Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort
Purpose We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates. Methods Using baseline in...
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| Veröffentlicht in: | European journal of nutrition 2023-06, Vol.62 (4), p.1667-1680 |
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| creator | Talavera-Rodriguez, Irene Fernandez-Lazaro, Cesar I. Hernández-Ruiz, Ángela Hershey, Maria S. Galarregui, Cristina Sotos-Prieto, Mercedes de la Fuente-Arrillaga, Carmen Martínez-González, Miguel Ángel Ruiz-Canela, Miguel |
| description | Purpose
We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates.
Methods
Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures—vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index, alcohol, smoking, and physical activity—we constructed an equally weighted OBS categorized into quartiles, with higher scores representing greater antioxidant balance. Cox proportional hazards models were fitted to evaluate the association between the OBS and mortality.
Results
A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3–14.9), 421 deaths were identified, including 80 deaths from cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders, the hazard ratios and 95% confidence interval (CIs) between the highest quartile (predominance of antioxidants)
vs.
the lowest quartile (reference category) were 0.35 (95% CI 0.22–0.54,
P
-trend |
| doi_str_mv | 10.1007/s00394-023-03099-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10195723</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2776517561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-80af9aadfaa986ee8e51e8b7b35e4be3a3c5c4ea664c9f00f951a95b68a25a883</originalsourceid><addsrcrecordid>eNp9kU1vEzEQhq0KRD_gD_SALHHhssVer796QVVFW6QKDtCzNevMNq42drA3hfz7Ok0JlAMnW36feWc8LyHHnJ1wxvSHwpiwXcNa0TDBrG3MHjngnVCNarl8sbszvU8OS7ljrKKKvyL7QmnDu7Y9IMNZKckHmEKKtMfpJ2KkEGn6FWb18R5pDyNEj7T4lLFKM7pIeYIxTOtTCnSZU1mif0QhwrguodAQ6TRH-u3mC_VpXvHX5OUAY8E3T-cRubn49P38qrn-evn5_Oy68Z2WU2MYDBZgNgBYoxANSo6m172Q2PUoQHjpOwSlOm8HxgYrOVjZKwOtBGPEEfm49V2u-gXOPMYpw-iWOSwgr12C4J4rMczdbbp3nHErdSuqw_snh5x-rLBMbhGKx7EuAdOquFZrJbmWilf03T_oXVrluoNKGS5ZJ5XYjNRuKV83VTIOu2k4c5sc3TZHV8Nxjzm6TdHbv_-xK_kdXAXEFihVireY__T-j-0D1IGq2Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2815045638</pqid></control><display><type>article</type><title>Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Talavera-Rodriguez, Irene ; Fernandez-Lazaro, Cesar I. ; Hernández-Ruiz, Ángela ; Hershey, Maria S. ; Galarregui, Cristina ; Sotos-Prieto, Mercedes ; de la Fuente-Arrillaga, Carmen ; Martínez-González, Miguel Ángel ; Ruiz-Canela, Miguel</creator><creatorcontrib>Talavera-Rodriguez, Irene ; Fernandez-Lazaro, Cesar I. ; Hernández-Ruiz, Ángela ; Hershey, Maria S. ; Galarregui, Cristina ; Sotos-Prieto, Mercedes ; de la Fuente-Arrillaga, Carmen ; Martínez-González, Miguel Ángel ; Ruiz-Canela, Miguel</creatorcontrib><description>Purpose
We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates.
Methods
Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures—vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index, alcohol, smoking, and physical activity—we constructed an equally weighted OBS categorized into quartiles, with higher scores representing greater antioxidant balance. Cox proportional hazards models were fitted to evaluate the association between the OBS and mortality.
Results
A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3–14.9), 421 deaths were identified, including 80 deaths from cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders, the hazard ratios and 95% confidence interval (CIs) between the highest quartile (predominance of antioxidants)
vs.
the lowest quartile (reference category) were 0.35 (95% CI 0.22–0.54,
P
-trend < 0.001) for all-cause mortality, 0.18 (95% CI 0.06–0.51,
P
-trend = 0.001) for CVD mortality, 0.35 (95% CI 0.19–0.65,
P
-trend = 0.002) for cancer mortality, and 0.45 (95% CI 0.20–1.02,
P
-trend = 0.054) for other-cause mortality.
Conclusion
Our findings suggest a strong inverse association between the OBS and all-cause, CVD, and cancer mortality. Individuals exposed to both antioxidant dietary and lifestyle factors may potentially experience the lowest mortality risk.
Study registry number
Dynamic Mediterranean Prospective Cohort: the SUN Project; NCT02669602.
https://clinicaltrials.gov/ct2/show/NCT02669602
.
https://proyectosun.es</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-023-03099-8</identifier><identifier>PMID: 36781422</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Antioxidants ; Antioxidants - metabolism ; Body mass index ; Cancer ; Cardiovascular Diseases ; Chemistry ; Chemistry and Materials Science ; Diet ; Female ; Heme ; Humans ; Male ; Mortality ; NCT ; NCT02669602 ; Neoplasms ; Nutrition ; Original Contribution ; Oxidative Stress ; Physical activity ; Polyphenols ; Risk Factors ; Selenium ; Spain - epidemiology ; Vitamins</subject><ispartof>European journal of nutrition, 2023-06, Vol.62 (4), p.1667-1680</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-80af9aadfaa986ee8e51e8b7b35e4be3a3c5c4ea664c9f00f951a95b68a25a883</citedby><cites>FETCH-LOGICAL-c475t-80af9aadfaa986ee8e51e8b7b35e4be3a3c5c4ea664c9f00f951a95b68a25a883</cites><orcidid>0000-0003-2366-2528 ; 0000-0002-7684-2787</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-023-03099-8$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-023-03099-8$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36781422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Talavera-Rodriguez, Irene</creatorcontrib><creatorcontrib>Fernandez-Lazaro, Cesar I.</creatorcontrib><creatorcontrib>Hernández-Ruiz, Ángela</creatorcontrib><creatorcontrib>Hershey, Maria S.</creatorcontrib><creatorcontrib>Galarregui, Cristina</creatorcontrib><creatorcontrib>Sotos-Prieto, Mercedes</creatorcontrib><creatorcontrib>de la Fuente-Arrillaga, Carmen</creatorcontrib><creatorcontrib>Martínez-González, Miguel Ángel</creatorcontrib><creatorcontrib>Ruiz-Canela, Miguel</creatorcontrib><title>Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates.
Methods
Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures—vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index, alcohol, smoking, and physical activity—we constructed an equally weighted OBS categorized into quartiles, with higher scores representing greater antioxidant balance. Cox proportional hazards models were fitted to evaluate the association between the OBS and mortality.
Results
A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3–14.9), 421 deaths were identified, including 80 deaths from cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders, the hazard ratios and 95% confidence interval (CIs) between the highest quartile (predominance of antioxidants)
vs.
the lowest quartile (reference category) were 0.35 (95% CI 0.22–0.54,
P
-trend < 0.001) for all-cause mortality, 0.18 (95% CI 0.06–0.51,
P
-trend = 0.001) for CVD mortality, 0.35 (95% CI 0.19–0.65,
P
-trend = 0.002) for cancer mortality, and 0.45 (95% CI 0.20–1.02,
P
-trend = 0.054) for other-cause mortality.
Conclusion
Our findings suggest a strong inverse association between the OBS and all-cause, CVD, and cancer mortality. Individuals exposed to both antioxidant dietary and lifestyle factors may potentially experience the lowest mortality risk.
Study registry number
Dynamic Mediterranean Prospective Cohort: the SUN Project; NCT02669602.
https://clinicaltrials.gov/ct2/show/NCT02669602
.
https://proyectosun.es</description><subject>Adult</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Body mass index</subject><subject>Cancer</subject><subject>Cardiovascular Diseases</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Diet</subject><subject>Female</subject><subject>Heme</subject><subject>Humans</subject><subject>Male</subject><subject>Mortality</subject><subject>NCT</subject><subject>NCT02669602</subject><subject>Neoplasms</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Oxidative Stress</subject><subject>Physical activity</subject><subject>Polyphenols</subject><subject>Risk Factors</subject><subject>Selenium</subject><subject>Spain - epidemiology</subject><subject>Vitamins</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kU1vEzEQhq0KRD_gD_SALHHhssVer796QVVFW6QKDtCzNevMNq42drA3hfz7Ok0JlAMnW36feWc8LyHHnJ1wxvSHwpiwXcNa0TDBrG3MHjngnVCNarl8sbszvU8OS7ljrKKKvyL7QmnDu7Y9IMNZKckHmEKKtMfpJ2KkEGn6FWb18R5pDyNEj7T4lLFKM7pIeYIxTOtTCnSZU1mif0QhwrguodAQ6TRH-u3mC_VpXvHX5OUAY8E3T-cRubn49P38qrn-evn5_Oy68Z2WU2MYDBZgNgBYoxANSo6m172Q2PUoQHjpOwSlOm8HxgYrOVjZKwOtBGPEEfm49V2u-gXOPMYpw-iWOSwgr12C4J4rMczdbbp3nHErdSuqw_snh5x-rLBMbhGKx7EuAdOquFZrJbmWilf03T_oXVrluoNKGS5ZJ5XYjNRuKV83VTIOu2k4c5sc3TZHV8Nxjzm6TdHbv_-xK_kdXAXEFihVireY__T-j-0D1IGq2Q</recordid><startdate>20230601</startdate><enddate>20230601</enddate><creator>Talavera-Rodriguez, Irene</creator><creator>Fernandez-Lazaro, Cesar I.</creator><creator>Hernández-Ruiz, Ángela</creator><creator>Hershey, Maria S.</creator><creator>Galarregui, Cristina</creator><creator>Sotos-Prieto, Mercedes</creator><creator>de la Fuente-Arrillaga, Carmen</creator><creator>Martínez-González, Miguel Ángel</creator><creator>Ruiz-Canela, Miguel</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2366-2528</orcidid><orcidid>https://orcid.org/0000-0002-7684-2787</orcidid></search><sort><creationdate>20230601</creationdate><title>Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort</title><author>Talavera-Rodriguez, Irene ; Fernandez-Lazaro, Cesar I. ; Hernández-Ruiz, Ángela ; Hershey, Maria S. ; Galarregui, Cristina ; Sotos-Prieto, Mercedes ; de la Fuente-Arrillaga, Carmen ; Martínez-González, Miguel Ángel ; Ruiz-Canela, Miguel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-80af9aadfaa986ee8e51e8b7b35e4be3a3c5c4ea664c9f00f951a95b68a25a883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Body mass index</topic><topic>Cancer</topic><topic>Cardiovascular Diseases</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Diet</topic><topic>Female</topic><topic>Heme</topic><topic>Humans</topic><topic>Male</topic><topic>Mortality</topic><topic>NCT</topic><topic>NCT02669602</topic><topic>Neoplasms</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Oxidative Stress</topic><topic>Physical activity</topic><topic>Polyphenols</topic><topic>Risk Factors</topic><topic>Selenium</topic><topic>Spain - epidemiology</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Talavera-Rodriguez, Irene</creatorcontrib><creatorcontrib>Fernandez-Lazaro, Cesar I.</creatorcontrib><creatorcontrib>Hernández-Ruiz, Ángela</creatorcontrib><creatorcontrib>Hershey, Maria S.</creatorcontrib><creatorcontrib>Galarregui, Cristina</creatorcontrib><creatorcontrib>Sotos-Prieto, Mercedes</creatorcontrib><creatorcontrib>de la Fuente-Arrillaga, Carmen</creatorcontrib><creatorcontrib>Martínez-González, Miguel Ángel</creatorcontrib><creatorcontrib>Ruiz-Canela, Miguel</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Talavera-Rodriguez, Irene</au><au>Fernandez-Lazaro, Cesar I.</au><au>Hernández-Ruiz, Ángela</au><au>Hershey, Maria S.</au><au>Galarregui, Cristina</au><au>Sotos-Prieto, Mercedes</au><au>de la Fuente-Arrillaga, Carmen</au><au>Martínez-González, Miguel Ángel</au><au>Ruiz-Canela, Miguel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2023-06-01</date><risdate>2023</risdate><volume>62</volume><issue>4</issue><spage>1667</spage><epage>1680</epage><pages>1667-1680</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates.
Methods
Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures—vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index, alcohol, smoking, and physical activity—we constructed an equally weighted OBS categorized into quartiles, with higher scores representing greater antioxidant balance. Cox proportional hazards models were fitted to evaluate the association between the OBS and mortality.
Results
A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3–14.9), 421 deaths were identified, including 80 deaths from cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders, the hazard ratios and 95% confidence interval (CIs) between the highest quartile (predominance of antioxidants)
vs.
the lowest quartile (reference category) were 0.35 (95% CI 0.22–0.54,
P
-trend < 0.001) for all-cause mortality, 0.18 (95% CI 0.06–0.51,
P
-trend = 0.001) for CVD mortality, 0.35 (95% CI 0.19–0.65,
P
-trend = 0.002) for cancer mortality, and 0.45 (95% CI 0.20–1.02,
P
-trend = 0.054) for other-cause mortality.
Conclusion
Our findings suggest a strong inverse association between the OBS and all-cause, CVD, and cancer mortality. Individuals exposed to both antioxidant dietary and lifestyle factors may potentially experience the lowest mortality risk.
Study registry number
Dynamic Mediterranean Prospective Cohort: the SUN Project; NCT02669602.
https://clinicaltrials.gov/ct2/show/NCT02669602
.
https://proyectosun.es</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36781422</pmid><doi>10.1007/s00394-023-03099-8</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-2366-2528</orcidid><orcidid>https://orcid.org/0000-0002-7684-2787</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of nutrition, 2023-06, Vol.62 (4), p.1667-1680 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Antioxidants Antioxidants - metabolism Body mass index Cancer Cardiovascular Diseases Chemistry Chemistry and Materials Science Diet Female Heme Humans Male Mortality NCT NCT02669602 Neoplasms Nutrition Original Contribution Oxidative Stress Physical activity Polyphenols Risk Factors Selenium Spain - epidemiology Vitamins |
| title | Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort |
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