Effect of Curcumin Consumption on Inflammation and Oxidative Stress in Patients on Hemodialysis: A Literature Review
Advanced chronic kidney disease (CKD) stages lead to exacerbated inflammation and oxidative stress. Patients with CKD in stage 5 need renal hemodialysis (HD) to remove toxins and waste products. However, this renal replacement therapy is inefficient in controlling inflammation. Regular curcumin cons...
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| Veröffentlicht in: | Nutrients 2023-05, Vol.15 (10), p.2239 |
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| creator | D'andurain, Javiera López, Vanessa Arazo-Rusindo, Migdalia Tiscornia, Caterina Aicardi, Valeria Simón, Layla Mariotti-Celis, María Salomé |
| description | Advanced chronic kidney disease (CKD) stages lead to exacerbated inflammation and oxidative stress. Patients with CKD in stage 5 need renal hemodialysis (HD) to remove toxins and waste products. However, this renal replacement therapy is inefficient in controlling inflammation. Regular curcumin consumption has been shown to reduce inflammation and oxidative stress in subjects with chronic pathologies, suggesting that the daily intake of curcumin may alleviate these conditions in HD patients. This review analyzes the available scientific evidence regarding the effect of curcumin intake on oxidative stress and inflammation in HD patients, focusing on the mechanisms and consequences of HD and curcumin consumption. The inclusion of curcumin as a dietary therapeutic supplement in HD patients has shown to control the inflammation status. However, the optimal dose and oral vehicle for curcumin administration are yet to be determined. It is important to consider studies on curcumin bioaccessibility to design effective oral administration vehicles. This information will contribute to the achievement of future nutritional interventions that validate the efficacy of curcumin supplementation as part of diet therapy in HD. |
| doi_str_mv | 10.3390/nu15102239 |
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Patients with CKD in stage 5 need renal hemodialysis (HD) to remove toxins and waste products. However, this renal replacement therapy is inefficient in controlling inflammation. Regular curcumin consumption has been shown to reduce inflammation and oxidative stress in subjects with chronic pathologies, suggesting that the daily intake of curcumin may alleviate these conditions in HD patients. This review analyzes the available scientific evidence regarding the effect of curcumin intake on oxidative stress and inflammation in HD patients, focusing on the mechanisms and consequences of HD and curcumin consumption. The inclusion of curcumin as a dietary therapeutic supplement in HD patients has shown to control the inflammation status. However, the optimal dose and oral vehicle for curcumin administration are yet to be determined. It is important to consider studies on curcumin bioaccessibility to design effective oral administration vehicles. This information will contribute to the achievement of future nutritional interventions that validate the efficacy of curcumin supplementation as part of diet therapy in HD.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15102239</identifier><identifier>PMID: 37242121</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antioxidants ; Bioavailability ; Body fat ; Chronic kidney failure ; Consumption ; Curcumin ; Curcumin - pharmacology ; Curcumin - therapeutic use ; Cytokines ; Developing countries ; Diabetes ; Dialysate ; Diet ; Hemodialysis ; Hormones ; Humans ; Hypertension ; Inflammation ; Inflammation - drug therapy ; Kidney diseases ; Kidney transplants ; LDCs ; Literature reviews ; Metabolism ; Oral administration ; Oxidation ; Oxidative Stress ; Pathology ; Peritoneal dialysis ; Proteins ; Renal Dialysis - adverse effects ; Renal Insufficiency, Chronic - drug therapy ; Review ; Toxins ; Tumor necrosis factor-TNF</subject><ispartof>Nutrients, 2023-05, Vol.15 (10), p.2239</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Patients with CKD in stage 5 need renal hemodialysis (HD) to remove toxins and waste products. However, this renal replacement therapy is inefficient in controlling inflammation. Regular curcumin consumption has been shown to reduce inflammation and oxidative stress in subjects with chronic pathologies, suggesting that the daily intake of curcumin may alleviate these conditions in HD patients. This review analyzes the available scientific evidence regarding the effect of curcumin intake on oxidative stress and inflammation in HD patients, focusing on the mechanisms and consequences of HD and curcumin consumption. The inclusion of curcumin as a dietary therapeutic supplement in HD patients has shown to control the inflammation status. However, the optimal dose and oral vehicle for curcumin administration are yet to be determined. It is important to consider studies on curcumin bioaccessibility to design effective oral administration vehicles. 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| subjects | Antioxidants Bioavailability Body fat Chronic kidney failure Consumption Curcumin Curcumin - pharmacology Curcumin - therapeutic use Cytokines Developing countries Diabetes Dialysate Diet Hemodialysis Hormones Humans Hypertension Inflammation Inflammation - drug therapy Kidney diseases Kidney transplants LDCs Literature reviews Metabolism Oral administration Oxidation Oxidative Stress Pathology Peritoneal dialysis Proteins Renal Dialysis - adverse effects Renal Insufficiency, Chronic - drug therapy Review Toxins Tumor necrosis factor-TNF |
| title | Effect of Curcumin Consumption on Inflammation and Oxidative Stress in Patients on Hemodialysis: A Literature Review |
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