Mechanisms of N6‑methyladenosine modification in tumor development and potential therapeutic strategies (Review)
N6‑methyladenosine (m6A) modification, as the most common and abundant type of RNA modification in mammalian cells, participates in the processes of mRNA transcription, translation, splicing and degradation, serving to regulate RNA stability. In recent years, a large number of studies have indicated...
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| Veröffentlicht in: | International journal of oncology 2023-06, Vol.62 (6), p.1, Article 75 |
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| container_title | International journal of oncology |
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| creator | Pu, Xi Wu, Yuting Ji, Qian Fu, Shengqiao Zuo, Hao Chu, Liangmei Tang, Haowen Wan, Mengtian Wang, Xu Xu, Min |
| description | N6‑methyladenosine (m6A) modification, as the most common and abundant type of RNA modification in mammalian cells, participates in the processes of mRNA transcription, translation, splicing and degradation, serving to regulate RNA stability. In recent years, a large number of studies have indicated that m6A modification is able to affect tumor progression, participate in tumor metabolism, regulate tumor cell ferroptosis and change the tumor immune microenvironment, thereby affecting tumor immunotherapy. In the current review, the main features of m6A‑associated proteins are presented with a focus on the mechanisms underpinning their roles in tumor progression, metabolism, ferroptosis and immunotherapy, also emphasizing the potential of targeting m6A‑associated proteins as a promising strategy for the treatment of cancer. |
| doi_str_mv | 10.3892/ijo.2023.5523 |
| format | Article |
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In recent years, a large number of studies have indicated that m6A modification is able to affect tumor progression, participate in tumor metabolism, regulate tumor cell ferroptosis and change the tumor immune microenvironment, thereby affecting tumor immunotherapy. In the current review, the main features of m6A‑associated proteins are presented with a focus on the mechanisms underpinning their roles in tumor progression, metabolism, ferroptosis and immunotherapy, also emphasizing the potential of targeting m6A‑associated proteins as a promising strategy for the treatment of cancer.</description><identifier>ISSN: 1019-6439</identifier><identifier>EISSN: 1791-2423</identifier><identifier>DOI: 10.3892/ijo.2023.5523</identifier><identifier>PMID: 37203412</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Adenosine ; Analysis ; Animals ; Bladder cancer ; Cancer ; Cells ; Development and progression ; Ferroptosis ; Gastric cancer ; Genetic transcription ; Genetic translation ; Health aspects ; Humans ; Immunotherapy ; Mammals ; Medical research ; Metabolism ; Metastasis ; Methyltransferases ; Neoplasms - genetics ; Neoplasms - therapy ; Obesity ; Physiological aspects ; Proteins ; RNA ; Tumor Microenvironment - genetics ; Tumors</subject><ispartof>International journal of oncology, 2023-06, Vol.62 (6), p.1, Article 75</ispartof><rights>COPYRIGHT 2023 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2023</rights><rights>Copyright: © Pu et al. 2023</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-c042c1ba7e791cba26c7105f25d2e162c6f9e6b2f95d4ecb44596176902d758a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37203412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pu, Xi</creatorcontrib><creatorcontrib>Wu, Yuting</creatorcontrib><creatorcontrib>Ji, Qian</creatorcontrib><creatorcontrib>Fu, Shengqiao</creatorcontrib><creatorcontrib>Zuo, Hao</creatorcontrib><creatorcontrib>Chu, Liangmei</creatorcontrib><creatorcontrib>Tang, Haowen</creatorcontrib><creatorcontrib>Wan, Mengtian</creatorcontrib><creatorcontrib>Wang, Xu</creatorcontrib><creatorcontrib>Xu, Min</creatorcontrib><title>Mechanisms of N6‑methyladenosine modification in tumor development and potential therapeutic strategies (Review)</title><title>International journal of oncology</title><addtitle>Int J Oncol</addtitle><description>N6‑methyladenosine (m6A) modification, as the most common and abundant type of RNA modification in mammalian cells, participates in the processes of mRNA transcription, translation, splicing and degradation, serving to regulate RNA stability. 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In the current review, the main features of m6A‑associated proteins are presented with a focus on the mechanisms underpinning their roles in tumor progression, metabolism, ferroptosis and immunotherapy, also emphasizing the potential of targeting m6A‑associated proteins as a promising strategy for the treatment of cancer.</description><subject>Adenosine</subject><subject>Analysis</subject><subject>Animals</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Cells</subject><subject>Development and progression</subject><subject>Ferroptosis</subject><subject>Gastric cancer</subject><subject>Genetic transcription</subject><subject>Genetic translation</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Mammals</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Metastasis</subject><subject>Methyltransferases</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - therapy</subject><subject>Obesity</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>RNA</subject><subject>Tumor Microenvironment - genetics</subject><subject>Tumors</subject><issn>1019-6439</issn><issn>1791-2423</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptks-K1TAUxosozji6dCsBQXTRa_40TbOSYXBUGBVE1yFNT29zaZOapFdmN6_gK_okpsx4mQuSRQ7J73w55-QriucEb1gj6Vu78xuKKdtwTtmD4pQISUpaUfYwx5jIsq6YPCmexLjDmHKOyePihAmKWUXoaRE-gxm0s3GKyPfoS_3n5vcEabgedQfOR-sATb6zvTU6We-QdSgtkw-ogz2Mfp7AJaRdh2afcmj1iNIAQc-wJGtQTEEn2FqI6PU32Fv49eZp8ajXY4Rnd_tZ8ePy_feLj-XV1w-fLs6vSsNJlUqDK2pIqwXkjkyraW0EwbynvKNAamrqXkLd0l7yrgLTVhWXNRG1xLQTvNHsrHh3qzsv7QSdydUFPao52EmHa-W1Vcc3zg5q6_dqHVuT38oKL-8Ugv-5QExq55fgctGKNkRKges86AO11SMo63qf1cxko1HnglMhcNWwTG3-Q-XVwWSNd9DbfH6U8OpewgB6TEP047L-QjwGy1vQBB9jgP7QIsFq9YjKHlGrR9Tqkcy_uD-XA_3PFOwvNFG4-A</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Pu, Xi</creator><creator>Wu, Yuting</creator><creator>Ji, Qian</creator><creator>Fu, Shengqiao</creator><creator>Zuo, Hao</creator><creator>Chu, Liangmei</creator><creator>Tang, Haowen</creator><creator>Wan, Mengtian</creator><creator>Wang, Xu</creator><creator>Xu, Min</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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| subjects | Adenosine Analysis Animals Bladder cancer Cancer Cells Development and progression Ferroptosis Gastric cancer Genetic transcription Genetic translation Health aspects Humans Immunotherapy Mammals Medical research Metabolism Metastasis Methyltransferases Neoplasms - genetics Neoplasms - therapy Obesity Physiological aspects Proteins RNA Tumor Microenvironment - genetics Tumors |
| title | Mechanisms of N6‑methyladenosine modification in tumor development and potential therapeutic strategies (Review) |
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