Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma

Paclitaxel (PTX) is one of the most potent and commonly used chemotherapies for breast and pancreatic cancer. Several ongoing clinical trials are investigating means of enhancing delivery of PTX across the blood-brain barrier for glioblastomas. Despite the widespread use of PTX for breast cancer, an...

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Veröffentlicht in:	Clinical cancer research 2022-07, Vol.28 (14), p.3156-3169
Hauptverfasser:	Dmello, Crismita, Sonabend, Aarón, Arrieta, Victor A, Zhang, Daniel Y, Kanojia, Deepak, Chen, Li, Gould, Andrew, Zhang, Jiangshan, Kang, Seong Jae, Winter, Jan, Horbinski, Craig, Amidei, Christina, Győrffy, Balázs, Cordero, Alex, Chang, Catalina Lee, Castro, Brandyn, Hsu, Patrick, Ahmed, Atique U, Lesniak, Maciej S, Stupp, Roger, Sonabend, Adam M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - therapeutic use Biomarkers, Pharmacological Brain Neoplasms - drug therapy Brain Neoplasms - genetics Breast Neoplasms - drug therapy Breast Neoplasms - genetics Calcium-Binding Proteins - genetics Cell Line, Tumor Drug Resistance, Neoplasm - genetics Endoribonucleases - metabolism Female Glioblastoma - drug therapy Glioblastoma - genetics Humans Membrane Glycoproteins - genetics Mice Paclitaxel - therapeutic use Prospective Studies Protein Serine-Threonine Kinases - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Peptide - genetics Xenograft Model Antitumor Assays
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