Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches
We aimed to investigate the joint, class-specific, and individual impacts of (i) PFAS, (ii) toxic metals and metalloids (referred to collectively as “metals”), and (iii) essential elements on birth outcomes in a prospective pregnancy cohort using both established and recent mixture modeling approach...
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Veröffentlicht in: | Chemosphere (Oxford) 2023-07, Vol.329, p.138644-138644, Article 138644 |
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creator | Yim, Gyeyoon McGee, Glen Gallagher, Lisa Baker, Emily Jackson, Brian P. Calafat, Antonia M. Botelho, Julianne Cook Gilbert-Diamond, Diane Karagas, Margaret R. Romano, Megan E. Howe, Caitlin G. |
description | We aimed to investigate the joint, class-specific, and individual impacts of (i) PFAS, (ii) toxic metals and metalloids (referred to collectively as “metals”), and (iii) essential elements on birth outcomes in a prospective pregnancy cohort using both established and recent mixture modeling approaches. Participants included 537 mother-child pairs from the New Hampshire Birth Cohort Study. Concentrations of 6 metals and 5 PFAS were measured in maternal toenail clippings and plasma, respectively. Birth weight, birth length, and head circumference at birth were abstracted from medical records. Joint, index-wise, and individual associations of the metals and PFAS concentrations with birth outcomes were evaluated using Bayesian Kernel Machine Regression (BKMR) and Bayesian Multiple Index Models (BMIM). After controlling for potential confounders, the metals-PFAS mixture was associated with a larger head circumference at birth, which was driven by manganese. When using BKMR, the difference in the head circumference z-score when changing manganese from its 25th to 75th percentiles while holding all other mixture components at their medians was 0.22 standard deviations (95% posterior credible interval [CI]: −0.02, 0.46). When using BMIM, the posterior mean of index weight estimates assigned to manganese for head circumference z-score was 0.72 (95% CI: 0, 0.99). Prenatal exposure to the metals-PFAS mixture was not associated with birth weight or birth length by either BKMR or BMIM. Using both traditional and new mixture modeling approaches, prenatal exposure to manganese was associated with a larger head circumference at birth after accounting for exposure to PFAS and multiple toxic and essential metals.
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•The essential element class was associated with higher HC.•Mn was the main contributor to the higher HC, accounting for other chemicals.•The positive Mn-HC relationship was driven by male infants.•No class-wise interactions were identified using Bayesian Multiple Index Models. |
doi_str_mv | 10.1016/j.chemosphere.2023.138644 |
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•The essential element class was associated with higher HC.•Mn was the main contributor to the higher HC, accounting for other chemicals.•The positive Mn-HC relationship was driven by male infants.•No class-wise interactions were identified using Bayesian Multiple Index Models.</description><identifier>ISSN: 0045-6535</identifier><identifier>ISSN: 1879-1298</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2023.138644</identifier><identifier>PMID: 37031836</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alkanesulfonic Acids ; Bayes Theorem ; Bayesian multiple index model (BMIM) ; Birth outcomes ; Birth Weight ; Cohort Studies ; Environmental mixtures ; Environmental Pollutants - toxicity ; Essential elements ; Female ; Fluorocarbons - toxicity ; Humans ; Infant, Newborn ; Manganese ; Metals ; New Hampshire ; Per- and polyfluoroalkyl substances (PFAS) ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prospective Studies ; Toxic metals</subject><ispartof>Chemosphere (Oxford), 2023-07, Vol.329, p.138644-138644, Article 138644</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-f20bb363c19099565d91463f16b64ac540ce43b72bd097c0fc745c9817a1c50d3</citedby><cites>FETCH-LOGICAL-c433t-f20bb363c19099565d91463f16b64ac540ce43b72bd097c0fc745c9817a1c50d3</cites><orcidid>0000-0002-8923-9485</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2023.138644$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37031836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yim, Gyeyoon</creatorcontrib><creatorcontrib>McGee, Glen</creatorcontrib><creatorcontrib>Gallagher, Lisa</creatorcontrib><creatorcontrib>Baker, Emily</creatorcontrib><creatorcontrib>Jackson, Brian P.</creatorcontrib><creatorcontrib>Calafat, Antonia M.</creatorcontrib><creatorcontrib>Botelho, Julianne Cook</creatorcontrib><creatorcontrib>Gilbert-Diamond, Diane</creatorcontrib><creatorcontrib>Karagas, Margaret R.</creatorcontrib><creatorcontrib>Romano, Megan E.</creatorcontrib><creatorcontrib>Howe, Caitlin G.</creatorcontrib><title>Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>We aimed to investigate the joint, class-specific, and individual impacts of (i) PFAS, (ii) toxic metals and metalloids (referred to collectively as “metals”), and (iii) essential elements on birth outcomes in a prospective pregnancy cohort using both established and recent mixture modeling approaches. Participants included 537 mother-child pairs from the New Hampshire Birth Cohort Study. Concentrations of 6 metals and 5 PFAS were measured in maternal toenail clippings and plasma, respectively. Birth weight, birth length, and head circumference at birth were abstracted from medical records. Joint, index-wise, and individual associations of the metals and PFAS concentrations with birth outcomes were evaluated using Bayesian Kernel Machine Regression (BKMR) and Bayesian Multiple Index Models (BMIM). After controlling for potential confounders, the metals-PFAS mixture was associated with a larger head circumference at birth, which was driven by manganese. When using BKMR, the difference in the head circumference z-score when changing manganese from its 25th to 75th percentiles while holding all other mixture components at their medians was 0.22 standard deviations (95% posterior credible interval [CI]: −0.02, 0.46). When using BMIM, the posterior mean of index weight estimates assigned to manganese for head circumference z-score was 0.72 (95% CI: 0, 0.99). Prenatal exposure to the metals-PFAS mixture was not associated with birth weight or birth length by either BKMR or BMIM. Using both traditional and new mixture modeling approaches, prenatal exposure to manganese was associated with a larger head circumference at birth after accounting for exposure to PFAS and multiple toxic and essential metals.
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•The essential element class was associated with higher HC.•Mn was the main contributor to the higher HC, accounting for other chemicals.•The positive Mn-HC relationship was driven by male infants.•No class-wise interactions were identified using Bayesian Multiple Index Models.</description><subject>Alkanesulfonic Acids</subject><subject>Bayes Theorem</subject><subject>Bayesian multiple index model (BMIM)</subject><subject>Birth outcomes</subject><subject>Birth Weight</subject><subject>Cohort Studies</subject><subject>Environmental mixtures</subject><subject>Environmental Pollutants - toxicity</subject><subject>Essential elements</subject><subject>Female</subject><subject>Fluorocarbons - toxicity</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Manganese</subject><subject>Metals</subject><subject>New Hampshire</subject><subject>Per- and polyfluoroalkyl substances (PFAS)</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prospective Studies</subject><subject>Toxic metals</subject><issn>0045-6535</issn><issn>1879-1298</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1z1CAYxxlHx26rX8HBm5esvCQkeHHsjrbOVD2oZ4aQJw0rCRFIdb-Kn1Zq6k69eYKB_8sDP4SeU7KlhIqX-60ZYPRxHiDAlhHGt5Q3oiwfoA1tallQJpuHaENIWRWi4tUJOo1xT0g2V_IxOuE14bThYoN-fYCkXcR66vAMoVg33h16t_jgtft2cDgubUx6MhDxaH-mJcBqaG1IA_ZLMn7MR3bCaQD8EX7gSz3OcbAB8Pkfzc4PPiT8OS3d4RU-h4PP9minaweFcToeg7Ge51yb3xefoEd9Hg2e3q1n6Ou7t192l8XVp4v3uzdXhSk5T0XPSNtywQ2VRMpKVJ2kpeA9Fa0otalKYqDkbc3ajsjakN7UZWVkQ2tNTUU6foZer7nz0o7QGZhS0E7NwY46HJTXVv17M9lBXfsbRQkjDaMiJ7y4Swj--wIxqdFGA87pCfwSFaulpDVjgmSpXKUm-BgD9MceStQtXLVX9-CqW7hqhZu9z-4PenT-pZkFu1UA-btuLAQVjYXMrcskTFKdt_9R8xuLb8An</recordid><startdate>20230701</startdate><enddate>20230701</enddate><creator>Yim, Gyeyoon</creator><creator>McGee, Glen</creator><creator>Gallagher, Lisa</creator><creator>Baker, Emily</creator><creator>Jackson, Brian P.</creator><creator>Calafat, Antonia M.</creator><creator>Botelho, Julianne Cook</creator><creator>Gilbert-Diamond, Diane</creator><creator>Karagas, Margaret R.</creator><creator>Romano, Megan E.</creator><creator>Howe, Caitlin G.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8923-9485</orcidid></search><sort><creationdate>20230701</creationdate><title>Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches</title><author>Yim, Gyeyoon ; McGee, Glen ; Gallagher, Lisa ; Baker, Emily ; Jackson, Brian P. ; Calafat, Antonia M. ; Botelho, Julianne Cook ; Gilbert-Diamond, Diane ; Karagas, Margaret R. ; Romano, Megan E. ; Howe, Caitlin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-f20bb363c19099565d91463f16b64ac540ce43b72bd097c0fc745c9817a1c50d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alkanesulfonic Acids</topic><topic>Bayes Theorem</topic><topic>Bayesian multiple index model (BMIM)</topic><topic>Birth outcomes</topic><topic>Birth Weight</topic><topic>Cohort Studies</topic><topic>Environmental mixtures</topic><topic>Environmental Pollutants - toxicity</topic><topic>Essential elements</topic><topic>Female</topic><topic>Fluorocarbons - toxicity</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Manganese</topic><topic>Metals</topic><topic>New Hampshire</topic><topic>Per- and polyfluoroalkyl substances (PFAS)</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prospective Studies</topic><topic>Toxic metals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yim, Gyeyoon</creatorcontrib><creatorcontrib>McGee, Glen</creatorcontrib><creatorcontrib>Gallagher, Lisa</creatorcontrib><creatorcontrib>Baker, Emily</creatorcontrib><creatorcontrib>Jackson, Brian P.</creatorcontrib><creatorcontrib>Calafat, Antonia M.</creatorcontrib><creatorcontrib>Botelho, Julianne Cook</creatorcontrib><creatorcontrib>Gilbert-Diamond, Diane</creatorcontrib><creatorcontrib>Karagas, Margaret R.</creatorcontrib><creatorcontrib>Romano, Megan E.</creatorcontrib><creatorcontrib>Howe, Caitlin G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yim, Gyeyoon</au><au>McGee, Glen</au><au>Gallagher, Lisa</au><au>Baker, Emily</au><au>Jackson, Brian P.</au><au>Calafat, Antonia M.</au><au>Botelho, Julianne Cook</au><au>Gilbert-Diamond, Diane</au><au>Karagas, Margaret R.</au><au>Romano, Megan E.</au><au>Howe, Caitlin G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2023-07-01</date><risdate>2023</risdate><volume>329</volume><spage>138644</spage><epage>138644</epage><pages>138644-138644</pages><artnum>138644</artnum><issn>0045-6535</issn><issn>1879-1298</issn><eissn>1879-1298</eissn><abstract>We aimed to investigate the joint, class-specific, and individual impacts of (i) PFAS, (ii) toxic metals and metalloids (referred to collectively as “metals”), and (iii) essential elements on birth outcomes in a prospective pregnancy cohort using both established and recent mixture modeling approaches. Participants included 537 mother-child pairs from the New Hampshire Birth Cohort Study. Concentrations of 6 metals and 5 PFAS were measured in maternal toenail clippings and plasma, respectively. Birth weight, birth length, and head circumference at birth were abstracted from medical records. Joint, index-wise, and individual associations of the metals and PFAS concentrations with birth outcomes were evaluated using Bayesian Kernel Machine Regression (BKMR) and Bayesian Multiple Index Models (BMIM). After controlling for potential confounders, the metals-PFAS mixture was associated with a larger head circumference at birth, which was driven by manganese. When using BKMR, the difference in the head circumference z-score when changing manganese from its 25th to 75th percentiles while holding all other mixture components at their medians was 0.22 standard deviations (95% posterior credible interval [CI]: −0.02, 0.46). When using BMIM, the posterior mean of index weight estimates assigned to manganese for head circumference z-score was 0.72 (95% CI: 0, 0.99). Prenatal exposure to the metals-PFAS mixture was not associated with birth weight or birth length by either BKMR or BMIM. Using both traditional and new mixture modeling approaches, prenatal exposure to manganese was associated with a larger head circumference at birth after accounting for exposure to PFAS and multiple toxic and essential metals.
[Display omitted]
•The essential element class was associated with higher HC.•Mn was the main contributor to the higher HC, accounting for other chemicals.•The positive Mn-HC relationship was driven by male infants.•No class-wise interactions were identified using Bayesian Multiple Index Models.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>37031836</pmid><doi>10.1016/j.chemosphere.2023.138644</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-8923-9485</orcidid></addata></record> |
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subjects | Alkanesulfonic Acids Bayes Theorem Bayesian multiple index model (BMIM) Birth outcomes Birth Weight Cohort Studies Environmental mixtures Environmental Pollutants - toxicity Essential elements Female Fluorocarbons - toxicity Humans Infant, Newborn Manganese Metals New Hampshire Per- and polyfluoroalkyl substances (PFAS) Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Toxic metals |
title | Metals and per- and polyfluoroalkyl substances mixtures and birth outcomes in the New Hampshire Birth Cohort Study: Beyond single-class mixture approaches |
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