Viability of autologous fascia lata in heart valve replacements
A histological and radioautographic examination of 11 autologous fascia lata heart valves used in man is described. There was a significant decrease, exponential with time, in the number of fibroblasts per unit volume (P
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| Veröffentlicht in: | Thorax 1971-05, Vol.26 (3), p.277-283 |
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| container_title | Thorax |
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| creator | Lincoln, J. C. R. Riley, P. A. Revignas, A. Geens, M. Ross, D. N. Ross, J. K. |
| description | A histological and radioautographic examination of 11 autologous fascia lata heart valves used in man is described. There was a significant decrease, exponential with time, in the number of fibroblasts per unit volume (P |
| doi_str_mv | 10.1136/thx.26.3.277 |
| format | Article |
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C. R. ; Riley, P. A. ; Revignas, A. ; Geens, M. ; Ross, D. N. ; Ross, J. K.</creator><creatorcontrib>Lincoln, J. C. R. ; Riley, P. A. ; Revignas, A. ; Geens, M. ; Ross, D. N. ; Ross, J. K.</creatorcontrib><description>A histological and radioautographic examination of 11 autologous fascia lata heart valves used in man is described. There was a significant decrease, exponential with time, in the number of fibroblasts per unit volume (P<0·001). The collagen bundles were grossly disorganized and separated, suggesting a breakdown of the cross-linkage in the tissue. Redundant connective tissue on the surface of the valve cusp became oedematous and contained many trapped cells. A pseudoendothelium was formed within 10 days. Incorporation of tritium-labelled thymidine in the nuclei of the fibroblasts showed a sixfold reduction over 9 to 12 weeks following implantation, suggesting a failure of metabolism in these cells. The suitability of fascia lata for human heart valve replacement is discussed.</description><identifier>ISSN: 0040-6376</identifier><identifier>EISSN: 1468-3296</identifier><identifier>DOI: 10.1136/thx.26.3.277</identifier><identifier>PMID: 5089492</identifier><identifier>CODEN: THORA7</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Thoracic Society</publisher><subject>Aortic Valve ; Autoradiography ; Collagen ; Fascia - cytology ; Fascia - pathology ; Fascia - transplantation ; Fibroblasts ; Heart Valve Prosthesis ; Humans ; Mitral Valve ; Thymidine - metabolism ; Time Factors ; Transplantation, Autologous ; Tritium</subject><ispartof>Thorax, 1971-05, Vol.26 (3), p.277-283</ispartof><rights>Copyright BMJ Publishing Group LTD May 1971</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b477t-1705085f672577f1ea2f3d5b7a35421fae59c21e198d1bddef0da036d65409a33</citedby><cites>FETCH-LOGICAL-b477t-1705085f672577f1ea2f3d5b7a35421fae59c21e198d1bddef0da036d65409a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1019082/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1019082/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5089492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lincoln, J. C. R.</creatorcontrib><creatorcontrib>Riley, P. A.</creatorcontrib><creatorcontrib>Revignas, A.</creatorcontrib><creatorcontrib>Geens, M.</creatorcontrib><creatorcontrib>Ross, D. N.</creatorcontrib><creatorcontrib>Ross, J. K.</creatorcontrib><title>Viability of autologous fascia lata in heart valve replacements</title><title>Thorax</title><addtitle>Thorax</addtitle><description>A histological and radioautographic examination of 11 autologous fascia lata heart valves used in man is described. There was a significant decrease, exponential with time, in the number of fibroblasts per unit volume (P<0·001). The collagen bundles were grossly disorganized and separated, suggesting a breakdown of the cross-linkage in the tissue. Redundant connective tissue on the surface of the valve cusp became oedematous and contained many trapped cells. A pseudoendothelium was formed within 10 days. Incorporation of tritium-labelled thymidine in the nuclei of the fibroblasts showed a sixfold reduction over 9 to 12 weeks following implantation, suggesting a failure of metabolism in these cells. The suitability of fascia lata for human heart valve replacement is discussed.</description><subject>Aortic Valve</subject><subject>Autoradiography</subject><subject>Collagen</subject><subject>Fascia - cytology</subject><subject>Fascia - pathology</subject><subject>Fascia - transplantation</subject><subject>Fibroblasts</subject><subject>Heart Valve Prosthesis</subject><subject>Humans</subject><subject>Mitral Valve</subject><subject>Thymidine - metabolism</subject><subject>Time Factors</subject><subject>Transplantation, Autologous</subject><subject>Tritium</subject><issn>0040-6376</issn><issn>1468-3296</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kc1v1DAUxC0EKtuWG1ekSEjlQrZ-dmwnFyq06gdixYdUerVeEqfrxUkW21m1_z2udrUCDpzeYX6amach5DXQOQCX53H1MGdyzudMqWdkBoUsc84q-ZzMKC1oLrmSL8lxCGtKaQmgjsiRoGVVVGxGLu4s1tbZ-JiNXYZTHN14P04h6zA0FjOHETM7ZCuDPmZbdFuTebNx2JjeDDGckhcdumBe7e8J-XF1ebu4yZdfrz8tPi7zulAq5qBoihSdVEwo1YFB1vFW1Aq5KBh0aETVMDBQlS3UbWs62iLlspWioBVyfkI-7Hw3U92btknZHp3eeNujf9QjWv23MtiVvh-3GihUtGTJ4Gxv4MdfkwlR9zY0xjkcTPpXq6JUUDFI4Nt_wPU4-SE9p0EpYMlLPfV5v6MaP4bgTXeoAlQ_zaLTLJpJzXWaJeFv_qx_gPc7JD3f6TZE83CQ0f_UUnEl9Je7hf62vL65_Xz1XYvEv9vxdb_-f_Jvsq-k0A</recordid><startdate>19710501</startdate><enddate>19710501</enddate><creator>Lincoln, J. C. R.</creator><creator>Riley, P. A.</creator><creator>Revignas, A.</creator><creator>Geens, M.</creator><creator>Ross, D. N.</creator><creator>Ross, J. 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K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b477t-1705085f672577f1ea2f3d5b7a35421fae59c21e198d1bddef0da036d65409a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Aortic Valve</topic><topic>Autoradiography</topic><topic>Collagen</topic><topic>Fascia - cytology</topic><topic>Fascia - pathology</topic><topic>Fascia - transplantation</topic><topic>Fibroblasts</topic><topic>Heart Valve Prosthesis</topic><topic>Humans</topic><topic>Mitral Valve</topic><topic>Thymidine - metabolism</topic><topic>Time Factors</topic><topic>Transplantation, Autologous</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lincoln, J. C. R.</creatorcontrib><creatorcontrib>Riley, P. A.</creatorcontrib><creatorcontrib>Revignas, A.</creatorcontrib><creatorcontrib>Geens, M.</creatorcontrib><creatorcontrib>Ross, D. 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C. R.</au><au>Riley, P. A.</au><au>Revignas, A.</au><au>Geens, M.</au><au>Ross, D. N.</au><au>Ross, J. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Viability of autologous fascia lata in heart valve replacements</atitle><jtitle>Thorax</jtitle><addtitle>Thorax</addtitle><date>1971-05-01</date><risdate>1971</risdate><volume>26</volume><issue>3</issue><spage>277</spage><epage>283</epage><pages>277-283</pages><issn>0040-6376</issn><eissn>1468-3296</eissn><coden>THORA7</coden><abstract>A histological and radioautographic examination of 11 autologous fascia lata heart valves used in man is described. There was a significant decrease, exponential with time, in the number of fibroblasts per unit volume (P<0·001). The collagen bundles were grossly disorganized and separated, suggesting a breakdown of the cross-linkage in the tissue. Redundant connective tissue on the surface of the valve cusp became oedematous and contained many trapped cells. A pseudoendothelium was formed within 10 days. Incorporation of tritium-labelled thymidine in the nuclei of the fibroblasts showed a sixfold reduction over 9 to 12 weeks following implantation, suggesting a failure of metabolism in these cells. The suitability of fascia lata for human heart valve replacement is discussed.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Thoracic Society</pub><pmid>5089492</pmid><doi>10.1136/thx.26.3.277</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Thorax, 1971-05, Vol.26 (3), p.277-283 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aortic Valve Autoradiography Collagen Fascia - cytology Fascia - pathology Fascia - transplantation Fibroblasts Heart Valve Prosthesis Humans Mitral Valve Thymidine - metabolism Time Factors Transplantation, Autologous Tritium |
| title | Viability of autologous fascia lata in heart valve replacements |
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