Characterization of prostanoids response to Bordetella pertussis antigen BscF and Tdap in LPS-challenged monocytes

•These results are the first to demonstrate a regulatory role for BscF and Tdap in prostanoids production.•BscF, alone elicit immunomodulatory effect comparable to three pertussis antigens (PT, FHA, FIM) present in Tdap vaccine.•BscF have the potential to be used as a adjuvant for a next-generation...

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Veröffentlicht in:	Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2022-07, Vol.182, p.102452-102452, Article 102452
Hauptverfasser:	Raihan, Md.Obayed, Espelien, Brenna M., Hanson, Courtney, McGregor, Brett A., Velaris, Nathan A., Alvine, Travis D., Al. Golovko, Svetlana, Bradley, David S., Nilles, Matthew, Glovko, Mikhail Y., Hur, Junguk, Porter, James E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Bacterial Antigens, Bacterial Bordetella pertussis Diphtheria-Tetanus-acellular Pertussis Vaccines Humans Lipids Lipopolysaccharides - pharmacology Monocytes Prostacyclin Prostaglandin Prostaglandins Prostanoid Vaccine Whooping Cough - prevention & control
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