Influence of Serum Uric Acid on Macular Choroidal Thickness and Ganglion Cell Inner Plexiform Layer Thickness
The purpose of this study was to determine the influence of serum uric acid (UA) on macular choroidal and ganglion cell inner plexiform layer (GC-IPL) thickness. This cross-sectional study enrolled adult individuals in communities in Guangzhou, China. All participants underwent a comprehensive ophth...
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| Veröffentlicht in: | Translational vision science & technology 2023-05, Vol.12 (5), p.13-13 |
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| creator | Xiong, Kun Gong, Xia Xie, Liqiong Wang, Lanhua Guo, Xiao Li, Wangting Zhong, Pingting Liang, Xiaoling Huang, Wenyong Wang, Wei |
| description | The purpose of this study was to determine the influence of serum uric acid (UA) on macular choroidal and ganglion cell inner plexiform layer (GC-IPL) thickness.
This cross-sectional study enrolled adult individuals in communities in Guangzhou, China. All participants underwent a comprehensive ophthalmologic examination. They were divided into four groups according to UA quartiles. The choroidal and GC-IPL thickness was measured by swept-source optical coherence tomography (SS-OCT).
A total of 719 subjects (1389 eyes) were included in the study. The average UA was 348.50 ± 86.16 mmol/L. The average choroidal and GC-IPL thickness decreased with UA quartiles (P < 0.001). Multivariate linear regression analyses showed that UA was negatively associated with average choroidal (β = -0.073, 95% confidence interval [CI] = -0.117 to -0.028, P = 0.001) and GC-IPL thickness (β = -0.006, 95% CI = -0.009 to -0.002, P = 0.001). After adjusting for confounding factors, the average choroidal thickness was decreased in quartile 4 as compared with quartile 1 by -14.737 µm (95% CI = -24.460 to -5.015, P = 0.003). The average GC-IPL thickness was decreased in quartile 4 versus quartile 1 by -1.028 (95% CI = -1.873 to -0.290, P = 0.007).
Higher UA levels were independently associated with macular choroid and GC-IPL thinning. These contribute to a better understanding of ocular pathological mechanisms.
The associated UA with choroidal and GC-IPL thickness helps to understand the ocular pathological and retinal neurodegenerative mechanism. |
| doi_str_mv | 10.1167/tvst.12.5.13 |
| format | Article |
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This cross-sectional study enrolled adult individuals in communities in Guangzhou, China. All participants underwent a comprehensive ophthalmologic examination. They were divided into four groups according to UA quartiles. The choroidal and GC-IPL thickness was measured by swept-source optical coherence tomography (SS-OCT).
A total of 719 subjects (1389 eyes) were included in the study. The average UA was 348.50 ± 86.16 mmol/L. The average choroidal and GC-IPL thickness decreased with UA quartiles (P < 0.001). Multivariate linear regression analyses showed that UA was negatively associated with average choroidal (β = -0.073, 95% confidence interval [CI] = -0.117 to -0.028, P = 0.001) and GC-IPL thickness (β = -0.006, 95% CI = -0.009 to -0.002, P = 0.001). After adjusting for confounding factors, the average choroidal thickness was decreased in quartile 4 as compared with quartile 1 by -14.737 µm (95% CI = -24.460 to -5.015, P = 0.003). The average GC-IPL thickness was decreased in quartile 4 versus quartile 1 by -1.028 (95% CI = -1.873 to -0.290, P = 0.007).
Higher UA levels were independently associated with macular choroid and GC-IPL thinning. These contribute to a better understanding of ocular pathological mechanisms.
The associated UA with choroidal and GC-IPL thickness helps to understand the ocular pathological and retinal neurodegenerative mechanism.</description><identifier>ISSN: 2164-2591</identifier><identifier>EISSN: 2164-2591</identifier><identifier>DOI: 10.1167/tvst.12.5.13</identifier><identifier>PMID: 37171795</identifier><language>eng</language><publisher>United States: The Association for Research in Vision and Ophthalmology</publisher><subject>Adult ; Choroid - diagnostic imaging ; Cross-Sectional Studies ; Humans ; Nerve Fibers - pathology ; Neuro-Ophthalmology ; Retinal Ganglion Cells - pathology ; Tomography, Optical Coherence - methods ; Uric Acid</subject><ispartof>Translational vision science & technology, 2023-05, Vol.12 (5), p.13-13</ispartof><rights>Copyright 2023 The Authors 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c342t-6325966d8b174d9828a1ce1a9591c5f346c33c5bb1f3d5ce46c12701e491bd4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184778/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184778/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37171795$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiong, Kun</creatorcontrib><creatorcontrib>Gong, Xia</creatorcontrib><creatorcontrib>Xie, Liqiong</creatorcontrib><creatorcontrib>Wang, Lanhua</creatorcontrib><creatorcontrib>Guo, Xiao</creatorcontrib><creatorcontrib>Li, Wangting</creatorcontrib><creatorcontrib>Zhong, Pingting</creatorcontrib><creatorcontrib>Liang, Xiaoling</creatorcontrib><creatorcontrib>Huang, Wenyong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>GDES group</creatorcontrib><creatorcontrib>on behalf of the GDES group</creatorcontrib><title>Influence of Serum Uric Acid on Macular Choroidal Thickness and Ganglion Cell Inner Plexiform Layer Thickness</title><title>Translational vision science & technology</title><addtitle>Transl Vis Sci Technol</addtitle><description>The purpose of this study was to determine the influence of serum uric acid (UA) on macular choroidal and ganglion cell inner plexiform layer (GC-IPL) thickness.
This cross-sectional study enrolled adult individuals in communities in Guangzhou, China. All participants underwent a comprehensive ophthalmologic examination. They were divided into four groups according to UA quartiles. The choroidal and GC-IPL thickness was measured by swept-source optical coherence tomography (SS-OCT).
A total of 719 subjects (1389 eyes) were included in the study. The average UA was 348.50 ± 86.16 mmol/L. The average choroidal and GC-IPL thickness decreased with UA quartiles (P < 0.001). Multivariate linear regression analyses showed that UA was negatively associated with average choroidal (β = -0.073, 95% confidence interval [CI] = -0.117 to -0.028, P = 0.001) and GC-IPL thickness (β = -0.006, 95% CI = -0.009 to -0.002, P = 0.001). After adjusting for confounding factors, the average choroidal thickness was decreased in quartile 4 as compared with quartile 1 by -14.737 µm (95% CI = -24.460 to -5.015, P = 0.003). The average GC-IPL thickness was decreased in quartile 4 versus quartile 1 by -1.028 (95% CI = -1.873 to -0.290, P = 0.007).
Higher UA levels were independently associated with macular choroid and GC-IPL thinning. These contribute to a better understanding of ocular pathological mechanisms.
The associated UA with choroidal and GC-IPL thickness helps to understand the ocular pathological and retinal neurodegenerative mechanism.</description><subject>Adult</subject><subject>Choroid - diagnostic imaging</subject><subject>Cross-Sectional Studies</subject><subject>Humans</subject><subject>Nerve Fibers - pathology</subject><subject>Neuro-Ophthalmology</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Uric Acid</subject><issn>2164-2591</issn><issn>2164-2591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1LxDAQhoMoKurNs-TowV07-Wp7Eln8WFhRUM8hTVM3miaatIv-eyPqoplDMswzb2Z4ETqEYgogytNhlYYpkCmfAt1AuwQEmxBew-af9w46SOm5yEdUnDGxjXZoCTlqvov6ue_caLw2OHT43sSxx4_RanyubYuDxzdKj05FPFuGGGyrHH5YWv3iTUpY-RZfKf_kbAZnxjk8995EfOfMu-1C7PFCfeR83bGPtjrlkjn4uffQ4-XFw-x6sri9ms_OFxNNGRkmgua5hWirBkrW1hWpFGgDqs7baN5RJjSlmjcNdLTl2uQcSFmAYTU0LdN0D519676OTW9abfwQlZOv0fYqfsigrPxf8XYpn8JKQgEVK8sqKxz_KMTwNpo0yN4mnVdU3oQxSVIB5ZyJkmT05BvVMaQUTbf-Bwr55ZL8ckkCkVwCzfjR39nW8K8n9BOdDI8k</recordid><startdate>20230501</startdate><enddate>20230501</enddate><creator>Xiong, Kun</creator><creator>Gong, Xia</creator><creator>Xie, Liqiong</creator><creator>Wang, Lanhua</creator><creator>Guo, Xiao</creator><creator>Li, Wangting</creator><creator>Zhong, Pingting</creator><creator>Liang, Xiaoling</creator><creator>Huang, Wenyong</creator><creator>Wang, Wei</creator><general>The Association for Research in Vision and Ophthalmology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230501</creationdate><title>Influence of Serum Uric Acid on Macular Choroidal Thickness and Ganglion Cell Inner Plexiform Layer Thickness</title><author>Xiong, Kun ; Gong, Xia ; Xie, Liqiong ; Wang, Lanhua ; Guo, Xiao ; Li, Wangting ; Zhong, Pingting ; Liang, Xiaoling ; Huang, Wenyong ; Wang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-6325966d8b174d9828a1ce1a9591c5f346c33c5bb1f3d5ce46c12701e491bd4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Choroid - diagnostic imaging</topic><topic>Cross-Sectional Studies</topic><topic>Humans</topic><topic>Nerve Fibers - pathology</topic><topic>Neuro-Ophthalmology</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Uric Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiong, Kun</creatorcontrib><creatorcontrib>Gong, Xia</creatorcontrib><creatorcontrib>Xie, Liqiong</creatorcontrib><creatorcontrib>Wang, Lanhua</creatorcontrib><creatorcontrib>Guo, Xiao</creatorcontrib><creatorcontrib>Li, Wangting</creatorcontrib><creatorcontrib>Zhong, Pingting</creatorcontrib><creatorcontrib>Liang, Xiaoling</creatorcontrib><creatorcontrib>Huang, Wenyong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><creatorcontrib>GDES group</creatorcontrib><creatorcontrib>on behalf of the GDES group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational vision science & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiong, Kun</au><au>Gong, Xia</au><au>Xie, Liqiong</au><au>Wang, Lanhua</au><au>Guo, Xiao</au><au>Li, Wangting</au><au>Zhong, Pingting</au><au>Liang, Xiaoling</au><au>Huang, Wenyong</au><au>Wang, Wei</au><aucorp>GDES group</aucorp><aucorp>on behalf of the GDES group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Serum Uric Acid on Macular Choroidal Thickness and Ganglion Cell Inner Plexiform Layer Thickness</atitle><jtitle>Translational vision science & technology</jtitle><addtitle>Transl Vis Sci Technol</addtitle><date>2023-05-01</date><risdate>2023</risdate><volume>12</volume><issue>5</issue><spage>13</spage><epage>13</epage><pages>13-13</pages><issn>2164-2591</issn><eissn>2164-2591</eissn><abstract>The purpose of this study was to determine the influence of serum uric acid (UA) on macular choroidal and ganglion cell inner plexiform layer (GC-IPL) thickness.
This cross-sectional study enrolled adult individuals in communities in Guangzhou, China. All participants underwent a comprehensive ophthalmologic examination. They were divided into four groups according to UA quartiles. The choroidal and GC-IPL thickness was measured by swept-source optical coherence tomography (SS-OCT).
A total of 719 subjects (1389 eyes) were included in the study. The average UA was 348.50 ± 86.16 mmol/L. The average choroidal and GC-IPL thickness decreased with UA quartiles (P < 0.001). Multivariate linear regression analyses showed that UA was negatively associated with average choroidal (β = -0.073, 95% confidence interval [CI] = -0.117 to -0.028, P = 0.001) and GC-IPL thickness (β = -0.006, 95% CI = -0.009 to -0.002, P = 0.001). After adjusting for confounding factors, the average choroidal thickness was decreased in quartile 4 as compared with quartile 1 by -14.737 µm (95% CI = -24.460 to -5.015, P = 0.003). The average GC-IPL thickness was decreased in quartile 4 versus quartile 1 by -1.028 (95% CI = -1.873 to -0.290, P = 0.007).
Higher UA levels were independently associated with macular choroid and GC-IPL thinning. These contribute to a better understanding of ocular pathological mechanisms.
The associated UA with choroidal and GC-IPL thickness helps to understand the ocular pathological and retinal neurodegenerative mechanism.</abstract><cop>United States</cop><pub>The Association for Research in Vision and Ophthalmology</pub><pmid>37171795</pmid><doi>10.1167/tvst.12.5.13</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 2164-2591 2164-2591 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Choroid - diagnostic imaging Cross-Sectional Studies Humans Nerve Fibers - pathology Neuro-Ophthalmology Retinal Ganglion Cells - pathology Tomography, Optical Coherence - methods Uric Acid |
| title | Influence of Serum Uric Acid on Macular Choroidal Thickness and Ganglion Cell Inner Plexiform Layer Thickness |
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