Obesity Is Associated with Changes in Laboratory Biomarkers in Chilean Patients Hospitalized with COVID-19
It is reported that patients with obesity are more frequently hospitalized for COVID-19, and evidence exists that obesity is a risk factor, regardless of other comorbidities. The objective of this study was to evaluate the association of obesity with changes in laboratory biomarkers in hospitalized...
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| Veröffentlicht in: | Journal of clinical medicine 2023-05, Vol.12 (10), p.3392 |
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| creator | Viscardi, Sharon Marileo, Luis Delgado, Hugo San Martín, Andrés Hernández, Loreto Garcés, Paola Guzmán-Oyarzo, Dina Boguen, Rodrigo Medina, Gustavo Letelier, Pablo Villano, Ines Guzmán, Neftalí |
| description | It is reported that patients with obesity are more frequently hospitalized for COVID-19, and evidence exists that obesity is a risk factor, regardless of other comorbidities. The objective of this study was to evaluate the association of obesity with changes in laboratory biomarkers in hospitalized Chilean patients.
A total of 202 hospitalized patients (71 with obesity and 131 without obesity) with a diagnosis of COVID-19 were included in the study. Demographic, clinical, and laboratory (days 1, 3, 7, 15) data were obtained. We performed a statistical analysis, assuming significance with a value of
< 0.05.
Significant differences in chronic respiratory pathology are observed between patients with and without obesity. The inflammatory markers CPR, ferritin, NLR, and PLR are elevated during the evaluated period, while changes in leukocyte populations are present on day 1 (eosinophils) and day 3 (lymphocytes). Finally, a persistent elevation of D-dimer level is observed, presenting significant differences on day 7 between patients with and without obesity. Obesity had a positive correlation with admission to the critical patient unit, invasive mechanical ventilation, and length of hospital stay.
Patients with obesity hospitalized for COVID-19 present marked elevations of inflammatory and hemostasis parameters, with a correlation between obesity, changes in laboratory biomarkers, and the risk of adverse clinical outcomes also observed. |
| doi_str_mv | 10.3390/jcm12103392 |
| format | Article |
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A total of 202 hospitalized patients (71 with obesity and 131 without obesity) with a diagnosis of COVID-19 were included in the study. Demographic, clinical, and laboratory (days 1, 3, 7, 15) data were obtained. We performed a statistical analysis, assuming significance with a value of
< 0.05.
Significant differences in chronic respiratory pathology are observed between patients with and without obesity. The inflammatory markers CPR, ferritin, NLR, and PLR are elevated during the evaluated period, while changes in leukocyte populations are present on day 1 (eosinophils) and day 3 (lymphocytes). Finally, a persistent elevation of D-dimer level is observed, presenting significant differences on day 7 between patients with and without obesity. Obesity had a positive correlation with admission to the critical patient unit, invasive mechanical ventilation, and length of hospital stay.
Patients with obesity hospitalized for COVID-19 present marked elevations of inflammatory and hemostasis parameters, with a correlation between obesity, changes in laboratory biomarkers, and the risk of adverse clinical outcomes also observed.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12103392</identifier><identifier>PMID: 37240496</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Biological markers ; Biomarkers ; Blood ; Clinical medicine ; Complications and side effects ; Coronaviruses ; COVID-19 ; Hospital patients ; Lymphocytes ; Medical examination ; Medical research ; Medicine, Experimental ; Obesity ; Prognosis</subject><ispartof>Journal of clinical medicine, 2023-05, Vol.12 (10), p.3392</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c435t-8df8a1c644885b9b046a0921f1ba5abecb0660b184283750b08daa145fd5f1043</cites><orcidid>0000-0002-4785-8464 ; 0000-0003-4872-9821 ; 0000-0002-1755-358X ; 0000-0001-5806-9164</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219576/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219576/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37240496$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Viscardi, Sharon</creatorcontrib><creatorcontrib>Marileo, Luis</creatorcontrib><creatorcontrib>Delgado, Hugo</creatorcontrib><creatorcontrib>San Martín, Andrés</creatorcontrib><creatorcontrib>Hernández, Loreto</creatorcontrib><creatorcontrib>Garcés, Paola</creatorcontrib><creatorcontrib>Guzmán-Oyarzo, Dina</creatorcontrib><creatorcontrib>Boguen, Rodrigo</creatorcontrib><creatorcontrib>Medina, Gustavo</creatorcontrib><creatorcontrib>Letelier, Pablo</creatorcontrib><creatorcontrib>Villano, Ines</creatorcontrib><creatorcontrib>Guzmán, Neftalí</creatorcontrib><title>Obesity Is Associated with Changes in Laboratory Biomarkers in Chilean Patients Hospitalized with COVID-19</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>It is reported that patients with obesity are more frequently hospitalized for COVID-19, and evidence exists that obesity is a risk factor, regardless of other comorbidities. The objective of this study was to evaluate the association of obesity with changes in laboratory biomarkers in hospitalized Chilean patients.
A total of 202 hospitalized patients (71 with obesity and 131 without obesity) with a diagnosis of COVID-19 were included in the study. Demographic, clinical, and laboratory (days 1, 3, 7, 15) data were obtained. We performed a statistical analysis, assuming significance with a value of
< 0.05.
Significant differences in chronic respiratory pathology are observed between patients with and without obesity. The inflammatory markers CPR, ferritin, NLR, and PLR are elevated during the evaluated period, while changes in leukocyte populations are present on day 1 (eosinophils) and day 3 (lymphocytes). Finally, a persistent elevation of D-dimer level is observed, presenting significant differences on day 7 between patients with and without obesity. Obesity had a positive correlation with admission to the critical patient unit, invasive mechanical ventilation, and length of hospital stay.
Patients with obesity hospitalized for COVID-19 present marked elevations of inflammatory and hemostasis parameters, with a correlation between obesity, changes in laboratory biomarkers, and the risk of adverse clinical outcomes also observed.</description><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Clinical medicine</subject><subject>Complications and side effects</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Hospital patients</subject><subject>Lymphocytes</subject><subject>Medical examination</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Obesity</subject><subject>Prognosis</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkk1vEzEQhlcIRKu2J-7IEhcktO34Y3e9JxRSaCNFCgfgao293sRhdx3sDSj99Ti0DSnCc_BI88w7H5ose0XhkvMartamp4xC8tmz7JRBVeXAJX9-5J9kFzGuIT0pBaPVy-yEV0yAqMvTbL3QNrpxR2aRTGL0xuFoG_LLjSsyXeGwtJG4gcxR-4CjDzvywfkew3cb_gSmK9dZHMhnHJ0dxkhufdy4ETt3d5BZfJtd57Q-z1602EV78fCfZV8_ffwyvc3ni5vZdDLPjeDFmMumlUhNKYSUha41iBKhZrSlGgvU1mgoS9A0zSJ5VYAG2SBSUbRN0VIQ_Cx7f6-72ereNia1FbBTm-BS3zvl0amnkcGt1NL_VBQYrYuqTApvHxSC_7G1cVS9i8Z2HQ7Wb6NikgEwwWqe0Df_oGu_DUOaL1G0FgVQKv9SS-ysckPrU2GzF1WTqmBlKkr3ZS__QyVrbO-MH2ybdv004d19ggk-xmDbw5AU1P481NF5JPr18V4O7OMx8N-VOrMt</recordid><startdate>20230510</startdate><enddate>20230510</enddate><creator>Viscardi, Sharon</creator><creator>Marileo, Luis</creator><creator>Delgado, Hugo</creator><creator>San Martín, Andrés</creator><creator>Hernández, Loreto</creator><creator>Garcés, Paola</creator><creator>Guzmán-Oyarzo, Dina</creator><creator>Boguen, Rodrigo</creator><creator>Medina, Gustavo</creator><creator>Letelier, Pablo</creator><creator>Villano, Ines</creator><creator>Guzmán, Neftalí</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4785-8464</orcidid><orcidid>https://orcid.org/0000-0003-4872-9821</orcidid><orcidid>https://orcid.org/0000-0002-1755-358X</orcidid><orcidid>https://orcid.org/0000-0001-5806-9164</orcidid></search><sort><creationdate>20230510</creationdate><title>Obesity Is Associated with Changes in Laboratory Biomarkers in Chilean Patients Hospitalized with COVID-19</title><author>Viscardi, Sharon ; 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The objective of this study was to evaluate the association of obesity with changes in laboratory biomarkers in hospitalized Chilean patients.
A total of 202 hospitalized patients (71 with obesity and 131 without obesity) with a diagnosis of COVID-19 were included in the study. Demographic, clinical, and laboratory (days 1, 3, 7, 15) data were obtained. We performed a statistical analysis, assuming significance with a value of
< 0.05.
Significant differences in chronic respiratory pathology are observed between patients with and without obesity. The inflammatory markers CPR, ferritin, NLR, and PLR are elevated during the evaluated period, while changes in leukocyte populations are present on day 1 (eosinophils) and day 3 (lymphocytes). Finally, a persistent elevation of D-dimer level is observed, presenting significant differences on day 7 between patients with and without obesity. Obesity had a positive correlation with admission to the critical patient unit, invasive mechanical ventilation, and length of hospital stay.
Patients with obesity hospitalized for COVID-19 present marked elevations of inflammatory and hemostasis parameters, with a correlation between obesity, changes in laboratory biomarkers, and the risk of adverse clinical outcomes also observed.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37240496</pmid><doi>10.3390/jcm12103392</doi><orcidid>https://orcid.org/0000-0002-4785-8464</orcidid><orcidid>https://orcid.org/0000-0003-4872-9821</orcidid><orcidid>https://orcid.org/0000-0002-1755-358X</orcidid><orcidid>https://orcid.org/0000-0001-5806-9164</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Biological markers Biomarkers Blood Clinical medicine Complications and side effects Coronaviruses COVID-19 Hospital patients Lymphocytes Medical examination Medical research Medicine, Experimental Obesity Prognosis |
| title | Obesity Is Associated with Changes in Laboratory Biomarkers in Chilean Patients Hospitalized with COVID-19 |
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