Lenalidomide Stabilizes Protein–Protein Complexes by Turning Labile Intermolecular H‑Bonds into Robust Interactions

Targeted protein degradation is a promising therapeutic strategy, spearheaded by the anti-myeloma drugs lenalidomide and pomalidomide. These drugs stabilize very efficiently the complex between the E3 ligase Cereblon (CRBN) and several non-native client proteins (neo-substrates), including the trans...

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Veröffentlicht in:	Journal of medicinal chemistry 2023-05, Vol.66 (9), p.6037-6046
Hauptverfasser:	Miñarro-Lleonar, Marina, Bertran-Mostazo, Andrea, Duro, Jorge, Barril, Xavier, Juárez-Jiménez, Jordi
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Lenalidomide - chemistry Lenalidomide - pharmacology Multiple Myeloma - drug therapy Peptide Hydrolases - metabolism Proteolysis Transcription Factors - metabolism Ubiquitin-Protein Ligases - metabolism
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