Cardio-Protective Role of a Gut Hormone Obestatin: A Narrative Review
Obestatin is a gut hormone composed of 23 amino acids that play a role in protecting the heart. It is synthesized from the same preproghrelin gut hormone gene as another gut hormone. The function and receptor of obestatin remain controversial, despite being present in various organs such as the live...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-04, Vol.15 (4), p.e37972-e37972 |
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| creator | Bora, Rajal R Prasad, Roshan Khatib, Mahalaqua Nazli |
| description | Obestatin is a gut hormone composed of 23 amino acids that play a role in protecting the heart. It is synthesized from the same preproghrelin gut hormone gene as another gut hormone. The function and receptor of obestatin remain controversial, despite being present in various organs such as the liver, heart, mammary gland, pancreas, and more. The activity of obestatin is opposite to that of ghrelin, another hormone. The GPR-39 receptor is used by obestatin to exert its effects. Obestatin's cardioprotective role can be attributed to its ability to affect various factors, including adipose tissue, blood pressure regulation, heart, ischemia-reperfusion injury, endothelial cells, and diabetes. Because these factors are related to the cardiovascular system, modifying them via obestatin can provide cardioprotection. Furthermore, ghrelin, its antagonist hormone, regulates cardiovascular health. Diabetes mellitus, hypertension, and ischemia-reperfusion injury can all alter ghrelin/obestatin levels. Obestatin has also been shown to impact other organs, reducing weight and appetite, inhibiting food intake, and increasing adipogenesis. Obestatin has a brief half-life and is quickly degraded by proteases in the blood, liver, and kidneys after entering circulation. This article offers insights into the cardiac function of obestatin. |
| doi_str_mv | 10.7759/cureus.37972 |
| format | Article |
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It is synthesized from the same preproghrelin gut hormone gene as another gut hormone. The function and receptor of obestatin remain controversial, despite being present in various organs such as the liver, heart, mammary gland, pancreas, and more. The activity of obestatin is opposite to that of ghrelin, another hormone. The GPR-39 receptor is used by obestatin to exert its effects. Obestatin's cardioprotective role can be attributed to its ability to affect various factors, including adipose tissue, blood pressure regulation, heart, ischemia-reperfusion injury, endothelial cells, and diabetes. Because these factors are related to the cardiovascular system, modifying them via obestatin can provide cardioprotection. Furthermore, ghrelin, its antagonist hormone, regulates cardiovascular health. Diabetes mellitus, hypertension, and ischemia-reperfusion injury can all alter ghrelin/obestatin levels. Obestatin has also been shown to impact other organs, reducing weight and appetite, inhibiting food intake, and increasing adipogenesis. Obestatin has a brief half-life and is quickly degraded by proteases in the blood, liver, and kidneys after entering circulation. This article offers insights into the cardiac function of obestatin.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.37972</identifier><identifier>PMID: 37223200</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Adipocytes ; Apoptosis ; Atherosclerosis ; Biomarkers ; Blood pressure ; Brain research ; Cardiovascular system ; Diabetes ; Food ; Glucose ; Growth hormones ; Heart ; Insulin resistance ; Ischemia ; Kinases ; Medical Education ; Metabolism ; Motility ; Nervous system ; Pancreas ; Pancreatitis ; Peptides ; Physiology</subject><ispartof>Curēus (Palo Alto, CA), 2023-04, Vol.15 (4), p.e37972-e37972</ispartof><rights>Copyright © 2023, Bora et al.</rights><rights>Copyright © 2023, Bora et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Bora et al. 2023 Bora et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c343t-a31e31be9ac97b74e4f5176aa07bb78ddd0eee95d570c0eaea31a2ca653f71d43</citedby><cites>FETCH-LOGICAL-c343t-a31e31be9ac97b74e4f5176aa07bb78ddd0eee95d570c0eaea31a2ca653f71d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202687/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202687/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37223200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bora, Rajal R</creatorcontrib><creatorcontrib>Prasad, Roshan</creatorcontrib><creatorcontrib>Khatib, Mahalaqua Nazli</creatorcontrib><title>Cardio-Protective Role of a Gut Hormone Obestatin: A Narrative Review</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Obestatin is a gut hormone composed of 23 amino acids that play a role in protecting the heart. It is synthesized from the same preproghrelin gut hormone gene as another gut hormone. The function and receptor of obestatin remain controversial, despite being present in various organs such as the liver, heart, mammary gland, pancreas, and more. The activity of obestatin is opposite to that of ghrelin, another hormone. The GPR-39 receptor is used by obestatin to exert its effects. Obestatin's cardioprotective role can be attributed to its ability to affect various factors, including adipose tissue, blood pressure regulation, heart, ischemia-reperfusion injury, endothelial cells, and diabetes. Because these factors are related to the cardiovascular system, modifying them via obestatin can provide cardioprotection. Furthermore, ghrelin, its antagonist hormone, regulates cardiovascular health. Diabetes mellitus, hypertension, and ischemia-reperfusion injury can all alter ghrelin/obestatin levels. Obestatin has also been shown to impact other organs, reducing weight and appetite, inhibiting food intake, and increasing adipogenesis. Obestatin has a brief half-life and is quickly degraded by proteases in the blood, liver, and kidneys after entering circulation. This article offers insights into the cardiac function of obestatin.</description><subject>Adipocytes</subject><subject>Apoptosis</subject><subject>Atherosclerosis</subject><subject>Biomarkers</subject><subject>Blood pressure</subject><subject>Brain research</subject><subject>Cardiovascular system</subject><subject>Diabetes</subject><subject>Food</subject><subject>Glucose</subject><subject>Growth hormones</subject><subject>Heart</subject><subject>Insulin resistance</subject><subject>Ischemia</subject><subject>Kinases</subject><subject>Medical Education</subject><subject>Metabolism</subject><subject>Motility</subject><subject>Nervous system</subject><subject>Pancreas</subject><subject>Pancreatitis</subject><subject>Peptides</subject><subject>Physiology</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkc1Lw0AQxRdRtFRvniXgxYOp-5FkEi9SSm0FsSJ6XiabiUbSbN1NKv73RquinnZgf_Nm3jzGDgUfAcTZmekcdX6kIAO5xQZSJGmYijTa_lXvsQPvnznngoPkwHfZngIpleR8wKYTdEVlw1tnWzJttabgztYU2DLAYNa1wdy6pW0oWOTkW2yr5jwYBzfoHG5gWlf0us92Sqw9HXy9Q_ZwOb2fzMPrxexqMr4OjYpUG6ISpEROGZoMcogoKmMBCSKHPIe0KApORFlcxMANJ6S-AaXBJFYliCJSQ3ax0V11-ZIKQ03rsNYrVy3RvWmLlf7701RP-tGuteCSyySFXuHkS8HZl663pJeVN1TX2JDtvJb9xSCKk37kkB3_Q59t55reX09JIUEp-KBON5Rx1ntH5c82guuPjPQmI_2ZUY8f_XbwA38not4BrMSN9A</recordid><startdate>20230422</startdate><enddate>20230422</enddate><creator>Bora, Rajal R</creator><creator>Prasad, Roshan</creator><creator>Khatib, Mahalaqua Nazli</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230422</creationdate><title>Cardio-Protective Role of a Gut Hormone Obestatin: A Narrative Review</title><author>Bora, Rajal R ; Prasad, Roshan ; Khatib, Mahalaqua Nazli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-a31e31be9ac97b74e4f5176aa07bb78ddd0eee95d570c0eaea31a2ca653f71d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adipocytes</topic><topic>Apoptosis</topic><topic>Atherosclerosis</topic><topic>Biomarkers</topic><topic>Blood pressure</topic><topic>Brain research</topic><topic>Cardiovascular system</topic><topic>Diabetes</topic><topic>Food</topic><topic>Glucose</topic><topic>Growth hormones</topic><topic>Heart</topic><topic>Insulin resistance</topic><topic>Ischemia</topic><topic>Kinases</topic><topic>Medical Education</topic><topic>Metabolism</topic><topic>Motility</topic><topic>Nervous system</topic><topic>Pancreas</topic><topic>Pancreatitis</topic><topic>Peptides</topic><topic>Physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bora, Rajal R</creatorcontrib><creatorcontrib>Prasad, Roshan</creatorcontrib><creatorcontrib>Khatib, Mahalaqua Nazli</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bora, Rajal R</au><au>Prasad, Roshan</au><au>Khatib, Mahalaqua Nazli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardio-Protective Role of a Gut Hormone Obestatin: A Narrative Review</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2023-04-22</date><risdate>2023</risdate><volume>15</volume><issue>4</issue><spage>e37972</spage><epage>e37972</epage><pages>e37972-e37972</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Obestatin is a gut hormone composed of 23 amino acids that play a role in protecting the heart. It is synthesized from the same preproghrelin gut hormone gene as another gut hormone. The function and receptor of obestatin remain controversial, despite being present in various organs such as the liver, heart, mammary gland, pancreas, and more. The activity of obestatin is opposite to that of ghrelin, another hormone. The GPR-39 receptor is used by obestatin to exert its effects. Obestatin's cardioprotective role can be attributed to its ability to affect various factors, including adipose tissue, blood pressure regulation, heart, ischemia-reperfusion injury, endothelial cells, and diabetes. Because these factors are related to the cardiovascular system, modifying them via obestatin can provide cardioprotection. Furthermore, ghrelin, its antagonist hormone, regulates cardiovascular health. Diabetes mellitus, hypertension, and ischemia-reperfusion injury can all alter ghrelin/obestatin levels. Obestatin has also been shown to impact other organs, reducing weight and appetite, inhibiting food intake, and increasing adipogenesis. Obestatin has a brief half-life and is quickly degraded by proteases in the blood, liver, and kidneys after entering circulation. This article offers insights into the cardiac function of obestatin.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>37223200</pmid><doi>10.7759/cureus.37972</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Apoptosis Atherosclerosis Biomarkers Blood pressure Brain research Cardiovascular system Diabetes Food Glucose Growth hormones Heart Insulin resistance Ischemia Kinases Medical Education Metabolism Motility Nervous system Pancreas Pancreatitis Peptides Physiology |
| title | Cardio-Protective Role of a Gut Hormone Obestatin: A Narrative Review |
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