></control><display><type>article</type><title>A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>de Sain, A.M. ; Mantione, M.H.M. ; Wajer, I.M.C. Huenges ; van Zandvoort, M.J.E. ; Willems, P.W.A. ; Robe, P.A. ; Ruis, C.</creator><creatorcontrib>de Sain, A.M. ; Mantione, M.H.M. ; Wajer, I.M.C. Huenges ; van Zandvoort, M.J.E. ; Willems, P.W.A. ; Robe, P.A. ; Ruis, C.</creatorcontrib><description>Background
The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor surgery in patients with suspected gliomas, by comparing preoperative, early postoperative, and late postoperative functioning. A more detailed timeline will be helpful in informing candidates for surgery about what to expect regarding their cognitive functioning.
Methods
Thirty-seven patients were included in this study. Cognitive functioning was measured by means of a broad cognitive screener preoperatively, days after surgery and months after surgery in patients who underwent awake brain tumor surgery with cognitive monitoring. The cognitive screener included tests for object naming, reading, attention span, working memory, inhibition, inhibition/switching, and visuoperception. We performed a Friedman ANOVA to analyze on group level.
Results
Overall, no significant differences were found between preoperative cognitive functioning, early postoperative cognitive functioning, and late postoperative cognitive functioning, except for performances on the inhibition task. Directly after surgery, patients were significantly slower on this task. However, in the following months after surgery, they returned to their preoperative level.
Conclusion
The timeline of cognitive functioning after awake tumor surgery appeared overall stable in the early and late postoperative phase, except for inhibition, which is more difficult in the first days after awake brain tumor surgery. This more detailed timeline of cognitive functioning, in combination with future research, can possibly be contributing in informing patients and caregivers what to expect after awake brain tumor surgery.</description><identifier>ISSN: 0942-0940</identifier><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-023-05588-5</identifier><identifier>PMID: 37097374</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Brain cancer ; Brain Neoplasms - pathology ; Brain tumors ; Cognition ; Cognitive ability ; Craniotomy ; Glioma ; Glioma - complications ; Glioma - pathology ; Glioma - surgery ; Humans ; Interventional Radiology ; Medicine ; Medicine & Public Health ; Minimally Invasive Surgery ; Neurology ; Neuroradiology ; Neurosurgery ; Original ; Original Article ; Short term memory ; Surgery ; Surgical Orthopedics ; Wakefulness</subject><ispartof>Acta neurochirurgica, 2023-06, Vol.165 (6), p.1645-1653</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-90d40c720017d737fa84bd6e17d2773ade7a6ad214f31c4cae6009552d04620d3</citedby><cites>FETCH-LOGICAL-c475t-90d40c720017d737fa84bd6e17d2773ade7a6ad214f31c4cae6009552d04620d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00701-023-05588-5$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00701-023-05588-5$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37097374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Sain, A.M.</creatorcontrib><creatorcontrib>Mantione, M.H.M.</creatorcontrib><creatorcontrib>Wajer, I.M.C. Huenges</creatorcontrib><creatorcontrib>van Zandvoort, M.J.E.</creatorcontrib><creatorcontrib>Willems, P.W.A.</creatorcontrib><creatorcontrib>Robe, P.A.</creatorcontrib><creatorcontrib>Ruis, C.</creatorcontrib><title>A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir</addtitle><addtitle>Acta Neurochir (Wien)</addtitle><description>Background
The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor surgery in patients with suspected gliomas, by comparing preoperative, early postoperative, and late postoperative functioning. A more detailed timeline will be helpful in informing candidates for surgery about what to expect regarding their cognitive functioning.
Methods
Thirty-seven patients were included in this study. Cognitive functioning was measured by means of a broad cognitive screener preoperatively, days after surgery and months after surgery in patients who underwent awake brain tumor surgery with cognitive monitoring. The cognitive screener included tests for object naming, reading, attention span, working memory, inhibition, inhibition/switching, and visuoperception. We performed a Friedman ANOVA to analyze on group level.
Results
Overall, no significant differences were found between preoperative cognitive functioning, early postoperative cognitive functioning, and late postoperative cognitive functioning, except for performances on the inhibition task. Directly after surgery, patients were significantly slower on this task. However, in the following months after surgery, they returned to their preoperative level.
Conclusion
The timeline of cognitive functioning after awake tumor surgery appeared overall stable in the early and late postoperative phase, except for inhibition, which is more difficult in the first days after awake brain tumor surgery. This more detailed timeline of cognitive functioning, in combination with future research, can possibly be contributing in informing patients and caregivers what to expect after awake brain tumor surgery.</description><subject>Brain cancer</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain tumors</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Craniotomy</subject><subject>Glioma</subject><subject>Glioma - complications</subject><subject>Glioma - pathology</subject><subject>Glioma - surgery</subject><subject>Humans</subject><subject>Interventional Radiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minimally Invasive Surgery</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Original</subject><subject>Original Article</subject><subject>Short term memory</subject><subject>Surgery</subject><subject>Surgical Orthopedics</subject><subject>Wakefulness</subject><issn>0942-0940</issn><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kU1PFTEUhhujkQ_9Ay5MEzZuBk-_pnNXhBAFEhI3ujNpetvOUJxpL-0MhH_vgYsILtyctjlP376nLyEfGBwyAP25YgHWABcNKNV1jXpFdmEleYMFXj_b75C9Wq8AGNdSvCU7QsNKCy13yc9jOscpjDEFmnvq8pDiHG8C7Zfk5phTTAONiQ5jzJOlGzvHkOZKby8zXZIPZcjU3tpfga6LRW5eplxoXcoQyt078qa3Yw3vH9d98uPrl-8nZ83Ft9Pzk-OLxkmt5mYFXoLTHP1pj7Z628m1bwOeuNbC-qBtaz1nshfMSWdDC7BSinuQLQcv9snRVnezrKfgHTosdjSbEidb7ky20bzspHhphnxjGHCuGQhU-PSoUPL1EupsplhdGEebQl6q4R20oLlS9-jBP-hVXkrC-ZDiwNAY65DiW8qVXGsJ_ZMbBuY-PbNNz2B65iE9o_DSx-dzPF35ExcCYgtUbCX84r9v_0f2N8qBpgE</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>de Sain, A.M.</creator><creator>Mantione, M.H.M.</creator><creator>Wajer, I.M.C. Huenges</creator><creator>van Zandvoort, M.J.E.</creator><creator>Willems, P.W.A.</creator><creator>Robe, P.A.</creator><creator>Ruis, C.</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230601</creationdate><title>A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery</title><author>de Sain, A.M. ; Mantione, M.H.M. ; Wajer, I.M.C. Huenges ; van Zandvoort, M.J.E. ; Willems, P.W.A. ; Robe, P.A. ; Ruis, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-90d40c720017d737fa84bd6e17d2773ade7a6ad214f31c4cae6009552d04620d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Brain cancer</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain tumors</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Craniotomy</topic><topic>Glioma</topic><topic>Glioma - complications</topic><topic>Glioma - pathology</topic><topic>Glioma - surgery</topic><topic>Humans</topic><topic>Interventional Radiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Minimally Invasive Surgery</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Original</topic><topic>Original Article</topic><topic>Short term memory</topic><topic>Surgery</topic><topic>Surgical Orthopedics</topic><topic>Wakefulness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Sain, A.M.</creatorcontrib><creatorcontrib>Mantione, M.H.M.</creatorcontrib><creatorcontrib>Wajer, I.M.C. Huenges</creatorcontrib><creatorcontrib>van Zandvoort, M.J.E.</creatorcontrib><creatorcontrib>Willems, P.W.A.</creatorcontrib><creatorcontrib>Robe, P.A.</creatorcontrib><creatorcontrib>Ruis, C.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Sain, A.M.</au><au>Mantione, M.H.M.</au><au>Wajer, I.M.C. Huenges</au><au>van Zandvoort, M.J.E.</au><au>Willems, P.W.A.</au><au>Robe, P.A.</au><au>Ruis, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery</atitle><jtitle>Acta neurochirurgica</jtitle><stitle>Acta Neurochir</stitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>165</volume><issue>6</issue><spage>1645</spage><epage>1653</epage><pages>1645-1653</pages><issn>0942-0940</issn><issn>0001-6268</issn><eissn>0942-0940</eissn><abstract>Background
The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor surgery in patients with suspected gliomas, by comparing preoperative, early postoperative, and late postoperative functioning. A more detailed timeline will be helpful in informing candidates for surgery about what to expect regarding their cognitive functioning.
Methods
Thirty-seven patients were included in this study. Cognitive functioning was measured by means of a broad cognitive screener preoperatively, days after surgery and months after surgery in patients who underwent awake brain tumor surgery with cognitive monitoring. The cognitive screener included tests for object naming, reading, attention span, working memory, inhibition, inhibition/switching, and visuoperception. We performed a Friedman ANOVA to analyze on group level.
Results
Overall, no significant differences were found between preoperative cognitive functioning, early postoperative cognitive functioning, and late postoperative cognitive functioning, except for performances on the inhibition task. Directly after surgery, patients were significantly slower on this task. However, in the following months after surgery, they returned to their preoperative level.
Conclusion
The timeline of cognitive functioning after awake tumor surgery appeared overall stable in the early and late postoperative phase, except for inhibition, which is more difficult in the first days after awake brain tumor surgery. This more detailed timeline of cognitive functioning, in combination with future research, can possibly be contributing in informing patients and caregivers what to expect after awake brain tumor surgery.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>37097374</pmid><doi>10.1007/s00701-023-05588-5</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Brain cancer Brain Neoplasms - pathology Brain tumors Cognition Cognitive ability Craniotomy Glioma Glioma - complications Glioma - pathology Glioma - surgery Humans Interventional Radiology Medicine Medicine & Public Health Minimally Invasive Surgery Neurology Neuroradiology Neurosurgery Original Original Article Short term memory Surgery Surgical Orthopedics Wakefulness |
| title | A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery |
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