Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads
The sex chromosomes of birds are designated Z and W. The male is homogamous (ZZ), and the female is heterogamous (ZW). The chicken W chromosome is a degenerate version of the Z chromosome and harbors only 28 protein-coding genes. We studied the expression pattern of the W chromosome gene (showing di...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2023-05, Vol.24 (10), p.8891 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 10 |
| container_start_page | 8891 |
| container_title | International journal of molecular sciences |
| container_volume | 24 |
| creator | Lin, Xiao Jin, Zidi Li, Shuo Zheng, Mingde Xing, Ya Liu, Xikui Lv, Mengqing Zhao, Minmeng Geng, Tuoyu Gong, Daoqing Zhao, Debiao Liu, Long |
| description | The sex chromosomes of birds are designated Z and W. The male is homogamous (ZZ), and the female is heterogamous (ZW). The chicken W chromosome is a degenerate version of the Z chromosome and harbors only 28 protein-coding genes. We studied the expression pattern of the W chromosome gene
(showing differential expression during gonadogenesis) in chicken embryonic gonads and its potential role in gonadal development. The W copy of
(
) shows a gonad-biased expression in chicken embryonic tissues which was different from its Z copy. The overall expression of
and
mRNA and protein is correlated with the gonadal phenotype being higher in female gonads than in male gonads or female-to-male sex-reversed gonads. Chicken MIER3 protein is highly expressed in the nucleus, with relatively lower expression in the cytoplasm. Overexpression of
in male gonad cells suggested its effect on the GnRH signaling pathway, cell proliferation, and cell apoptosis.
expression is associated with the gonadal phenotype.
may promote female gonadal development by regulating
and
genes. These findings enrich our knowledge of chicken W chromosome genes and support a more systematic and in-depth understanding of gonadal development in chickens. |
| doi_str_mv | 10.3390/ijms24108891 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10218813</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2820020617</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-37d9814ca892e900f8cdbf9ca95ee0f98e1583e2f733d96f3b64eb98bfd9b4063</originalsourceid><addsrcrecordid>eNpdkUtrGzEUhUVJaF7ddV0E2XQRJ3p5RlqVYhw3kJDSJHQpNJqrWO6M5Egzpf73VcgDJysdcT8O99yD0GdKTjlX5Myv-swEJVIq-gHtU8HYhJCq3tnSe-gg5xUhjLOp-oj2eM0EYYLto_ufCTrf-2DSBt8MY7vBMeD5v3WCnH2RJrT4fAx2ePxEh4cl4NnS2z8Q8O-iUuxjjj3gBQTAVxfzXxz74tA3aRODt3gRg2nzEdp1psvw6fk9RHfn89vZj8nl9eJi9v1yYnlNhgmvWyWpsEYqBooQJ23bOGWNmgIQpyTQqeTAXM15qyrHm0pAo2TjWtUIUvFD9O3Jdz02PbQWwpBMp9fJ9yWhjsbrt5Pgl_o-_tWUMCol5cXh67NDig8j5EH3PlvoOhMgjlkzycohSUXrgh6_Q1dxTKHkKxRVYiqoUoU6eaJsijkncK_bUKIfK9TbFRb8y3aCV_ilM_4f0QGXyg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2819454199</pqid></control><display><type>article</type><title>Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Lin, Xiao ; Jin, Zidi ; Li, Shuo ; Zheng, Mingde ; Xing, Ya ; Liu, Xikui ; Lv, Mengqing ; Zhao, Minmeng ; Geng, Tuoyu ; Gong, Daoqing ; Zhao, Debiao ; Liu, Long</creator><creatorcontrib>Lin, Xiao ; Jin, Zidi ; Li, Shuo ; Zheng, Mingde ; Xing, Ya ; Liu, Xikui ; Lv, Mengqing ; Zhao, Minmeng ; Geng, Tuoyu ; Gong, Daoqing ; Zhao, Debiao ; Liu, Long</creatorcontrib><description>The sex chromosomes of birds are designated Z and W. The male is homogamous (ZZ), and the female is heterogamous (ZW). The chicken W chromosome is a degenerate version of the Z chromosome and harbors only 28 protein-coding genes. We studied the expression pattern of the W chromosome gene
(showing differential expression during gonadogenesis) in chicken embryonic gonads and its potential role in gonadal development. The W copy of
(
) shows a gonad-biased expression in chicken embryonic tissues which was different from its Z copy. The overall expression of
and
mRNA and protein is correlated with the gonadal phenotype being higher in female gonads than in male gonads or female-to-male sex-reversed gonads. Chicken MIER3 protein is highly expressed in the nucleus, with relatively lower expression in the cytoplasm. Overexpression of
in male gonad cells suggested its effect on the GnRH signaling pathway, cell proliferation, and cell apoptosis.
expression is associated with the gonadal phenotype.
may promote female gonadal development by regulating
and
genes. These findings enrich our knowledge of chicken W chromosome genes and support a more systematic and in-depth understanding of gonadal development in chickens.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24108891</identifier><identifier>PMID: 37240242</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amino acids ; Animals ; Apoptosis ; Cell proliferation ; Chick Embryo ; Chickens ; Chickens - genetics ; Chromosomes ; Cytoplasm ; EGR-1 protein ; Embryogenesis ; Female ; Females ; Gene expression ; Gene Expression Regulation, Developmental ; Genes ; Gonadotropin-releasing hormone ; Gonads ; Gonads - metabolism ; Localization ; Male ; Males ; mRNA ; Ovaries ; Phenotypes ; Phylogenetics ; Poultry ; Proteins ; Reptiles & amphibians ; Sex chromosomes ; Sex Chromosomes - genetics ; Sex Determination Processes - genetics ; Signal transduction ; W chromosomes ; Z chromosomes</subject><ispartof>International journal of molecular sciences, 2023-05, Vol.24 (10), p.8891</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-37d9814ca892e900f8cdbf9ca95ee0f98e1583e2f733d96f3b64eb98bfd9b4063</cites><orcidid>0000-0003-2967-8440</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218813/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218813/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37240242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Xiao</creatorcontrib><creatorcontrib>Jin, Zidi</creatorcontrib><creatorcontrib>Li, Shuo</creatorcontrib><creatorcontrib>Zheng, Mingde</creatorcontrib><creatorcontrib>Xing, Ya</creatorcontrib><creatorcontrib>Liu, Xikui</creatorcontrib><creatorcontrib>Lv, Mengqing</creatorcontrib><creatorcontrib>Zhao, Minmeng</creatorcontrib><creatorcontrib>Geng, Tuoyu</creatorcontrib><creatorcontrib>Gong, Daoqing</creatorcontrib><creatorcontrib>Zhao, Debiao</creatorcontrib><creatorcontrib>Liu, Long</creatorcontrib><title>Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The sex chromosomes of birds are designated Z and W. The male is homogamous (ZZ), and the female is heterogamous (ZW). The chicken W chromosome is a degenerate version of the Z chromosome and harbors only 28 protein-coding genes. We studied the expression pattern of the W chromosome gene
(showing differential expression during gonadogenesis) in chicken embryonic gonads and its potential role in gonadal development. The W copy of
(
) shows a gonad-biased expression in chicken embryonic tissues which was different from its Z copy. The overall expression of
and
mRNA and protein is correlated with the gonadal phenotype being higher in female gonads than in male gonads or female-to-male sex-reversed gonads. Chicken MIER3 protein is highly expressed in the nucleus, with relatively lower expression in the cytoplasm. Overexpression of
in male gonad cells suggested its effect on the GnRH signaling pathway, cell proliferation, and cell apoptosis.
expression is associated with the gonadal phenotype.
may promote female gonadal development by regulating
and
genes. These findings enrich our knowledge of chicken W chromosome genes and support a more systematic and in-depth understanding of gonadal development in chickens.</description><subject>Amino acids</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cell proliferation</subject><subject>Chick Embryo</subject><subject>Chickens</subject><subject>Chickens - genetics</subject><subject>Chromosomes</subject><subject>Cytoplasm</subject><subject>EGR-1 protein</subject><subject>Embryogenesis</subject><subject>Female</subject><subject>Females</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Gonadotropin-releasing hormone</subject><subject>Gonads</subject><subject>Gonads - metabolism</subject><subject>Localization</subject><subject>Male</subject><subject>Males</subject><subject>mRNA</subject><subject>Ovaries</subject><subject>Phenotypes</subject><subject>Phylogenetics</subject><subject>Poultry</subject><subject>Proteins</subject><subject>Reptiles & amphibians</subject><subject>Sex chromosomes</subject><subject>Sex Chromosomes - genetics</subject><subject>Sex Determination Processes - genetics</subject><subject>Signal transduction</subject><subject>W chromosomes</subject><subject>Z chromosomes</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtrGzEUhUVJaF7ddV0E2XQRJ3p5RlqVYhw3kJDSJHQpNJqrWO6M5Egzpf73VcgDJysdcT8O99yD0GdKTjlX5Myv-swEJVIq-gHtU8HYhJCq3tnSe-gg5xUhjLOp-oj2eM0EYYLto_ufCTrf-2DSBt8MY7vBMeD5v3WCnH2RJrT4fAx2ePxEh4cl4NnS2z8Q8O-iUuxjjj3gBQTAVxfzXxz74tA3aRODt3gRg2nzEdp1psvw6fk9RHfn89vZj8nl9eJi9v1yYnlNhgmvWyWpsEYqBooQJ23bOGWNmgIQpyTQqeTAXM15qyrHm0pAo2TjWtUIUvFD9O3Jdz02PbQWwpBMp9fJ9yWhjsbrt5Pgl_o-_tWUMCol5cXh67NDig8j5EH3PlvoOhMgjlkzycohSUXrgh6_Q1dxTKHkKxRVYiqoUoU6eaJsijkncK_bUKIfK9TbFRb8y3aCV_ilM_4f0QGXyg</recordid><startdate>20230517</startdate><enddate>20230517</enddate><creator>Lin, Xiao</creator><creator>Jin, Zidi</creator><creator>Li, Shuo</creator><creator>Zheng, Mingde</creator><creator>Xing, Ya</creator><creator>Liu, Xikui</creator><creator>Lv, Mengqing</creator><creator>Zhao, Minmeng</creator><creator>Geng, Tuoyu</creator><creator>Gong, Daoqing</creator><creator>Zhao, Debiao</creator><creator>Liu, Long</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2967-8440</orcidid></search><sort><creationdate>20230517</creationdate><title>Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads</title><author>Lin, Xiao ; Jin, Zidi ; Li, Shuo ; Zheng, Mingde ; Xing, Ya ; Liu, Xikui ; Lv, Mengqing ; Zhao, Minmeng ; Geng, Tuoyu ; Gong, Daoqing ; Zhao, Debiao ; Liu, Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-37d9814ca892e900f8cdbf9ca95ee0f98e1583e2f733d96f3b64eb98bfd9b4063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Amino acids</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Cell proliferation</topic><topic>Chick Embryo</topic><topic>Chickens</topic><topic>Chickens - genetics</topic><topic>Chromosomes</topic><topic>Cytoplasm</topic><topic>EGR-1 protein</topic><topic>Embryogenesis</topic><topic>Female</topic><topic>Females</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genes</topic><topic>Gonadotropin-releasing hormone</topic><topic>Gonads</topic><topic>Gonads - metabolism</topic><topic>Localization</topic><topic>Male</topic><topic>Males</topic><topic>mRNA</topic><topic>Ovaries</topic><topic>Phenotypes</topic><topic>Phylogenetics</topic><topic>Poultry</topic><topic>Proteins</topic><topic>Reptiles & amphibians</topic><topic>Sex chromosomes</topic><topic>Sex Chromosomes - genetics</topic><topic>Sex Determination Processes - genetics</topic><topic>Signal transduction</topic><topic>W chromosomes</topic><topic>Z chromosomes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Xiao</creatorcontrib><creatorcontrib>Jin, Zidi</creatorcontrib><creatorcontrib>Li, Shuo</creatorcontrib><creatorcontrib>Zheng, Mingde</creatorcontrib><creatorcontrib>Xing, Ya</creatorcontrib><creatorcontrib>Liu, Xikui</creatorcontrib><creatorcontrib>Lv, Mengqing</creatorcontrib><creatorcontrib>Zhao, Minmeng</creatorcontrib><creatorcontrib>Geng, Tuoyu</creatorcontrib><creatorcontrib>Gong, Daoqing</creatorcontrib><creatorcontrib>Zhao, Debiao</creatorcontrib><creatorcontrib>Liu, Long</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Xiao</au><au>Jin, Zidi</au><au>Li, Shuo</au><au>Zheng, Mingde</au><au>Xing, Ya</au><au>Liu, Xikui</au><au>Lv, Mengqing</au><au>Zhao, Minmeng</au><au>Geng, Tuoyu</au><au>Gong, Daoqing</au><au>Zhao, Debiao</au><au>Liu, Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-05-17</date><risdate>2023</risdate><volume>24</volume><issue>10</issue><spage>8891</spage><pages>8891-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The sex chromosomes of birds are designated Z and W. The male is homogamous (ZZ), and the female is heterogamous (ZW). The chicken W chromosome is a degenerate version of the Z chromosome and harbors only 28 protein-coding genes. We studied the expression pattern of the W chromosome gene
(showing differential expression during gonadogenesis) in chicken embryonic gonads and its potential role in gonadal development. The W copy of
(
) shows a gonad-biased expression in chicken embryonic tissues which was different from its Z copy. The overall expression of
and
mRNA and protein is correlated with the gonadal phenotype being higher in female gonads than in male gonads or female-to-male sex-reversed gonads. Chicken MIER3 protein is highly expressed in the nucleus, with relatively lower expression in the cytoplasm. Overexpression of
in male gonad cells suggested its effect on the GnRH signaling pathway, cell proliferation, and cell apoptosis.
expression is associated with the gonadal phenotype.
may promote female gonadal development by regulating
and
genes. These findings enrich our knowledge of chicken W chromosome genes and support a more systematic and in-depth understanding of gonadal development in chickens.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37240242</pmid><doi>10.3390/ijms24108891</doi><orcidid>https://orcid.org/0000-0003-2967-8440</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2023-05, Vol.24 (10), p.8891 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10218813 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino acids Animals Apoptosis Cell proliferation Chick Embryo Chickens Chickens - genetics Chromosomes Cytoplasm EGR-1 protein Embryogenesis Female Females Gene expression Gene Expression Regulation, Developmental Genes Gonadotropin-releasing hormone Gonads Gonads - metabolism Localization Male Males mRNA Ovaries Phenotypes Phylogenetics Poultry Proteins Reptiles & amphibians Sex chromosomes Sex Chromosomes - genetics Sex Determination Processes - genetics Signal transduction W chromosomes Z chromosomes |
| title | Preliminary Study on Expression and Function of the Chicken W Chromosome Gene MIER3 in Embryonic Gonads |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T01%3A55%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preliminary%20Study%20on%20Expression%20and%20Function%20of%20the%20Chicken%20W%20Chromosome%20Gene%20MIER3%20in%20Embryonic%20Gonads&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Lin,%20Xiao&rft.date=2023-05-17&rft.volume=24&rft.issue=10&rft.spage=8891&rft.pages=8891-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms24108891&rft_dat=%3Cproquest_pubme%3E2820020617%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2819454199&rft_id=info:pmid/37240242&rfr_iscdi=true |