ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway

Bone marrow stromal antigen 2 (BST2)/tetherin is a restriction factor that reduces HIV-1 dissemination by tethering virus at the cell surface. BST2 also acts as a sensor of HIV-1 budding, establishing a cellular antiviral state. The HIV-1 Vpu protein antagonizes BST2 antiviral functions via multiple...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2023-05, Vol.120 (20), p.e2217451120-e2217451120
Hauptverfasser:	Judith, Delphine, Versapuech, Margaux, Bejjani, Fabienne, Palaric, Marjory, Verlhac, Pauline, Kuster, Aurelia, Lepont, Leslie, Gallois-Montbrun, Sarah, Janvier, Katy, Berlioz-Torrent, Clarisse
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - metabolism Biological Sciences Bone Marrow Stromal Antigen 2 Cell Membrane - metabolism GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Human Immunodeficiency Virus Proteins - genetics Human Immunodeficiency Virus Proteins - metabolism Humans Life Sciences Viral Proteins - metabolism Viral Regulatory and Accessory Proteins - genetics Viral Regulatory and Accessory Proteins - metabolism Viruses - metabolism
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