CryoEM Structure with ATP Synthase Enables Late‐Stage Diversification of Cruentaren A

Cruentaren A is a natural product that exhibits potent antiproliferative activity against various cancer cell lines, yet its binding site within ATP synthase remained unknown, thus limiting the development of improved analogues as anticancer agents. Herein, we report the cryogenic electron microscop...

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Veröffentlicht in:	Chemistry : a European journal 2023-05, Vol.29 (29), p.e202300262-n/a
Hauptverfasser:	Dou, Xiaozheng, Guo, Hui, D'Amico, Terin, Abdallah, Leah, Subramanian, Chitra, Patel, Bhargav A., Cohen, Mark, Rubinstein, John L., Blagg, Brian S. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor agents ATP synthase Binding sites Cancer Cell Line Chemistry cruentaren A Cryoelectron Microscopy cryoEM structure Electron microscopy Humans late-stage modification Molecular Structure natural product Natural products Neoplasms Structure-Activity Relationship Tumor cell lines
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