Clinical Profiling and Biomarkers for Post-Operative Atrial Fibrillation Prediction in Patients Undergoing Cardiac Surgery
Post-operative atrial fibrillation (POAF) is the most common arrhythmia in the post-operative period after cardiac surgery. We aim to investigate the main clinical, local, and/or peripheral biochemical and molecular predictors for POAF in patients undergoing coronary and/or valve surgery. Between Au...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical medicine 2023-05, Vol.12 (10), p.3565 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 3565 |
| container_title | Journal of clinical medicine |
| container_volume | 12 |
| creator | Iglesias-Álvarez, Diego Fu, Xiaoran Martínez-Cereijo, José Manuel Agra-Bermejo, Rosa María Veiras-Del Río, Sonia Selas-Cobos, Salomé Rial-Munin, María Victoria Eiras-Mariño, María Martínez-Salgado, Adrián Taboada-Muñiz, Manuel Reija-López, Laura Souaf, Souhayla García-Carro, Javier Fernández-González, Ángel Luis Adrio-Nazar, Belén González-Juanatey, José Ramón Eiras, Sonia Rodríguez-Mañero, Moisés |
| description | Post-operative atrial fibrillation (POAF) is the most common arrhythmia in the post-operative period after cardiac surgery. We aim to investigate the main clinical, local, and/or peripheral biochemical and molecular predictors for POAF in patients undergoing coronary and/or valve surgery. Between August 2020 and September 2022, consecutive patients undergoing cardiac surgery without previous history of AF were studied. Clinical variables, plasma, and biological tissues (epicardial and subcutaneous fat) were obtained before surgery. Pre-operative markers associated with inflammation, adiposity, atrial stretch, and fibrosis were analyzed on peripheral and local samples with multiplex assay and real-time PCR. Univariate and multivariate logistic regression analyses were performed in order to identify the main predictors for POAF. Patients were followed-up until hospital discharge. Out of 123 consecutive patients without prior AF, 43 (34.9%) developed POAF during hospitalization. The main predictors were cardiopulmonary bypass time (odds ratio (OR) 1.008 (95% confidence interval (CI), 1.002-1.013),
= 0.005), and plasma pre-operative orosomucoid levels (OR 1.008 (1.206-5.761). After studying differences regarding sex, orosomucoid was the best predictor for POAF in women (OR 2.639 (95% CI, 1.455-4.788),
= 0.027) but not in men. The results support the pre-operative inflammation pathway as a factor involved in the risk of POAF, mainly in women. |
| doi_str_mv | 10.3390/jcm12103565 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10219332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A752657857</galeid><sourcerecordid>A752657857</sourcerecordid><originalsourceid>FETCH-LOGICAL-c435t-eecc75bbd3372502fe6cc419a31a3d9ca9c4487fcec05adbe8553e868fe196123</originalsourceid><addsrcrecordid>eNptUk1v3CAQRVWrJkpz6r2y1EulyikfxuBTtVk1H1KkRGpzRhjGLlsbtmBHSn99cZKmmyhwYAbee8yDQeg9wUeMNfjLxoyEEsx4zV-hfYqFKDGT7PVOvIcOU9rgPKSsKBFv0R4TtMK1oPvoz3pw3hk9FFcxdC4nfaG9LY5dGHX8BTEVXYjFVUhTebmFqCd3A8Vqii5TTlwb3TDkveAzH6wzd6HLWd4EP6Xi2luIfVh01zpap03xfY49xNt36E2nhwSHD-sBuj759mN9Vl5cnp6vVxelqRifSgBjBG9by3LVHNMOamMq0mhGNLON0Y2pKik6AwZzbVuQnDOQteyANDWh7AB9vdfdzu0I1uSyoh7UNrrs8FYF7dTTE-9-qj7cKIIpaRhbFD49KMTwe4Y0qdElA9m5hzAnRSXFmFaVEBn68Rl0E-bos7-MIk3FKW_4f1SvB1DOdyFfbBZRtRKc1lxIvmgdvYDK08LoTPCQ_wueEj7fE0wMKUXoHk0SrJZ2UTvtktEfdt_lEfuvOdhfswu7qA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2819452595</pqid></control><display><type>article</type><title>Clinical Profiling and Biomarkers for Post-Operative Atrial Fibrillation Prediction in Patients Undergoing Cardiac Surgery</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Iglesias-Álvarez, Diego ; Fu, Xiaoran ; Martínez-Cereijo, José Manuel ; Agra-Bermejo, Rosa María ; Veiras-Del Río, Sonia ; Selas-Cobos, Salomé ; Rial-Munin, María Victoria ; Eiras-Mariño, María ; Martínez-Salgado, Adrián ; Taboada-Muñiz, Manuel ; Reija-López, Laura ; Souaf, Souhayla ; García-Carro, Javier ; Fernández-González, Ángel Luis ; Adrio-Nazar, Belén ; González-Juanatey, José Ramón ; Eiras, Sonia ; Rodríguez-Mañero, Moisés</creator><creatorcontrib>Iglesias-Álvarez, Diego ; Fu, Xiaoran ; Martínez-Cereijo, José Manuel ; Agra-Bermejo, Rosa María ; Veiras-Del Río, Sonia ; Selas-Cobos, Salomé ; Rial-Munin, María Victoria ; Eiras-Mariño, María ; Martínez-Salgado, Adrián ; Taboada-Muñiz, Manuel ; Reija-López, Laura ; Souaf, Souhayla ; García-Carro, Javier ; Fernández-González, Ángel Luis ; Adrio-Nazar, Belén ; González-Juanatey, José Ramón ; Eiras, Sonia ; Rodríguez-Mañero, Moisés</creatorcontrib><description>Post-operative atrial fibrillation (POAF) is the most common arrhythmia in the post-operative period after cardiac surgery. We aim to investigate the main clinical, local, and/or peripheral biochemical and molecular predictors for POAF in patients undergoing coronary and/or valve surgery. Between August 2020 and September 2022, consecutive patients undergoing cardiac surgery without previous history of AF were studied. Clinical variables, plasma, and biological tissues (epicardial and subcutaneous fat) were obtained before surgery. Pre-operative markers associated with inflammation, adiposity, atrial stretch, and fibrosis were analyzed on peripheral and local samples with multiplex assay and real-time PCR. Univariate and multivariate logistic regression analyses were performed in order to identify the main predictors for POAF. Patients were followed-up until hospital discharge. Out of 123 consecutive patients without prior AF, 43 (34.9%) developed POAF during hospitalization. The main predictors were cardiopulmonary bypass time (odds ratio (OR) 1.008 (95% confidence interval (CI), 1.002-1.013),
= 0.005), and plasma pre-operative orosomucoid levels (OR 1.008 (1.206-5.761). After studying differences regarding sex, orosomucoid was the best predictor for POAF in women (OR 2.639 (95% CI, 1.455-4.788),
= 0.027) but not in men. The results support the pre-operative inflammation pathway as a factor involved in the risk of POAF, mainly in women.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12103565</identifier><identifier>PMID: 37240672</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Atrial fibrillation ; Biological markers ; Biomarkers ; Biopsy ; Blood ; Cardiac arrhythmia ; Cardiology ; Clinical medicine ; Complications ; Cytokines ; Electrocardiography ; Electrolytes ; Heart ; Heart surgery ; Hospitalization ; Hospitals ; Inflammation ; Length of stay ; Life sciences ; Medical laboratories ; Metabolism ; Neutrophils ; Patients ; Risk factors ; Surgery ; Surgery, Experimental ; Surgical research</subject><ispartof>Journal of clinical medicine, 2023-05, Vol.12 (10), p.3565</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c435t-eecc75bbd3372502fe6cc419a31a3d9ca9c4487fcec05adbe8553e868fe196123</cites><orcidid>0000-0001-7073-1835 ; 0000-0001-7566-9321 ; 0000-0001-7200-253X ; 0000-0001-5260-5309 ; 0000-0001-9681-3388</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219332/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219332/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37240672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Iglesias-Álvarez, Diego</creatorcontrib><creatorcontrib>Fu, Xiaoran</creatorcontrib><creatorcontrib>Martínez-Cereijo, José Manuel</creatorcontrib><creatorcontrib>Agra-Bermejo, Rosa María</creatorcontrib><creatorcontrib>Veiras-Del Río, Sonia</creatorcontrib><creatorcontrib>Selas-Cobos, Salomé</creatorcontrib><creatorcontrib>Rial-Munin, María Victoria</creatorcontrib><creatorcontrib>Eiras-Mariño, María</creatorcontrib><creatorcontrib>Martínez-Salgado, Adrián</creatorcontrib><creatorcontrib>Taboada-Muñiz, Manuel</creatorcontrib><creatorcontrib>Reija-López, Laura</creatorcontrib><creatorcontrib>Souaf, Souhayla</creatorcontrib><creatorcontrib>García-Carro, Javier</creatorcontrib><creatorcontrib>Fernández-González, Ángel Luis</creatorcontrib><creatorcontrib>Adrio-Nazar, Belén</creatorcontrib><creatorcontrib>González-Juanatey, José Ramón</creatorcontrib><creatorcontrib>Eiras, Sonia</creatorcontrib><creatorcontrib>Rodríguez-Mañero, Moisés</creatorcontrib><title>Clinical Profiling and Biomarkers for Post-Operative Atrial Fibrillation Prediction in Patients Undergoing Cardiac Surgery</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Post-operative atrial fibrillation (POAF) is the most common arrhythmia in the post-operative period after cardiac surgery. We aim to investigate the main clinical, local, and/or peripheral biochemical and molecular predictors for POAF in patients undergoing coronary and/or valve surgery. Between August 2020 and September 2022, consecutive patients undergoing cardiac surgery without previous history of AF were studied. Clinical variables, plasma, and biological tissues (epicardial and subcutaneous fat) were obtained before surgery. Pre-operative markers associated with inflammation, adiposity, atrial stretch, and fibrosis were analyzed on peripheral and local samples with multiplex assay and real-time PCR. Univariate and multivariate logistic regression analyses were performed in order to identify the main predictors for POAF. Patients were followed-up until hospital discharge. Out of 123 consecutive patients without prior AF, 43 (34.9%) developed POAF during hospitalization. The main predictors were cardiopulmonary bypass time (odds ratio (OR) 1.008 (95% confidence interval (CI), 1.002-1.013),
= 0.005), and plasma pre-operative orosomucoid levels (OR 1.008 (1.206-5.761). After studying differences regarding sex, orosomucoid was the best predictor for POAF in women (OR 2.639 (95% CI, 1.455-4.788),
= 0.027) but not in men. The results support the pre-operative inflammation pathway as a factor involved in the risk of POAF, mainly in women.</description><subject>Atrial fibrillation</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Clinical medicine</subject><subject>Complications</subject><subject>Cytokines</subject><subject>Electrocardiography</subject><subject>Electrolytes</subject><subject>Heart</subject><subject>Heart surgery</subject><subject>Hospitalization</subject><subject>Hospitals</subject><subject>Inflammation</subject><subject>Length of stay</subject><subject>Life sciences</subject><subject>Medical laboratories</subject><subject>Metabolism</subject><subject>Neutrophils</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Surgery, Experimental</subject><subject>Surgical research</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUk1v3CAQRVWrJkpz6r2y1EulyikfxuBTtVk1H1KkRGpzRhjGLlsbtmBHSn99cZKmmyhwYAbee8yDQeg9wUeMNfjLxoyEEsx4zV-hfYqFKDGT7PVOvIcOU9rgPKSsKBFv0R4TtMK1oPvoz3pw3hk9FFcxdC4nfaG9LY5dGHX8BTEVXYjFVUhTebmFqCd3A8Vqii5TTlwb3TDkveAzH6wzd6HLWd4EP6Xi2luIfVh01zpap03xfY49xNt36E2nhwSHD-sBuj759mN9Vl5cnp6vVxelqRifSgBjBG9by3LVHNMOamMq0mhGNLON0Y2pKik6AwZzbVuQnDOQteyANDWh7AB9vdfdzu0I1uSyoh7UNrrs8FYF7dTTE-9-qj7cKIIpaRhbFD49KMTwe4Y0qdElA9m5hzAnRSXFmFaVEBn68Rl0E-bos7-MIk3FKW_4f1SvB1DOdyFfbBZRtRKc1lxIvmgdvYDK08LoTPCQ_wueEj7fE0wMKUXoHk0SrJZ2UTvtktEfdt_lEfuvOdhfswu7qA</recordid><startdate>20230519</startdate><enddate>20230519</enddate><creator>Iglesias-Álvarez, Diego</creator><creator>Fu, Xiaoran</creator><creator>Martínez-Cereijo, José Manuel</creator><creator>Agra-Bermejo, Rosa María</creator><creator>Veiras-Del Río, Sonia</creator><creator>Selas-Cobos, Salomé</creator><creator>Rial-Munin, María Victoria</creator><creator>Eiras-Mariño, María</creator><creator>Martínez-Salgado, Adrián</creator><creator>Taboada-Muñiz, Manuel</creator><creator>Reija-López, Laura</creator><creator>Souaf, Souhayla</creator><creator>García-Carro, Javier</creator><creator>Fernández-González, Ángel Luis</creator><creator>Adrio-Nazar, Belén</creator><creator>González-Juanatey, José Ramón</creator><creator>Eiras, Sonia</creator><creator>Rodríguez-Mañero, Moisés</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7073-1835</orcidid><orcidid>https://orcid.org/0000-0001-7566-9321</orcidid><orcidid>https://orcid.org/0000-0001-7200-253X</orcidid><orcidid>https://orcid.org/0000-0001-5260-5309</orcidid><orcidid>https://orcid.org/0000-0001-9681-3388</orcidid></search><sort><creationdate>20230519</creationdate><title>Clinical Profiling and Biomarkers for Post-Operative Atrial Fibrillation Prediction in Patients Undergoing Cardiac Surgery</title><author>Iglesias-Álvarez, Diego ; Fu, Xiaoran ; Martínez-Cereijo, José Manuel ; Agra-Bermejo, Rosa María ; Veiras-Del Río, Sonia ; Selas-Cobos, Salomé ; Rial-Munin, María Victoria ; Eiras-Mariño, María ; Martínez-Salgado, Adrián ; Taboada-Muñiz, Manuel ; Reija-López, Laura ; Souaf, Souhayla ; García-Carro, Javier ; Fernández-González, Ángel Luis ; Adrio-Nazar, Belén ; González-Juanatey, José Ramón ; Eiras, Sonia ; Rodríguez-Mañero, Moisés</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-eecc75bbd3372502fe6cc419a31a3d9ca9c4487fcec05adbe8553e868fe196123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Atrial fibrillation</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biopsy</topic><topic>Blood</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Clinical medicine</topic><topic>Complications</topic><topic>Cytokines</topic><topic>Electrocardiography</topic><topic>Electrolytes</topic><topic>Heart</topic><topic>Heart surgery</topic><topic>Hospitalization</topic><topic>Hospitals</topic><topic>Inflammation</topic><topic>Length of stay</topic><topic>Life sciences</topic><topic>Medical laboratories</topic><topic>Metabolism</topic><topic>Neutrophils</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Surgery, Experimental</topic><topic>Surgical research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Iglesias-Álvarez, Diego</creatorcontrib><creatorcontrib>Fu, Xiaoran</creatorcontrib><creatorcontrib>Martínez-Cereijo, José Manuel</creatorcontrib><creatorcontrib>Agra-Bermejo, Rosa María</creatorcontrib><creatorcontrib>Veiras-Del Río, Sonia</creatorcontrib><creatorcontrib>Selas-Cobos, Salomé</creatorcontrib><creatorcontrib>Rial-Munin, María Victoria</creatorcontrib><creatorcontrib>Eiras-Mariño, María</creatorcontrib><creatorcontrib>Martínez-Salgado, Adrián</creatorcontrib><creatorcontrib>Taboada-Muñiz, Manuel</creatorcontrib><creatorcontrib>Reija-López, Laura</creatorcontrib><creatorcontrib>Souaf, Souhayla</creatorcontrib><creatorcontrib>García-Carro, Javier</creatorcontrib><creatorcontrib>Fernández-González, Ángel Luis</creatorcontrib><creatorcontrib>Adrio-Nazar, Belén</creatorcontrib><creatorcontrib>González-Juanatey, José Ramón</creatorcontrib><creatorcontrib>Eiras, Sonia</creatorcontrib><creatorcontrib>Rodríguez-Mañero, Moisés</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iglesias-Álvarez, Diego</au><au>Fu, Xiaoran</au><au>Martínez-Cereijo, José Manuel</au><au>Agra-Bermejo, Rosa María</au><au>Veiras-Del Río, Sonia</au><au>Selas-Cobos, Salomé</au><au>Rial-Munin, María Victoria</au><au>Eiras-Mariño, María</au><au>Martínez-Salgado, Adrián</au><au>Taboada-Muñiz, Manuel</au><au>Reija-López, Laura</au><au>Souaf, Souhayla</au><au>García-Carro, Javier</au><au>Fernández-González, Ángel Luis</au><au>Adrio-Nazar, Belén</au><au>González-Juanatey, José Ramón</au><au>Eiras, Sonia</au><au>Rodríguez-Mañero, Moisés</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Profiling and Biomarkers for Post-Operative Atrial Fibrillation Prediction in Patients Undergoing Cardiac Surgery</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2023-05-19</date><risdate>2023</risdate><volume>12</volume><issue>10</issue><spage>3565</spage><pages>3565-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Post-operative atrial fibrillation (POAF) is the most common arrhythmia in the post-operative period after cardiac surgery. We aim to investigate the main clinical, local, and/or peripheral biochemical and molecular predictors for POAF in patients undergoing coronary and/or valve surgery. Between August 2020 and September 2022, consecutive patients undergoing cardiac surgery without previous history of AF were studied. Clinical variables, plasma, and biological tissues (epicardial and subcutaneous fat) were obtained before surgery. Pre-operative markers associated with inflammation, adiposity, atrial stretch, and fibrosis were analyzed on peripheral and local samples with multiplex assay and real-time PCR. Univariate and multivariate logistic regression analyses were performed in order to identify the main predictors for POAF. Patients were followed-up until hospital discharge. Out of 123 consecutive patients without prior AF, 43 (34.9%) developed POAF during hospitalization. The main predictors were cardiopulmonary bypass time (odds ratio (OR) 1.008 (95% confidence interval (CI), 1.002-1.013),
= 0.005), and plasma pre-operative orosomucoid levels (OR 1.008 (1.206-5.761). After studying differences regarding sex, orosomucoid was the best predictor for POAF in women (OR 2.639 (95% CI, 1.455-4.788),
= 0.027) but not in men. The results support the pre-operative inflammation pathway as a factor involved in the risk of POAF, mainly in women.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37240672</pmid><doi>10.3390/jcm12103565</doi><orcidid>https://orcid.org/0000-0001-7073-1835</orcidid><orcidid>https://orcid.org/0000-0001-7566-9321</orcidid><orcidid>https://orcid.org/0000-0001-7200-253X</orcidid><orcidid>https://orcid.org/0000-0001-5260-5309</orcidid><orcidid>https://orcid.org/0000-0001-9681-3388</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2077-0383 |
| ispartof | Journal of clinical medicine, 2023-05, Vol.12 (10), p.3565 |
| issn | 2077-0383 2077-0383 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10219332 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central |
| subjects | Atrial fibrillation Biological markers Biomarkers Biopsy Blood Cardiac arrhythmia Cardiology Clinical medicine Complications Cytokines Electrocardiography Electrolytes Heart Heart surgery Hospitalization Hospitals Inflammation Length of stay Life sciences Medical laboratories Metabolism Neutrophils Patients Risk factors Surgery Surgery, Experimental Surgical research |
| title | Clinical Profiling and Biomarkers for Post-Operative Atrial Fibrillation Prediction in Patients Undergoing Cardiac Surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-04T22%3A09%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20Profiling%20and%20Biomarkers%20for%20Post-Operative%20Atrial%20Fibrillation%20Prediction%20in%20Patients%20Undergoing%20Cardiac%20Surgery&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Iglesias-%C3%81lvarez,%20Diego&rft.date=2023-05-19&rft.volume=12&rft.issue=10&rft.spage=3565&rft.pages=3565-&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm12103565&rft_dat=%3Cgale_pubme%3EA752657857%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2819452595&rft_id=info:pmid/37240672&rft_galeid=A752657857&rfr_iscdi=true |