Sambucus ebulus (Elderberry) Fruits Modulate Inflammation and Complement System Activity in Humans
(SE) fruits are used for immune stimulation and amelioration of gastrointestinal inflammatory conditions. Currently, there is no scientific evidence of their effects on various aspects of the immune response mechanisms in humans. The purpose of this study was to evaluate the immunomodulatory potenti...
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| Veröffentlicht in: | International journal of molecular sciences 2023-05, Vol.24 (10), p.8714 |
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| creator | Kiselova-Kaneva, Yoana Nashar, Milka Roussev, Bogdan Salim, Ayshe Hristova, Minka Olczyk, Pawel Komosinska-Vassev, Katarzyna Dincheva, Ivayla Badjakov, Ilian Galunska, Bistra Ivanova, Diana |
| description | (SE) fruits are used for immune stimulation and amelioration of gastrointestinal inflammatory conditions. Currently, there is no scientific evidence of their effects on various aspects of the immune response mechanisms in humans. The purpose of this study was to evaluate the immunomodulatory potential of SE fruit infusion intake in healthy humans. Anthocyanin content was determined with UPLC-ESI-MS/MS. Fifty-three volunteers enrolled in a 4-week SE infusion intake intervention. Blood count, serum total protein, Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), Tumor Necrosis Factor Alpha (TNFα), High-sensitivity C-reactive protein (hs-CRP), C3, and C4 levels were measured on automatic analyzers, and Interleukin 8 (IL-8) was measured manually with an ELISA kit. Cyanidin-3-O-galactoside (48.15 mg/g DW), followed by cyaniding-3-sambubioside (43.41 ± 1.07 mg/g DW), were the most abundant anthocyanins in SE samples. A significant decrease in total protein (2.82%), IL-6 (20.15%), TNFα (5.38%), IL-8 (5.50%), C3 (4.16%), and C4 (14.29%) was established in the whole group. Total protein, IL-8, TNFα, and C4 decreased in women (3.11%, 4.76%, 5.09%, and 11.11%), and IL-6 decreased (40.61%) in men. Hb (1.20%) and hematocrit (1.55%) levels decreased in the whole group and in the women group (1.61% and 2.20%). SE fruits exert immune-modulatory activity as revealed by decreased pro-inflammatory status and complement activity markers in healthy volunteers after a 4-week intervention. |
| doi_str_mv | 10.3390/ijms24108714 |
| format | Article |
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Currently, there is no scientific evidence of their effects on various aspects of the immune response mechanisms in humans. The purpose of this study was to evaluate the immunomodulatory potential of SE fruit infusion intake in healthy humans. Anthocyanin content was determined with UPLC-ESI-MS/MS. Fifty-three volunteers enrolled in a 4-week SE infusion intake intervention. Blood count, serum total protein, Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), Tumor Necrosis Factor Alpha (TNFα), High-sensitivity C-reactive protein (hs-CRP), C3, and C4 levels were measured on automatic analyzers, and Interleukin 8 (IL-8) was measured manually with an ELISA kit. Cyanidin-3-O-galactoside (48.15 mg/g DW), followed by cyaniding-3-sambubioside (43.41 ± 1.07 mg/g DW), were the most abundant anthocyanins in SE samples. A significant decrease in total protein (2.82%), IL-6 (20.15%), TNFα (5.38%), IL-8 (5.50%), C3 (4.16%), and C4 (14.29%) was established in the whole group. Total protein, IL-8, TNFα, and C4 decreased in women (3.11%, 4.76%, 5.09%, and 11.11%), and IL-6 decreased (40.61%) in men. Hb (1.20%) and hematocrit (1.55%) levels decreased in the whole group and in the women group (1.61% and 2.20%). SE fruits exert immune-modulatory activity as revealed by decreased pro-inflammatory status and complement activity markers in healthy volunteers after a 4-week intervention.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24108714</identifier><identifier>PMID: 37240060</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Analyzers ; Anthocyanins ; Anthocyanins - analysis ; C-reactive protein ; Cell culture ; Complement component C3 ; Complement component C4 ; Complement system ; Coronaviruses ; COVID-19 ; Cyaniding ; Cytokine storm ; Cytotoxicity ; Enzyme-linked immunosorbent assay ; Female ; Flavonoids ; Folk medicine ; Fruit - chemistry ; Fruits ; Galactosides ; Gender ; Hematocrit ; Hematology ; Herbal medicine ; Herpes viruses ; Humans ; Immune response ; Immune system ; Immunomodulation ; Immunomodulators ; Inflammation ; Influenza ; Interleukin 1 ; Interleukin 6 ; Interleukin 8 ; Male ; Medicine ; Metabolites ; Pandemics ; Phytochemicals ; Proteins ; Rheumatoid arthritis ; Sambucus ; Sambucus ebulus ; Serum proteins ; Severe acute respiratory syndrome coronavirus 2 ; Tandem Mass Spectrometry ; Tumor Necrosis Factor-alpha ; Tumor necrosis factor-α ; Viral infections ; Womens health</subject><ispartof>International journal of molecular sciences, 2023-05, Vol.24 (10), p.8714</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-55fac09137975a814555627b473acbd9d862e8b753a0432e3353daeb48496aad3</citedby><cites>FETCH-LOGICAL-c413t-55fac09137975a814555627b473acbd9d862e8b753a0432e3353daeb48496aad3</cites><orcidid>0000-0001-9692-6227 ; 0000-0003-0526-3996 ; 0000-0001-7387-9587 ; 0000-0003-2307-5884 ; 0000-0002-1422-7121 ; 0000-0003-0276-4170 ; 0000-0003-3964-6039 ; 0000-0002-4502-081X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218470/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218470/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37240060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiselova-Kaneva, Yoana</creatorcontrib><creatorcontrib>Nashar, Milka</creatorcontrib><creatorcontrib>Roussev, Bogdan</creatorcontrib><creatorcontrib>Salim, Ayshe</creatorcontrib><creatorcontrib>Hristova, Minka</creatorcontrib><creatorcontrib>Olczyk, Pawel</creatorcontrib><creatorcontrib>Komosinska-Vassev, Katarzyna</creatorcontrib><creatorcontrib>Dincheva, Ivayla</creatorcontrib><creatorcontrib>Badjakov, Ilian</creatorcontrib><creatorcontrib>Galunska, Bistra</creatorcontrib><creatorcontrib>Ivanova, Diana</creatorcontrib><title>Sambucus ebulus (Elderberry) Fruits Modulate Inflammation and Complement System Activity in Humans</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>(SE) fruits are used for immune stimulation and amelioration of gastrointestinal inflammatory conditions. Currently, there is no scientific evidence of their effects on various aspects of the immune response mechanisms in humans. The purpose of this study was to evaluate the immunomodulatory potential of SE fruit infusion intake in healthy humans. Anthocyanin content was determined with UPLC-ESI-MS/MS. Fifty-three volunteers enrolled in a 4-week SE infusion intake intervention. Blood count, serum total protein, Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), Tumor Necrosis Factor Alpha (TNFα), High-sensitivity C-reactive protein (hs-CRP), C3, and C4 levels were measured on automatic analyzers, and Interleukin 8 (IL-8) was measured manually with an ELISA kit. Cyanidin-3-O-galactoside (48.15 mg/g DW), followed by cyaniding-3-sambubioside (43.41 ± 1.07 mg/g DW), were the most abundant anthocyanins in SE samples. A significant decrease in total protein (2.82%), IL-6 (20.15%), TNFα (5.38%), IL-8 (5.50%), C3 (4.16%), and C4 (14.29%) was established in the whole group. Total protein, IL-8, TNFα, and C4 decreased in women (3.11%, 4.76%, 5.09%, and 11.11%), and IL-6 decreased (40.61%) in men. Hb (1.20%) and hematocrit (1.55%) levels decreased in the whole group and in the women group (1.61% and 2.20%). SE fruits exert immune-modulatory activity as revealed by decreased pro-inflammatory status and complement activity markers in healthy volunteers after a 4-week intervention.</description><subject>Analyzers</subject><subject>Anthocyanins</subject><subject>Anthocyanins - analysis</subject><subject>C-reactive protein</subject><subject>Cell culture</subject><subject>Complement component C3</subject><subject>Complement component C4</subject><subject>Complement system</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Cyaniding</subject><subject>Cytokine storm</subject><subject>Cytotoxicity</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Female</subject><subject>Flavonoids</subject><subject>Folk medicine</subject><subject>Fruit - chemistry</subject><subject>Fruits</subject><subject>Galactosides</subject><subject>Gender</subject><subject>Hematocrit</subject><subject>Hematology</subject><subject>Herbal medicine</subject><subject>Herpes viruses</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunomodulation</subject><subject>Immunomodulators</subject><subject>Inflammation</subject><subject>Influenza</subject><subject>Interleukin 1</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Male</subject><subject>Medicine</subject><subject>Metabolites</subject><subject>Pandemics</subject><subject>Phytochemicals</subject><subject>Proteins</subject><subject>Rheumatoid arthritis</subject><subject>Sambucus</subject><subject>Sambucus ebulus</subject><subject>Serum proteins</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Tandem Mass Spectrometry</subject><subject>Tumor Necrosis Factor-alpha</subject><subject>Tumor necrosis factor-α</subject><subject>Viral infections</subject><subject>Womens 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ebulus (Elderberry) Fruits Modulate Inflammation and Complement System Activity in Humans</title><author>Kiselova-Kaneva, Yoana ; Nashar, Milka ; Roussev, Bogdan ; Salim, Ayshe ; Hristova, Minka ; Olczyk, Pawel ; Komosinska-Vassev, Katarzyna ; Dincheva, Ivayla ; Badjakov, Ilian ; Galunska, Bistra ; Ivanova, Diana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-55fac09137975a814555627b473acbd9d862e8b753a0432e3353daeb48496aad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analyzers</topic><topic>Anthocyanins</topic><topic>Anthocyanins - analysis</topic><topic>C-reactive protein</topic><topic>Cell culture</topic><topic>Complement component C3</topic><topic>Complement component C4</topic><topic>Complement system</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Cyaniding</topic><topic>Cytokine 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Currently, there is no scientific evidence of their effects on various aspects of the immune response mechanisms in humans. The purpose of this study was to evaluate the immunomodulatory potential of SE fruit infusion intake in healthy humans. Anthocyanin content was determined with UPLC-ESI-MS/MS. Fifty-three volunteers enrolled in a 4-week SE infusion intake intervention. Blood count, serum total protein, Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), Tumor Necrosis Factor Alpha (TNFα), High-sensitivity C-reactive protein (hs-CRP), C3, and C4 levels were measured on automatic analyzers, and Interleukin 8 (IL-8) was measured manually with an ELISA kit. Cyanidin-3-O-galactoside (48.15 mg/g DW), followed by cyaniding-3-sambubioside (43.41 ± 1.07 mg/g DW), were the most abundant anthocyanins in SE samples. A significant decrease in total protein (2.82%), IL-6 (20.15%), TNFα (5.38%), IL-8 (5.50%), C3 (4.16%), and C4 (14.29%) was established in the whole group. Total protein, IL-8, TNFα, and C4 decreased in women (3.11%, 4.76%, 5.09%, and 11.11%), and IL-6 decreased (40.61%) in men. Hb (1.20%) and hematocrit (1.55%) levels decreased in the whole group and in the women group (1.61% and 2.20%). SE fruits exert immune-modulatory activity as revealed by decreased pro-inflammatory status and complement activity markers in healthy volunteers after a 4-week intervention.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37240060</pmid><doi>10.3390/ijms24108714</doi><orcidid>https://orcid.org/0000-0001-9692-6227</orcidid><orcidid>https://orcid.org/0000-0003-0526-3996</orcidid><orcidid>https://orcid.org/0000-0001-7387-9587</orcidid><orcidid>https://orcid.org/0000-0003-2307-5884</orcidid><orcidid>https://orcid.org/0000-0002-1422-7121</orcidid><orcidid>https://orcid.org/0000-0003-0276-4170</orcidid><orcidid>https://orcid.org/0000-0003-3964-6039</orcidid><orcidid>https://orcid.org/0000-0002-4502-081X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2023-05, Vol.24 (10), p.8714 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Analyzers Anthocyanins Anthocyanins - analysis C-reactive protein Cell culture Complement component C3 Complement component C4 Complement system Coronaviruses COVID-19 Cyaniding Cytokine storm Cytotoxicity Enzyme-linked immunosorbent assay Female Flavonoids Folk medicine Fruit - chemistry Fruits Galactosides Gender Hematocrit Hematology Herbal medicine Herpes viruses Humans Immune response Immune system Immunomodulation Immunomodulators Inflammation Influenza Interleukin 1 Interleukin 6 Interleukin 8 Male Medicine Metabolites Pandemics Phytochemicals Proteins Rheumatoid arthritis Sambucus Sambucus ebulus Serum proteins Severe acute respiratory syndrome coronavirus 2 Tandem Mass Spectrometry Tumor Necrosis Factor-alpha Tumor necrosis factor-α Viral infections Womens health |
| title | Sambucus ebulus (Elderberry) Fruits Modulate Inflammation and Complement System Activity in Humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T10%3A23%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sambucus%20ebulus%20(Elderberry)%20Fruits%20Modulate%20Inflammation%20and%20Complement%20System%20Activity%20in%20Humans&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Kiselova-Kaneva,%20Yoana&rft.date=2023-05-13&rft.volume=24&rft.issue=10&rft.spage=8714&rft.pages=8714-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms24108714&rft_dat=%3Cproquest_pubme%3E2819432906%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2819432906&rft_id=info:pmid/37240060&rfr_iscdi=true |