The Impact of Tumor Cell-Intrinsic Expression of Cyclic GMP-AMP Synthase (cGAS)-Stimulator of Interferon Genes (STING) on the Infiltration of CD8 + T Cells and Clinical Outcomes in Mismatch Repair Proficient/Microsatellite Stable Colorectal Cancer

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a crucial role in activating immune cells in the tumor microenvironment, thereby contributing to a more favorable response to immune checkpoint inhibitors (ICI) in colorectal cancer (CRC). However, the impact of...

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Veröffentlicht in:	Cancers 2023-05, Vol.15 (10), p.2826
Hauptverfasser:	Nakajima, Shotaro, Kaneta, Akinao, Okayama, Hirokazu, Saito, Katsuharu, Kikuchi, Tomohiro, Endo, Eisei, Matsumoto, Takuro, Fukai, Satoshi, Sakuma, Mei, Sato, Takahiro, Mimura, Kosaku, Saito, Motonobu, Saze, Zenichiro, Sakamoto, Wataru, Onozawa, Hisashi, Momma, Tomoyuki, Kono, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP Antibodies Cancer CD4 antigen CD8 antigen Clinical outcomes Colorectal cancer Colorectal carcinoma Cyclic GMP Cytoplasm Gene expression Histones Immune checkpoint inhibitors Infiltration Interferon Ligands Lymphocytes Lymphocytes T Metastases Methylation Mismatch repair Patients Tumor cells Tumor microenvironment Tumors Yeast
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