The Validity of Heart Rate Variability Obtained from Electrocardiography and Blood Pressure in Rats Subjected to Isoproterenol-Induced Heart Ischemia
Heart rate variability (HRV) is calculated by electrocardiography (ECG-HRV) or blood pressure (BP-HRV). The purpose of this study was to determine the validity of the above methods in rats with normal and ischemic hearts during the baroreflex maneuver. The study was conducted at Shiraz University of...
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| Veröffentlicht in: | Journal of Tehran University Heart Center 2023, Vol.18 (1), p.33-38 |
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| creator | Farokhipour, Maryam Ketabchi, Farzaneh |
| description | Heart rate variability (HRV) is calculated by electrocardiography (ECG-HRV) or blood pressure (BP-HRV). The purpose of this study was to determine the validity of the above methods in rats with normal and ischemic hearts during the baroreflex maneuver.
The study was conducted at Shiraz University of Medical Sciences, Shiraz, Iran, in 2021. Sprague-Dawley rats were divided into a sham group and an isoproterenol-mediated cardiac ischemia (ISO) group. Saline and isoproterenol (150 mg/kg) injected subcutaneously for 2 consecutive days in the sham and ISO groups, respectively. Then, the animals were anesthetized with an intraperitoneal injection of sodium thiopental (60 mg/kg), and the femoral artery and vein were cannulated. Baroreflex was activated using an intravenous injection of phenylephrine (10 μg/100 μL saline). ECG, BP, and heart rate (HR) were recorded, and the time domain of HRV and baroreflex gain were calculated.
Baroreflex gain in the ISO group (male, weight=275.8±2.8 g, n=8) was lower than that in the sham group (male, weight=258±2.3 g, n=8) (P |
| doi_str_mv | 10.18502/jthc.v18i1.12579 |
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The study was conducted at Shiraz University of Medical Sciences, Shiraz, Iran, in 2021. Sprague-Dawley rats were divided into a sham group and an isoproterenol-mediated cardiac ischemia (ISO) group. Saline and isoproterenol (150 mg/kg) injected subcutaneously for 2 consecutive days in the sham and ISO groups, respectively. Then, the animals were anesthetized with an intraperitoneal injection of sodium thiopental (60 mg/kg), and the femoral artery and vein were cannulated. Baroreflex was activated using an intravenous injection of phenylephrine (10 μg/100 μL saline). ECG, BP, and heart rate (HR) were recorded, and the time domain of HRV and baroreflex gain were calculated.
Baroreflex gain in the ISO group (male, weight=275.8±2.8 g, n=8) was lower than that in the sham group (male, weight=258±2.3 g, n=8) (P<0.05). ECG-HRV indicated an increase in the standard deviation of the RR interval (SDRR), the index of overall HRV, and the parasympathetic index of the root mean square of successive differences (RMSSD) in both groups. However, the rise in SDRR and RMSSD in the ISO group was less than that in the sham group (P<0.05). SDRR and RMSSD obtained from BP did not show a difference between the sham and ISO groups, nor did they correspond with the results seen in baroreflex gain.
BP-HRV was not as valuable as ECG-HRV in assessing cardiac ischemia.</description><identifier>ISSN: 1735-5370</identifier><identifier>ISSN: 1735-8620</identifier><identifier>EISSN: 2008-2371</identifier><identifier>DOI: 10.18502/jthc.v18i1.12579</identifier><identifier>PMID: 37252214</identifier><language>eng</language><publisher>Iran: Tehran University of Medical Sciences</publisher><subject>Baroreceptors ; Baroreflex ; Blood pressure ; EKG ; Electrocardiography ; Femoral artery ; Heart rate ; Injection ; Ischemia ; Isoproterenol ; Males ; Mathematical analysis ; Medical science ; Original ; Parasympathetic nervous system ; Phenylephrine ; Reflexes ; Thiopental ; Weight</subject><ispartof>Journal of Tehran University Heart Center, 2023, Vol.18 (1), p.33-38</ispartof><rights>Copyright © 2023 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.</rights><rights>2023. This work is published under https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225032/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10225032/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37252214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farokhipour, Maryam</creatorcontrib><creatorcontrib>Ketabchi, Farzaneh</creatorcontrib><title>The Validity of Heart Rate Variability Obtained from Electrocardiography and Blood Pressure in Rats Subjected to Isoproterenol-Induced Heart Ischemia</title><title>Journal of Tehran University Heart Center</title><addtitle>J Tehran Heart Cent</addtitle><description>Heart rate variability (HRV) is calculated by electrocardiography (ECG-HRV) or blood pressure (BP-HRV). The purpose of this study was to determine the validity of the above methods in rats with normal and ischemic hearts during the baroreflex maneuver.
The study was conducted at Shiraz University of Medical Sciences, Shiraz, Iran, in 2021. Sprague-Dawley rats were divided into a sham group and an isoproterenol-mediated cardiac ischemia (ISO) group. Saline and isoproterenol (150 mg/kg) injected subcutaneously for 2 consecutive days in the sham and ISO groups, respectively. Then, the animals were anesthetized with an intraperitoneal injection of sodium thiopental (60 mg/kg), and the femoral artery and vein were cannulated. Baroreflex was activated using an intravenous injection of phenylephrine (10 μg/100 μL saline). ECG, BP, and heart rate (HR) were recorded, and the time domain of HRV and baroreflex gain were calculated.
Baroreflex gain in the ISO group (male, weight=275.8±2.8 g, n=8) was lower than that in the sham group (male, weight=258±2.3 g, n=8) (P<0.05). ECG-HRV indicated an increase in the standard deviation of the RR interval (SDRR), the index of overall HRV, and the parasympathetic index of the root mean square of successive differences (RMSSD) in both groups. However, the rise in SDRR and RMSSD in the ISO group was less than that in the sham group (P<0.05). SDRR and RMSSD obtained from BP did not show a difference between the sham and ISO groups, nor did they correspond with the results seen in baroreflex gain.
BP-HRV was not as valuable as ECG-HRV in assessing cardiac ischemia.</description><subject>Baroreceptors</subject><subject>Baroreflex</subject><subject>Blood pressure</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Femoral artery</subject><subject>Heart rate</subject><subject>Injection</subject><subject>Ischemia</subject><subject>Isoproterenol</subject><subject>Males</subject><subject>Mathematical analysis</subject><subject>Medical science</subject><subject>Original</subject><subject>Parasympathetic nervous system</subject><subject>Phenylephrine</subject><subject>Reflexes</subject><subject>Thiopental</subject><subject>Weight</subject><issn>1735-5370</issn><issn>1735-8620</issn><issn>2008-2371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNpdks1uEzEUhUcIREPhAdggS2zYTPC_PSsEVaEjVSqCwtby2HcSR5NxsGcq5UF4X5ykVJSVpXvO-Xxtnap6TfCSaIHp-820dss7ogNZEipU86RaUIx1TZkiT6sFUUzUgil8Vr3IeYOxJJSL59UZU1RQSvii-n27BvTTDsGHaY9ij67Apgl9s9NhnILtwnBQbrrJhhE86lPcossB3JSis8mHuEp2t94jO3r0aYjRo68Jcp4ToDAeQBl9n7tNCZT0FFGb4y7FCRKMcajb0c-uCKdr2-zWsA32ZfWst0OGV_fnefXj8-XtxVV9ffOlvfh4XTsmSVMzrGzXSedIh70WnDAA4awVspFcAqW9ahjXvhPCeewwdYT0krkeEyWbTrLzqj1xfbQbs0tha9PeRBvMcRDTypS1ghvA2MbhBrji0HPeU66JUkpI3mspey1EYX04sXZztwXvYJySHR5BHytjWJtVvDMEUyowo4Xw7p6Q4q8Z8mS2ITsYBjtCnLOhmuJGNo3Qxfr2P-smzmksf1VcHGvFSx2Ki5xcLsWcE_QP2xBsjg0yhwaZY4PMsUEl8-bfZzwk_laG_QGNEcSN</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Farokhipour, Maryam</creator><creator>Ketabchi, Farzaneh</creator><general>Tehran University of Medical Sciences</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>2023</creationdate><title>The Validity of Heart Rate Variability Obtained from Electrocardiography and Blood Pressure in Rats Subjected to Isoproterenol-Induced Heart Ischemia</title><author>Farokhipour, Maryam ; Ketabchi, Farzaneh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3619-307abb6cc1b0d85413ee5caa569646e22f79348db55cd0c02c11f63cf01769b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Baroreceptors</topic><topic>Baroreflex</topic><topic>Blood pressure</topic><topic>EKG</topic><topic>Electrocardiography</topic><topic>Femoral artery</topic><topic>Heart rate</topic><topic>Injection</topic><topic>Ischemia</topic><topic>Isoproterenol</topic><topic>Males</topic><topic>Mathematical analysis</topic><topic>Medical science</topic><topic>Original</topic><topic>Parasympathetic nervous system</topic><topic>Phenylephrine</topic><topic>Reflexes</topic><topic>Thiopental</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farokhipour, Maryam</creatorcontrib><creatorcontrib>Ketabchi, Farzaneh</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Tehran University Heart Center</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farokhipour, Maryam</au><au>Ketabchi, Farzaneh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Validity of Heart Rate Variability Obtained from Electrocardiography and Blood Pressure in Rats Subjected to Isoproterenol-Induced Heart Ischemia</atitle><jtitle>Journal of Tehran University Heart Center</jtitle><addtitle>J Tehran Heart Cent</addtitle><date>2023</date><risdate>2023</risdate><volume>18</volume><issue>1</issue><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>1735-5370</issn><issn>1735-8620</issn><eissn>2008-2371</eissn><abstract>Heart rate variability (HRV) is calculated by electrocardiography (ECG-HRV) or blood pressure (BP-HRV). The purpose of this study was to determine the validity of the above methods in rats with normal and ischemic hearts during the baroreflex maneuver.
The study was conducted at Shiraz University of Medical Sciences, Shiraz, Iran, in 2021. Sprague-Dawley rats were divided into a sham group and an isoproterenol-mediated cardiac ischemia (ISO) group. Saline and isoproterenol (150 mg/kg) injected subcutaneously for 2 consecutive days in the sham and ISO groups, respectively. Then, the animals were anesthetized with an intraperitoneal injection of sodium thiopental (60 mg/kg), and the femoral artery and vein were cannulated. Baroreflex was activated using an intravenous injection of phenylephrine (10 μg/100 μL saline). ECG, BP, and heart rate (HR) were recorded, and the time domain of HRV and baroreflex gain were calculated.
Baroreflex gain in the ISO group (male, weight=275.8±2.8 g, n=8) was lower than that in the sham group (male, weight=258±2.3 g, n=8) (P<0.05). ECG-HRV indicated an increase in the standard deviation of the RR interval (SDRR), the index of overall HRV, and the parasympathetic index of the root mean square of successive differences (RMSSD) in both groups. However, the rise in SDRR and RMSSD in the ISO group was less than that in the sham group (P<0.05). SDRR and RMSSD obtained from BP did not show a difference between the sham and ISO groups, nor did they correspond with the results seen in baroreflex gain.
BP-HRV was not as valuable as ECG-HRV in assessing cardiac ischemia.</abstract><cop>Iran</cop><pub>Tehran University of Medical Sciences</pub><pmid>37252214</pmid><doi>10.18502/jthc.v18i1.12579</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Baroreceptors Baroreflex Blood pressure EKG Electrocardiography Femoral artery Heart rate Injection Ischemia Isoproterenol Males Mathematical analysis Medical science Original Parasympathetic nervous system Phenylephrine Reflexes Thiopental Weight |
| title | The Validity of Heart Rate Variability Obtained from Electrocardiography and Blood Pressure in Rats Subjected to Isoproterenol-Induced Heart Ischemia |
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