The Effect of Prognostic Nutritional Index in Postoperative Infection Following Lobectomy in Non-Small Cell Lung Cancer Patients
Background The prognostic nutritional index (PNI) is a valuable marker for evaluating the nutritional status associated with postoperative complications and the prognosis of patients with cancer. However, the role and clinical value of PNI in infection after lung cancer surgery remains unclear. This...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-04, Vol.15 (4), p.e37611-e37611 |
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| creator | Hazer, Seray Gülhan, Selim Şakir Erkmen Solak, Necati Yenibertiz, Derya Akıllı, Mahmut Sami Sayilir Guven, Ebru Bıçakçıoğlu, Pınar |
| description | Background The prognostic nutritional index (PNI) is a valuable marker for evaluating the nutritional status associated with postoperative complications and the prognosis of patients with cancer. However, the role and clinical value of PNI in infection after lung cancer surgery remains unclear. This study examined the association between PNI and infection after lobectomy for lung cancer, focusing on the predictive value of PNI. Methods We conducted this retrospective cohort study on 139 patients with non-small cell lung cancer (NSCLC) who underwent surgery between September 2013 and December 2018. Two groups were composed according to their PNI values (≥ 50 or |
| doi_str_mv | 10.7759/cureus.37611 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10184591</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2815250075</sourcerecordid><originalsourceid>FETCH-LOGICAL-c300t-6e6c76af5df210dc046255a340110568c08fd29988fda141da2deb78f09f29b3</originalsourceid><addsrcrecordid>eNpdkUFPGzEQha2qqCDKrefKUi89dOmMN157T1UVAUWKIBK5W47XDka7dmrv0nLrT8dpKKJcPNbM5zeeeYR8QDgVgrdfzZTslE9r0SC-IUcMG1lJlLO3L-6H5CTnOwBAEAwEvCOHtcBWYA1H5M_q1tIz56wZaXR0meImxDx6Q6-mMfnRx6B7ehk6-5v6QJelFrc26dHf25LevSsIPY99H3_5sKGLuC65ODzs8KsYqptB9z2d23IspgLMdTA20WWRsGHM78mB0322J0_xmKzOz1bzH9Xi-uJy_n1RmRpgrBrbGNFoxzvHEDoDs4ZxrusZIAJvpAHpOta2sgSNM-w06-xaSAetY-26Pibf9rLbaT3YzpTWSfdqm_yg04OK2qv_K8Hfqk28VwhlhbzFovD5SSHFn5PNoxp8NmUsHWycsmISOeMAghf00yv0Lk6pLHJHMWSNFDUU6sueMinmnKx7_g2C2rmr9u6qv-4W_OPLCZ7hf17Wj9rRous</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2821268730</pqid></control><display><type>article</type><title>The Effect of Prognostic Nutritional Index in Postoperative Infection Following Lobectomy in Non-Small Cell Lung Cancer Patients</title><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Hazer, Seray ; Gülhan, Selim Şakir Erkmen ; Solak, Necati ; Yenibertiz, Derya ; Akıllı, Mahmut Sami ; Sayilir Guven, Ebru ; Bıçakçıoğlu, Pınar</creator><creatorcontrib>Hazer, Seray ; Gülhan, Selim Şakir Erkmen ; Solak, Necati ; Yenibertiz, Derya ; Akıllı, Mahmut Sami ; Sayilir Guven, Ebru ; Bıçakçıoğlu, Pınar</creatorcontrib><description>Background The prognostic nutritional index (PNI) is a valuable marker for evaluating the nutritional status associated with postoperative complications and the prognosis of patients with cancer. However, the role and clinical value of PNI in infection after lung cancer surgery remains unclear. This study examined the association between PNI and infection after lobectomy for lung cancer, focusing on the predictive value of PNI. Methods We conducted this retrospective cohort study on 139 patients with non-small cell lung cancer (NSCLC) who underwent surgery between September 2013 and December 2018. Two groups were composed according to their PNI values (≥ 50 or <50 ), and the relationship was assessed with infection after lobectomy. Results Only PNI values, atelectasis, and prolonged air leaks were significantly associated with the development of infection. The median preoperative PNI was 52.97±5.69. Postoperative infection was seen in patients (15.5%) with PNI≥ 50 and 38.1% in patients with PNI <50. The mean PNI in patients with postoperative infection, empyema, and prolonged air leakage was lower than in patients without these conditions. Conclusions Malnutrition is commonly seen in patients with malignancy. The overall malnutrition rate is 45% in lung cancer patients. Patients with metastatic diseases are malnourished in a 73% ratio compared to 5% for localized diseases. Furthermore, malnutrition increases the tendency of postoperative infection and reduces wound healing. We aim to determine whether PNI can be a predictive index marker for postoperative infection in patients with NSCLC who underwent lobectomy. Postoperative infection was seen in 15.5% of patients with PNI>50 and 38.1% in patients with PNI <50.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.37611</identifier><identifier>PMID: 37197130</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Cardiac/Thoracic/Vascular Surgery ; Disease ; Dyspnea ; Females ; Hemoptysis ; Hospitals ; Infections ; Lung cancer ; Lymphatic system ; Lymphocytes ; Malnutrition ; Medical prognosis ; Normal distribution ; Ostomy ; Pathology ; Surgical techniques ; Thoracic surgery ; Wound healing</subject><ispartof>Curēus (Palo Alto, CA), 2023-04, Vol.15 (4), p.e37611-e37611</ispartof><rights>Copyright © 2023, Hazer et al.</rights><rights>Copyright © 2023, Hazer et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Hazer et al. 2023 Hazer et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c300t-6e6c76af5df210dc046255a340110568c08fd29988fda141da2deb78f09f29b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184591/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184591/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37197130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hazer, Seray</creatorcontrib><creatorcontrib>Gülhan, Selim Şakir Erkmen</creatorcontrib><creatorcontrib>Solak, Necati</creatorcontrib><creatorcontrib>Yenibertiz, Derya</creatorcontrib><creatorcontrib>Akıllı, Mahmut Sami</creatorcontrib><creatorcontrib>Sayilir Guven, Ebru</creatorcontrib><creatorcontrib>Bıçakçıoğlu, Pınar</creatorcontrib><title>The Effect of Prognostic Nutritional Index in Postoperative Infection Following Lobectomy in Non-Small Cell Lung Cancer Patients</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Background The prognostic nutritional index (PNI) is a valuable marker for evaluating the nutritional status associated with postoperative complications and the prognosis of patients with cancer. However, the role and clinical value of PNI in infection after lung cancer surgery remains unclear. This study examined the association between PNI and infection after lobectomy for lung cancer, focusing on the predictive value of PNI. Methods We conducted this retrospective cohort study on 139 patients with non-small cell lung cancer (NSCLC) who underwent surgery between September 2013 and December 2018. Two groups were composed according to their PNI values (≥ 50 or <50 ), and the relationship was assessed with infection after lobectomy. Results Only PNI values, atelectasis, and prolonged air leaks were significantly associated with the development of infection. The median preoperative PNI was 52.97±5.69. Postoperative infection was seen in patients (15.5%) with PNI≥ 50 and 38.1% in patients with PNI <50. The mean PNI in patients with postoperative infection, empyema, and prolonged air leakage was lower than in patients without these conditions. Conclusions Malnutrition is commonly seen in patients with malignancy. The overall malnutrition rate is 45% in lung cancer patients. Patients with metastatic diseases are malnourished in a 73% ratio compared to 5% for localized diseases. Furthermore, malnutrition increases the tendency of postoperative infection and reduces wound healing. We aim to determine whether PNI can be a predictive index marker for postoperative infection in patients with NSCLC who underwent lobectomy. Postoperative infection was seen in 15.5% of patients with PNI>50 and 38.1% in patients with PNI <50.</description><subject>Cardiac/Thoracic/Vascular Surgery</subject><subject>Disease</subject><subject>Dyspnea</subject><subject>Females</subject><subject>Hemoptysis</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Lung cancer</subject><subject>Lymphatic system</subject><subject>Lymphocytes</subject><subject>Malnutrition</subject><subject>Medical prognosis</subject><subject>Normal distribution</subject><subject>Ostomy</subject><subject>Pathology</subject><subject>Surgical techniques</subject><subject>Thoracic surgery</subject><subject>Wound healing</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkUFPGzEQha2qqCDKrefKUi89dOmMN157T1UVAUWKIBK5W47XDka7dmrv0nLrT8dpKKJcPNbM5zeeeYR8QDgVgrdfzZTslE9r0SC-IUcMG1lJlLO3L-6H5CTnOwBAEAwEvCOHtcBWYA1H5M_q1tIz56wZaXR0meImxDx6Q6-mMfnRx6B7ehk6-5v6QJelFrc26dHf25LevSsIPY99H3_5sKGLuC65ODzs8KsYqptB9z2d23IspgLMdTA20WWRsGHM78mB0322J0_xmKzOz1bzH9Xi-uJy_n1RmRpgrBrbGNFoxzvHEDoDs4ZxrusZIAJvpAHpOta2sgSNM-w06-xaSAetY-26Pibf9rLbaT3YzpTWSfdqm_yg04OK2qv_K8Hfqk28VwhlhbzFovD5SSHFn5PNoxp8NmUsHWycsmISOeMAghf00yv0Lk6pLHJHMWSNFDUU6sueMinmnKx7_g2C2rmr9u6qv-4W_OPLCZ7hf17Wj9rRous</recordid><startdate>20230415</startdate><enddate>20230415</enddate><creator>Hazer, Seray</creator><creator>Gülhan, Selim Şakir Erkmen</creator><creator>Solak, Necati</creator><creator>Yenibertiz, Derya</creator><creator>Akıllı, Mahmut Sami</creator><creator>Sayilir Guven, Ebru</creator><creator>Bıçakçıoğlu, Pınar</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230415</creationdate><title>The Effect of Prognostic Nutritional Index in Postoperative Infection Following Lobectomy in Non-Small Cell Lung Cancer Patients</title><author>Hazer, Seray ; Gülhan, Selim Şakir Erkmen ; Solak, Necati ; Yenibertiz, Derya ; Akıllı, Mahmut Sami ; Sayilir Guven, Ebru ; Bıçakçıoğlu, Pınar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c300t-6e6c76af5df210dc046255a340110568c08fd29988fda141da2deb78f09f29b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiac/Thoracic/Vascular Surgery</topic><topic>Disease</topic><topic>Dyspnea</topic><topic>Females</topic><topic>Hemoptysis</topic><topic>Hospitals</topic><topic>Infections</topic><topic>Lung cancer</topic><topic>Lymphatic system</topic><topic>Lymphocytes</topic><topic>Malnutrition</topic><topic>Medical prognosis</topic><topic>Normal distribution</topic><topic>Ostomy</topic><topic>Pathology</topic><topic>Surgical techniques</topic><topic>Thoracic surgery</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hazer, Seray</creatorcontrib><creatorcontrib>Gülhan, Selim Şakir Erkmen</creatorcontrib><creatorcontrib>Solak, Necati</creatorcontrib><creatorcontrib>Yenibertiz, Derya</creatorcontrib><creatorcontrib>Akıllı, Mahmut Sami</creatorcontrib><creatorcontrib>Sayilir Guven, Ebru</creatorcontrib><creatorcontrib>Bıçakçıoğlu, Pınar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hazer, Seray</au><au>Gülhan, Selim Şakir Erkmen</au><au>Solak, Necati</au><au>Yenibertiz, Derya</au><au>Akıllı, Mahmut Sami</au><au>Sayilir Guven, Ebru</au><au>Bıçakçıoğlu, Pınar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Prognostic Nutritional Index in Postoperative Infection Following Lobectomy in Non-Small Cell Lung Cancer Patients</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2023-04-15</date><risdate>2023</risdate><volume>15</volume><issue>4</issue><spage>e37611</spage><epage>e37611</epage><pages>e37611-e37611</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Background The prognostic nutritional index (PNI) is a valuable marker for evaluating the nutritional status associated with postoperative complications and the prognosis of patients with cancer. However, the role and clinical value of PNI in infection after lung cancer surgery remains unclear. This study examined the association between PNI and infection after lobectomy for lung cancer, focusing on the predictive value of PNI. Methods We conducted this retrospective cohort study on 139 patients with non-small cell lung cancer (NSCLC) who underwent surgery between September 2013 and December 2018. Two groups were composed according to their PNI values (≥ 50 or <50 ), and the relationship was assessed with infection after lobectomy. Results Only PNI values, atelectasis, and prolonged air leaks were significantly associated with the development of infection. The median preoperative PNI was 52.97±5.69. Postoperative infection was seen in patients (15.5%) with PNI≥ 50 and 38.1% in patients with PNI <50. The mean PNI in patients with postoperative infection, empyema, and prolonged air leakage was lower than in patients without these conditions. Conclusions Malnutrition is commonly seen in patients with malignancy. The overall malnutrition rate is 45% in lung cancer patients. Patients with metastatic diseases are malnourished in a 73% ratio compared to 5% for localized diseases. Furthermore, malnutrition increases the tendency of postoperative infection and reduces wound healing. We aim to determine whether PNI can be a predictive index marker for postoperative infection in patients with NSCLC who underwent lobectomy. Postoperative infection was seen in 15.5% of patients with PNI>50 and 38.1% in patients with PNI <50.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>37197130</pmid><doi>10.7759/cureus.37611</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Cardiac/Thoracic/Vascular Surgery Disease Dyspnea Females Hemoptysis Hospitals Infections Lung cancer Lymphatic system Lymphocytes Malnutrition Medical prognosis Normal distribution Ostomy Pathology Surgical techniques Thoracic surgery Wound healing |
| title | The Effect of Prognostic Nutritional Index in Postoperative Infection Following Lobectomy in Non-Small Cell Lung Cancer Patients |
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