CircPVT1 promotes ER‐positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS

The molecular mechanisms underlying estrogen receptor (ER)‐positive breast carcinogenesis and endocrine therapy resistance remain incompletely understood. Here, we report that circPVT1, a circular RNA generated from the lncRNA PVT1, is highly expressed in ERα‐positive breast cancer cell lines and tu...

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Veröffentlicht in:	The EMBO journal 2023-05, Vol.42 (10), p.e112408-n/a
Hauptverfasser:	Yi, Jia, Wang, Lei, Hu, Guo‐sheng, Zhang, Yue‐ying, Du, Jiao, Ding, Jian‐cheng, Ji, Xiang, Shen, Hai‐feng, Huang, Hai‐hua, Ye, Feng, Liu, Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	anti‐tumor immunity Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinogenesis Carcinogenesis - genetics Carcinogens Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic - genetics circPVT1 Circular RNA Complex formation Drug resistance Drug Resistance, Neoplasm - genetics EMBO03 EMBO19 EMBO36 Endocrine therapy ERα Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Female Gene expression Gene Expression Regulation, Neoplastic Genes Humans Interferon Life Sciences Malignancy MAVS Molecular modelling mRNA Oligonucleotides Proteins Receptors Ribonucleic acid RNA RNA, Circular - genetics RNA, Circular - metabolism Scaffolding Sensitizing Signal transduction Tamoxifen Tamoxifen - pharmacology Tamoxifen - therapeutic use Therapeutic targets Therapy Tumor cell lines Tumorigenesis Tumors
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