Toxic Determination of Cry11 Mutated Proteins Obtained Using Rational Design and Its Computational Analysis

Cry11 proteins are toxic to , the vector of dengue, chikungunya, and Zika viruses. Cry11Aa and Cry11Bb are protoxins, which when activated present their active-toxin form in two fragments between 30 and 35 kDa respectively. Previous studies conducted with Cry11Aa and Cry11Bb genes using DNA shufflin...

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Veröffentlicht in:	International journal of molecular sciences 2023-05, Vol.24 (10), p.9079
Hauptverfasser:	Suárez-Barrera, Miguel O, Herrera-Pineda, Diego F, Rondón-Villarreal, Paola, Pinzón-Reyes, Efraín Hernando, Ochoa, Rodrigo, Visser, Lydia, Rueda-Forero, Nohora Juliana
Format:	Artikel
Sprache:	eng
Schlagworte:	Aedes - genetics Aedes - metabolism Amino acids Analysis Animals Bacillus thuringiensis - genetics Bacillus thuringiensis - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Proteins - toxicity Cancer Cell viability Colorectal carcinoma Cytotoxicity Disease control DNA shuffling Endotoxins - genetics Endotoxins - metabolism Endotoxins - toxicity Hemolysin Proteins - genetics Hemolysin Proteins - metabolism Insects Larva - genetics Larva - metabolism Molecular dynamics Mosquito Vectors Mutagenesis Mutants Mutation Phenylalanine Protein structure Proteins Site-directed mutagenesis Tertiary structure Toxicity Toxins Tryptophan Tumor cell lines Vector-borne diseases Vectors (Biology) Zika Virus - metabolism Zika Virus Infection
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