Epstein-Barr virus LMP1 protein promotes proliferation and inhibits differentiation of epithelial cells via activation of YAP and TAZ

Latent Epstein-Barr virus (EBV) infection promotes undifferentiated nasopharyngeal carcinomas (NPCs) in humans, but the mechanism(s) for this effect has been difficult to study because EBV cannot transform normal epithelial cells in vitro and the EBV genome is often lost when NPC cells are grown in...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-05, Vol.120 (20), p.e2219755120-e2219755120
Hauptverfasser:	Singh, Deo R, Nelson, Scott E, Pawelski, Abigail S, Kansra, Alisha S, Fogarty, Stuart A, Bristol, Jillian A, Ohashi, Makoto, Johannsen, Eric C, Kenney, Shannon C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Bruton's tyrosine kinase Carcinoma Cell activation Cell culture Cell Differentiation Cell Proliferation Differentiation Epithelial cells Epithelial Cells - metabolism Epithelium Epstein-Barr virus Epstein-Barr Virus Infections Genomes Growth factors Herpesvirus 4, Human - genetics Humans Keratinocytes Kinases Latent membrane protein 1 LMP1 protein Membrane proteins Nasopharyngeal Neoplasms - genetics Phosphorylation Proteins Telomerase Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism Viruses YAP-Signaling Proteins Yes-associated protein
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