CD103 + regulatory T cells underlie resistance to radio-immunotherapy and impair CD8 + T cell activation in glioblastoma

Glioblastomas are aggressive primary brain tumors with an inherent resistance to T cell-centric immunotherapy due to their low mutational burden and immunosuppressive tumor microenvironment. Here we report that fractionated radiotherapy of preclinical glioblastoma models induce a tenfold increase in...

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Veröffentlicht in:	Nature cancer 2023-05, Vol.4 (5), p.665-681
Hauptverfasser:	van Hooren, Luuk, Handgraaf, Shanna M, Kloosterman, Daan J, Karimi, Elham, van Mil, Lotte W H G, Gassama, Awa A, Solsona, Beatriz Gomez, de Groot, Marnix H P, Brandsma, Dieta, Quail, Daniela F, Walsh, Logan A, Borst, Gerben R, Akkari, Leila
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8-Positive T-Lymphocytes Glioblastoma - radiotherapy Humans Immunotherapy - methods Mice Neoplasm Recurrence, Local - metabolism Programmed Cell Death 1 Receptor - metabolism Programmed Cell Death 1 Receptor - therapeutic use T-Lymphocytes, Regulatory - metabolism Tumor Microenvironment
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