A family-wide assessment of latent STAT transcription factor interactions reveals divergent dimer repertoires

The conversion of signal transducer and activator of transcription (STAT) proteins from latent to active transcription factors is central to cytokine signaling. Triggered by their signal-induced tyrosine phosphorylation, it is the assembly of a range of cytokine-specific STAT homo- and heterodimers...

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Veröffentlicht in:	The Journal of biological chemistry 2023-05, Vol.299 (5), p.104703-104703, Article 104703
Hauptverfasser:	Begitt, Andreas, Krause, Sebastian, Cavey, James R., Vinkemeier, Doratha E., Vinkemeier, Uwe
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytokines - metabolism dimerization Gene Expression Regulation heterodimer homodimer interaction assay JBC Communication nuclear export signal nuclear import signal Phosphorylation STAT1 STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism STAT2 STAT2 Transcription Factor - metabolism STAT3 STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism STAT4 STAT4 Transcription Factor STAT5 Transcription Factor - genetics STAT5 Transcription Factor - metabolism STAT5A STAT5B STAT6 Trans-Activators - metabolism transcription factor
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