Development of Drug Release Model for Suspensions in ESCAR (Emulator of SubCutaneous Absorption and Release)
We recently developed an in vitro testing system, namely, ESCAR (Emulator of SubCutaneous Absorption and Release). The objective of this work was to investigate drug release behaviors of unmilled and milled suspensions in ESCAR. A mass transport-based model was developed to describe the multi-step d...
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| Veröffentlicht in: | The AAPS journal 2023-03, Vol.25 (3), p.29-29, Article 29 |
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| creator | Lou, Hao Hageman, Michael J. |
| description | We recently developed an
in vitro
testing system, namely, ESCAR (Emulator of SubCutaneous Absorption and Release). The objective of this work was to investigate drug release behaviors of unmilled and milled suspensions in ESCAR. A mass transport-based model was developed to describe the multi-step drug release process, including drug dissolution, particle settling, drug distribution/partition, and drug permeation through the membrane(s). To address the particle settling effect, a correction factor was included in the model and its value was obtained by data fitting. It was found that, for both suspensions, (i) the experimental data of various dose/formulation combinations could be fit by the developed model; (ii) the dose effect on drug release was offset by the particle settling effect. This model may help to reduce experimental efforts and facilitate subcutaneous suspension formulation development using ESCAR.
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| doi_str_mv | 10.1208/s12248-023-00799-1 |
| format | Article |
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testing system, namely, ESCAR (Emulator of SubCutaneous Absorption and Release). The objective of this work was to investigate drug release behaviors of unmilled and milled suspensions in ESCAR. A mass transport-based model was developed to describe the multi-step drug release process, including drug dissolution, particle settling, drug distribution/partition, and drug permeation through the membrane(s). To address the particle settling effect, a correction factor was included in the model and its value was obtained by data fitting. It was found that, for both suspensions, (i) the experimental data of various dose/formulation combinations could be fit by the developed model; (ii) the dose effect on drug release was offset by the particle settling effect. This model may help to reduce experimental efforts and facilitate subcutaneous suspension formulation development using ESCAR.
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testing system, namely, ESCAR (Emulator of SubCutaneous Absorption and Release). The objective of this work was to investigate drug release behaviors of unmilled and milled suspensions in ESCAR. A mass transport-based model was developed to describe the multi-step drug release process, including drug dissolution, particle settling, drug distribution/partition, and drug permeation through the membrane(s). To address the particle settling effect, a correction factor was included in the model and its value was obtained by data fitting. It was found that, for both suspensions, (i) the experimental data of various dose/formulation combinations could be fit by the developed model; (ii) the dose effect on drug release was offset by the particle settling effect. This model may help to reduce experimental efforts and facilitate subcutaneous suspension formulation development using ESCAR.
Graphical Abstract</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Drug Liberation</subject><subject>Particle Size</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Research Article</subject><subject>Solubility</subject><subject>Subcutaneous Absorption</subject><subject>Suspensions</subject><issn>1550-7416</issn><issn>1550-7416</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr3DAUhU1paR7tH-iiCLpJFk71trUqw2SSFhIKmXYtZPl66iBLrmQH-u-riZOQQClaSOh-50iHUxQfCD4jFNefE6GU1yWmrMS4Uqokr4pDIgQuK07k62fng-IopVuMGWWEvC0OmFRcMUwOC3cOd-DCOICfUOjQeZx36AYcmAToOrTgUBci2s5pBJ_64BPqPdps16sbdLIZZmemPM7C7dys58l4CHNCqyaFOE4ZR8a3j36n74o3nXEJ3j_sx8XPi82P9dfy6vvlt_XqqrSC8KkU2LaSC2mFqA2jlvIG1wp4K6SppOkEA0yFrBvbQN1AQ7BoqFISMsyUVOy4-LL4jnMzQGtztmicHmM_mPhHB9PrlxPf_9K7cKcJJjWva5kdTh4cYvg9Q5r00CcLzi0BNa0UxoJU1f6xTwu6Mw5077uQLe0e16uK0wozomimzv5B5dXC0Nvgoevz_QsBXQQ2hpQidE_fJ1jv69dL_TrXr-_r1ySLPj4P_iR57DsDbAFSHvkdRH0b5uhzGf-z_QsbQ7n5</recordid><startdate>20230322</startdate><enddate>20230322</enddate><creator>Lou, Hao</creator><creator>Hageman, Michael J.</creator><general>Springer International Publishing</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230322</creationdate><title>Development of Drug Release Model for Suspensions in ESCAR (Emulator of SubCutaneous Absorption and Release)</title><author>Lou, Hao ; Hageman, Michael J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c514t-50cd6456c558a32c24b089e4d56a76af53e02568bcbe8beb105b2996ea3239693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Drug Liberation</topic><topic>Particle Size</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Research Article</topic><topic>Solubility</topic><topic>Subcutaneous Absorption</topic><topic>Suspensions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lou, Hao</creatorcontrib><creatorcontrib>Hageman, Michael J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The AAPS journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lou, Hao</au><au>Hageman, Michael J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of Drug Release Model for Suspensions in ESCAR (Emulator of SubCutaneous Absorption and Release)</atitle><jtitle>The AAPS journal</jtitle><stitle>AAPS J</stitle><addtitle>AAPS J</addtitle><date>2023-03-22</date><risdate>2023</risdate><volume>25</volume><issue>3</issue><spage>29</spage><epage>29</epage><pages>29-29</pages><artnum>29</artnum><issn>1550-7416</issn><eissn>1550-7416</eissn><abstract>We recently developed an
in vitro
testing system, namely, ESCAR (Emulator of SubCutaneous Absorption and Release). The objective of this work was to investigate drug release behaviors of unmilled and milled suspensions in ESCAR. A mass transport-based model was developed to describe the multi-step drug release process, including drug dissolution, particle settling, drug distribution/partition, and drug permeation through the membrane(s). To address the particle settling effect, a correction factor was included in the model and its value was obtained by data fitting. It was found that, for both suspensions, (i) the experimental data of various dose/formulation combinations could be fit by the developed model; (ii) the dose effect on drug release was offset by the particle settling effect. This model may help to reduce experimental efforts and facilitate subcutaneous suspension formulation development using ESCAR.
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| ispartof | The AAPS journal, 2023-03, Vol.25 (3), p.29-29, Article 29 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Drug Liberation Particle Size Pharmacology/Toxicology Pharmacy Research Article Solubility Subcutaneous Absorption Suspensions |
| title | Development of Drug Release Model for Suspensions in ESCAR (Emulator of SubCutaneous Absorption and Release) |
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