Muscle oxygen utilization and ventilatory parameters during exercise in people with cystic fibrosis: Role of HbA1c
Introduction Glycated hemoglobin can interfere with oxygen delivery and CO2 removal during exercise. Additionally, pancreatic insufficiency increases oxidative stress and exacerbates exercise intolerance in people with cystic fibrosis (PwCF). This investigation sought to test the hypotheses that ele...
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creator | Quertermous, Brooke P Seigler, Nichole Looney, Jacob Crandall, Reva Simon, Abigayle B Blackburn, Marsha Derella, Cassandra C Blanks, Anson McKie, Kathleen T Forseen, Caralee Harris, Ryan A |
description | Introduction
Glycated hemoglobin can interfere with oxygen delivery and CO2 removal during exercise. Additionally, pancreatic insufficiency increases oxidative stress and exacerbates exercise intolerance in people with cystic fibrosis (PwCF). This investigation sought to test the hypotheses that elevated Hemoglobin A1c (HbA1c) can negatively affect exercise parameters in PwCF and that reductions in oxidative stress can improve tissue oxygenation in individuals with elevated HbA1c.
Methods
Twenty four PwCF were divided into two groups; normal HbA1c 5.7% (E-HbA1c). A maximal exercise test was conducted to obtain peak oxygen uptake (VO2peak), VO2 at ventilatory threshold (VT), ventilatory parameters (VE/VCO2 slope and end-tidal CO2 (petCO2)). Near-Infrared Spectroscopy (NIRS) was used to assess muscle oxygenated/deoxygenated hemoglobin during exercise. A subset of individuals with E-HbA1cwere given an antioxidant cocktail (AOC) for 4 weeks to determine the effects on tissue oxygenation during exercise.
Results
A negative relationship between HbA1c and VO2peak at VT was observed (r = −0.511; p = 0.018). In addition, a positive relationship between HbA1c and VE/VCO2 slope (r = 0.587;p = 0.005) and a negative relationship between HbA1c and petCO2 at maximal exercise (r = −0.472;p = 0.031) was observed. N-HbA1c had greater VO2peak (p = 0.021), VO2 at VT (p = 0.004), petCO2 (p = 0.002), and lower VE/VCO2 slope (p = 0.004) compared with E-HbA1c. Muscle deoxygenated hemoglobin at VT was higher in N-HbA1c vs. E-HbA1c and 4 weeks of AOC improved skeletal muscle utilization of oxygen.
Conclusion
Findings demonstrate that glycated hemoglobin may lead to tissue oxygenation impairment and ventilation inefficiency during exercise in PwCF. In addition, antioxidant supplementation may lead to improved tissue oxygenation during exercise. |
doi_str_mv | 10.1177/14799731231174542 |
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fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10184196</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_14799731231174542</sage_id><sourcerecordid>2812507710</sourcerecordid><originalsourceid>FETCH-LOGICAL-p2692-b12f465fee33820ddd8ba7c8ebc4a4b2ce2ec10358deffe53aa9d95f9d73df523</originalsourceid><addsrcrecordid>eNplUU1P3DAQtaqiAtv-gN4scellF3_EccwFIdQCEhUSomfLsceLUdYOdgJsfz2JFqmlPc3Mm6c38_QQ-krJilIpj2kllZKcMj6NlajYB3QwY8sZ_PhXv48OS3kghClZV5_QPpe0rrmoD1D-ORbbAU4v2zVEPA6hC7_NEFLEJjr8BHFCzJDyFvcmmw0MkAt2Yw5xjeEFsg0FcIi4h9RPOs9huMd2W4ZgsQ9tTiWUE3yb5hMeX7Zn1H5Ge950Bb681QX69eP73fnl8vrm4ur87HrZs1qxZUuZr2rhAThvGHHONa2RtoHWVqZqmQUGlhIuGgfeg-DGKKeEV05y5wXjC3S60-3HdgPOTlay6XSfw8bkrU4m6PebGO71Oj1pSmhTUVVPCt_eFHJ6HKEMehOKha4zEdJYNGsoE0TK6YsFOvqH-pDGHCd_milGGGmkmFmrHauYNfxhUKLnPPV_efJX9KqTxQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2920208750</pqid></control><display><type>article</type><title>Muscle oxygen utilization and ventilatory parameters during exercise in people with cystic fibrosis: Role of HbA1c</title><source>DOAJ Directory of Open Access Journals</source><source>Sage Journals GOLD Open Access 2024</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Quertermous, Brooke P ; Seigler, Nichole ; Looney, Jacob ; Crandall, Reva ; Simon, Abigayle B ; Blackburn, Marsha ; Derella, Cassandra C ; Blanks, Anson ; McKie, Kathleen T ; Forseen, Caralee ; Harris, Ryan A</creator><creatorcontrib>Quertermous, Brooke P ; Seigler, Nichole ; Looney, Jacob ; Crandall, Reva ; Simon, Abigayle B ; Blackburn, Marsha ; Derella, Cassandra C ; Blanks, Anson ; McKie, Kathleen T ; Forseen, Caralee ; Harris, Ryan A</creatorcontrib><description>Introduction
Glycated hemoglobin can interfere with oxygen delivery and CO2 removal during exercise. Additionally, pancreatic insufficiency increases oxidative stress and exacerbates exercise intolerance in people with cystic fibrosis (PwCF). This investigation sought to test the hypotheses that elevated Hemoglobin A1c (HbA1c) can negatively affect exercise parameters in PwCF and that reductions in oxidative stress can improve tissue oxygenation in individuals with elevated HbA1c.
Methods
Twenty four PwCF were divided into two groups; normal HbA1c <5.7% (N-HbA1c) and elevated HbA1c >5.7% (E-HbA1c). A maximal exercise test was conducted to obtain peak oxygen uptake (VO2peak), VO2 at ventilatory threshold (VT), ventilatory parameters (VE/VCO2 slope and end-tidal CO2 (petCO2)). Near-Infrared Spectroscopy (NIRS) was used to assess muscle oxygenated/deoxygenated hemoglobin during exercise. A subset of individuals with E-HbA1cwere given an antioxidant cocktail (AOC) for 4 weeks to determine the effects on tissue oxygenation during exercise.
Results
A negative relationship between HbA1c and VO2peak at VT was observed (r = −0.511; p = 0.018). In addition, a positive relationship between HbA1c and VE/VCO2 slope (r = 0.587;p = 0.005) and a negative relationship between HbA1c and petCO2 at maximal exercise (r = −0.472;p = 0.031) was observed. N-HbA1c had greater VO2peak (p = 0.021), VO2 at VT (p = 0.004), petCO2 (p = 0.002), and lower VE/VCO2 slope (p = 0.004) compared with E-HbA1c. Muscle deoxygenated hemoglobin at VT was higher in N-HbA1c vs. E-HbA1c and 4 weeks of AOC improved skeletal muscle utilization of oxygen.
Conclusion
Findings demonstrate that glycated hemoglobin may lead to tissue oxygenation impairment and ventilation inefficiency during exercise in PwCF. In addition, antioxidant supplementation may lead to improved tissue oxygenation during exercise.</description><identifier>ISSN: 1479-9731</identifier><identifier>ISSN: 1479-9723</identifier><identifier>EISSN: 1479-9731</identifier><identifier>DOI: 10.1177/14799731231174542</identifier><identifier>PMID: 37166356</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Chronic illnesses ; Cystic fibrosis ; Exercise ; Hemoglobin ; Original Paper ; Oxidative stress</subject><ispartof>Chronic respiratory disease, 2023-01, Vol.20, p.14799731231174542-14799731231174542</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023 2023 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-8826-681X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184196/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184196/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,21946,27832,27903,27904,44924,45312,53769,53771</link.rule.ids></links><search><creatorcontrib>Quertermous, Brooke P</creatorcontrib><creatorcontrib>Seigler, Nichole</creatorcontrib><creatorcontrib>Looney, Jacob</creatorcontrib><creatorcontrib>Crandall, Reva</creatorcontrib><creatorcontrib>Simon, Abigayle B</creatorcontrib><creatorcontrib>Blackburn, Marsha</creatorcontrib><creatorcontrib>Derella, Cassandra C</creatorcontrib><creatorcontrib>Blanks, Anson</creatorcontrib><creatorcontrib>McKie, Kathleen T</creatorcontrib><creatorcontrib>Forseen, Caralee</creatorcontrib><creatorcontrib>Harris, Ryan A</creatorcontrib><title>Muscle oxygen utilization and ventilatory parameters during exercise in people with cystic fibrosis: Role of HbA1c</title><title>Chronic respiratory disease</title><addtitle>Chron Respir Dis</addtitle><description>Introduction
Glycated hemoglobin can interfere with oxygen delivery and CO2 removal during exercise. Additionally, pancreatic insufficiency increases oxidative stress and exacerbates exercise intolerance in people with cystic fibrosis (PwCF). This investigation sought to test the hypotheses that elevated Hemoglobin A1c (HbA1c) can negatively affect exercise parameters in PwCF and that reductions in oxidative stress can improve tissue oxygenation in individuals with elevated HbA1c.
Methods
Twenty four PwCF were divided into two groups; normal HbA1c <5.7% (N-HbA1c) and elevated HbA1c >5.7% (E-HbA1c). A maximal exercise test was conducted to obtain peak oxygen uptake (VO2peak), VO2 at ventilatory threshold (VT), ventilatory parameters (VE/VCO2 slope and end-tidal CO2 (petCO2)). Near-Infrared Spectroscopy (NIRS) was used to assess muscle oxygenated/deoxygenated hemoglobin during exercise. A subset of individuals with E-HbA1cwere given an antioxidant cocktail (AOC) for 4 weeks to determine the effects on tissue oxygenation during exercise.
Results
A negative relationship between HbA1c and VO2peak at VT was observed (r = −0.511; p = 0.018). In addition, a positive relationship between HbA1c and VE/VCO2 slope (r = 0.587;p = 0.005) and a negative relationship between HbA1c and petCO2 at maximal exercise (r = −0.472;p = 0.031) was observed. N-HbA1c had greater VO2peak (p = 0.021), VO2 at VT (p = 0.004), petCO2 (p = 0.002), and lower VE/VCO2 slope (p = 0.004) compared with E-HbA1c. Muscle deoxygenated hemoglobin at VT was higher in N-HbA1c vs. E-HbA1c and 4 weeks of AOC improved skeletal muscle utilization of oxygen.
Conclusion
Findings demonstrate that glycated hemoglobin may lead to tissue oxygenation impairment and ventilation inefficiency during exercise in PwCF. In addition, antioxidant supplementation may lead to improved tissue oxygenation during exercise.</description><subject>Chronic illnesses</subject><subject>Cystic fibrosis</subject><subject>Exercise</subject><subject>Hemoglobin</subject><subject>Original Paper</subject><subject>Oxidative stress</subject><issn>1479-9731</issn><issn>1479-9723</issn><issn>1479-9731</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>BENPR</sourceid><recordid>eNplUU1P3DAQtaqiAtv-gN4scellF3_EccwFIdQCEhUSomfLsceLUdYOdgJsfz2JFqmlPc3Mm6c38_QQ-krJilIpj2kllZKcMj6NlajYB3QwY8sZ_PhXv48OS3kghClZV5_QPpe0rrmoD1D-ORbbAU4v2zVEPA6hC7_NEFLEJjr8BHFCzJDyFvcmmw0MkAt2Yw5xjeEFsg0FcIi4h9RPOs9huMd2W4ZgsQ9tTiWUE3yb5hMeX7Zn1H5Ge950Bb681QX69eP73fnl8vrm4ur87HrZs1qxZUuZr2rhAThvGHHONa2RtoHWVqZqmQUGlhIuGgfeg-DGKKeEV05y5wXjC3S60-3HdgPOTlay6XSfw8bkrU4m6PebGO71Oj1pSmhTUVVPCt_eFHJ6HKEMehOKha4zEdJYNGsoE0TK6YsFOvqH-pDGHCd_milGGGmkmFmrHauYNfxhUKLnPPV_efJX9KqTxQ</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Quertermous, Brooke P</creator><creator>Seigler, Nichole</creator><creator>Looney, Jacob</creator><creator>Crandall, Reva</creator><creator>Simon, Abigayle B</creator><creator>Blackburn, Marsha</creator><creator>Derella, Cassandra C</creator><creator>Blanks, Anson</creator><creator>McKie, Kathleen T</creator><creator>Forseen, Caralee</creator><creator>Harris, Ryan A</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8826-681X</orcidid></search><sort><creationdate>20230101</creationdate><title>Muscle oxygen utilization and ventilatory parameters during exercise in people with cystic fibrosis: Role of HbA1c</title><author>Quertermous, Brooke P ; Seigler, Nichole ; Looney, Jacob ; Crandall, Reva ; Simon, Abigayle B ; Blackburn, Marsha ; Derella, Cassandra C ; Blanks, Anson ; McKie, Kathleen T ; Forseen, Caralee ; Harris, Ryan A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2692-b12f465fee33820ddd8ba7c8ebc4a4b2ce2ec10358deffe53aa9d95f9d73df523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Chronic illnesses</topic><topic>Cystic fibrosis</topic><topic>Exercise</topic><topic>Hemoglobin</topic><topic>Original Paper</topic><topic>Oxidative stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quertermous, Brooke P</creatorcontrib><creatorcontrib>Seigler, Nichole</creatorcontrib><creatorcontrib>Looney, Jacob</creatorcontrib><creatorcontrib>Crandall, Reva</creatorcontrib><creatorcontrib>Simon, Abigayle B</creatorcontrib><creatorcontrib>Blackburn, Marsha</creatorcontrib><creatorcontrib>Derella, Cassandra C</creatorcontrib><creatorcontrib>Blanks, Anson</creatorcontrib><creatorcontrib>McKie, Kathleen T</creatorcontrib><creatorcontrib>Forseen, Caralee</creatorcontrib><creatorcontrib>Harris, Ryan A</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chronic respiratory disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quertermous, Brooke P</au><au>Seigler, Nichole</au><au>Looney, Jacob</au><au>Crandall, Reva</au><au>Simon, Abigayle B</au><au>Blackburn, Marsha</au><au>Derella, Cassandra C</au><au>Blanks, Anson</au><au>McKie, Kathleen T</au><au>Forseen, Caralee</au><au>Harris, Ryan A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Muscle oxygen utilization and ventilatory parameters during exercise in people with cystic fibrosis: Role of HbA1c</atitle><jtitle>Chronic respiratory disease</jtitle><addtitle>Chron Respir Dis</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>20</volume><spage>14799731231174542</spage><epage>14799731231174542</epage><pages>14799731231174542-14799731231174542</pages><issn>1479-9731</issn><issn>1479-9723</issn><eissn>1479-9731</eissn><abstract>Introduction
Glycated hemoglobin can interfere with oxygen delivery and CO2 removal during exercise. Additionally, pancreatic insufficiency increases oxidative stress and exacerbates exercise intolerance in people with cystic fibrosis (PwCF). This investigation sought to test the hypotheses that elevated Hemoglobin A1c (HbA1c) can negatively affect exercise parameters in PwCF and that reductions in oxidative stress can improve tissue oxygenation in individuals with elevated HbA1c.
Methods
Twenty four PwCF were divided into two groups; normal HbA1c <5.7% (N-HbA1c) and elevated HbA1c >5.7% (E-HbA1c). A maximal exercise test was conducted to obtain peak oxygen uptake (VO2peak), VO2 at ventilatory threshold (VT), ventilatory parameters (VE/VCO2 slope and end-tidal CO2 (petCO2)). Near-Infrared Spectroscopy (NIRS) was used to assess muscle oxygenated/deoxygenated hemoglobin during exercise. A subset of individuals with E-HbA1cwere given an antioxidant cocktail (AOC) for 4 weeks to determine the effects on tissue oxygenation during exercise.
Results
A negative relationship between HbA1c and VO2peak at VT was observed (r = −0.511; p = 0.018). In addition, a positive relationship between HbA1c and VE/VCO2 slope (r = 0.587;p = 0.005) and a negative relationship between HbA1c and petCO2 at maximal exercise (r = −0.472;p = 0.031) was observed. N-HbA1c had greater VO2peak (p = 0.021), VO2 at VT (p = 0.004), petCO2 (p = 0.002), and lower VE/VCO2 slope (p = 0.004) compared with E-HbA1c. Muscle deoxygenated hemoglobin at VT was higher in N-HbA1c vs. E-HbA1c and 4 weeks of AOC improved skeletal muscle utilization of oxygen.
Conclusion
Findings demonstrate that glycated hemoglobin may lead to tissue oxygenation impairment and ventilation inefficiency during exercise in PwCF. In addition, antioxidant supplementation may lead to improved tissue oxygenation during exercise.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>37166356</pmid><doi>10.1177/14799731231174542</doi><orcidid>https://orcid.org/0000-0002-8826-681X</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Chronic illnesses Cystic fibrosis Exercise Hemoglobin Original Paper Oxidative stress |
title | Muscle oxygen utilization and ventilatory parameters during exercise in people with cystic fibrosis: Role of HbA1c |
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