Phylogenetic Comparative Analysis of Single-Cell Transcriptomes Reveals Constrained Accumulation of Gene Expression Heterogeneity during Clonal Expansion

Abstract In the same way that a phylogeny summarizes the evolutionary history of species, a cell lineage tree describes the process of clonal expansion, in which gene expression differences between cells naturally accrue as a result of stochastic partitioning and imperfect expression control. How is...

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Veröffentlicht in:	Molecular biology and evolution 2023-05, Vol.40 (5)
Hauptverfasser:	Chen, Feng, Li, Zizhang, Zhang, Xiaoyu, Wu, Peng, Yang, Wenjing, Yang, Junnan, Chen, Xiaoshu, Yang, Jian-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological Evolution Discoveries Gene expression Gene Expression Profiling Genes Genetic research HEK293 Cells Humans Phylogeny Transcriptome
Online-Zugang:	Volltext
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