Skeletal muscle Nox4 knockout prevents and Nox2 knockout blunts loss of maximal diaphragm force in mice with heart failure with reduced ejection fraction

Patients with heart failure with reduced ejection fraction (HFrEF) experience diaphragm weakness that contributes to the primary disease symptoms of fatigue, dyspnea, and exercise intolerance. Weakness in the diaphragm is related to excessive production of reactive oxygen species (ROS), but the exac...

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Veröffentlicht in:Free radical biology & medicine 2023-01, Vol.194, p.23-32
Hauptverfasser: Kumar, Ravi A., Hahn, Dongwoo, Kelley, Rachel C., Muscato, Derek R., Shamoun, Alex, Curbelo-Bermudez, Nuria, Butler, W. Greyson, Yegorova, Svetlana, Ryan, Terence E., Ferreira, Leonardo F.
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