Subendocardial Infarction in Severe Bicuspid Aortic Stenosis Without Coronary Stenosis Confirmed by Contrast-enhanced Computed Tomography and Autopsy
A 59-year-old man with aortic stenosis (AS) showed cardiopulmonary arrest requiring extracorporeal circulation. Although coronary angiography did not show coronary artery stenosis, he had an elevated creatine kinase-myocardial band value of 1,298 U/L. Echocardiography revealed severe AS and global h...
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Veröffentlicht in: | Internal Medicine 2022, pp.0109-22 |
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creator | Akiyama, Takumi Okoshi, Yuki Takano, Toshiki Yoshida, Tsuyoshi Tanabe, Yasuhiko Inomata, Takayuki |
description | A 59-year-old man with aortic stenosis (AS) showed cardiopulmonary arrest requiring extracorporeal circulation. Although coronary angiography did not show coronary artery stenosis, he had an elevated creatine kinase-myocardial band value of 1,298 U/L. Echocardiography revealed severe AS and global hypokinesia of the thickened myocardium. Contrast-enhanced computed tomography (CT) detected a circumferential subendocardial perfusion defect of the left ventricular myocardium. Eventually, the patient died from brain anoxia. Autopsy revealed circumferential subendocardial infarction of the left ventricular myocardium. This is the first case of circumferential subendocardial defect on CT corresponding to circumferential subendocardial infarction on autopsy in severe AS without coronary stenosis |
doi_str_mv | 10.2169/internalmedicine.0109-22 |
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Although coronary angiography did not show coronary artery stenosis, he had an elevated creatine kinase-myocardial band value of 1,298 U/L. Echocardiography revealed severe AS and global hypokinesia of the thickened myocardium. Contrast-enhanced computed tomography (CT) detected a circumferential subendocardial perfusion defect of the left ventricular myocardium. Eventually, the patient died from brain anoxia. Autopsy revealed circumferential subendocardial infarction of the left ventricular myocardium. This is the first case of circumferential subendocardial defect on CT corresponding to circumferential subendocardial infarction on autopsy in severe AS without coronary stenosis</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.0109-22</identifier><identifier>PMID: 36104194</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Angiography ; Anoxia ; Aortic stenosis ; Aortic valve stenosis ; Aortic Valve Stenosis - complications ; Aortic Valve Stenosis - diagnostic imaging ; Autopsy ; Case Report ; Computed tomography ; Coronary artery ; Coronary Stenosis - complications ; Coronary Stenosis - diagnostic imaging ; Creatine ; Creatine kinase ; Echocardiography ; Heart ; Humans ; Internal medicine ; Male ; Middle Aged ; myocardial infarction ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - etiology ; Myocardium ; Tomography, X-Ray Computed - methods ; Ventricle</subject><ispartof>Internal Medicine, 2022, pp.0109-22</ispartof><rights>2022 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2023</rights><rights>Copyright © 2023 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c620t-6f405a8568501bcd2fc61d29aa98086e24628e4c23a0c217151e3214643797d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183289/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183289/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,1877,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36104194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akiyama, Takumi</creatorcontrib><creatorcontrib>Okoshi, Yuki</creatorcontrib><creatorcontrib>Takano, Toshiki</creatorcontrib><creatorcontrib>Yoshida, Tsuyoshi</creatorcontrib><creatorcontrib>Tanabe, Yasuhiko</creatorcontrib><creatorcontrib>Inomata, Takayuki</creatorcontrib><title>Subendocardial Infarction in Severe Bicuspid Aortic Stenosis Without Coronary Stenosis Confirmed by Contrast-enhanced Computed Tomography and Autopsy</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 59-year-old man with aortic stenosis (AS) showed cardiopulmonary arrest requiring extracorporeal circulation. Although coronary angiography did not show coronary artery stenosis, he had an elevated creatine kinase-myocardial band value of 1,298 U/L. Echocardiography revealed severe AS and global hypokinesia of the thickened myocardium. Contrast-enhanced computed tomography (CT) detected a circumferential subendocardial perfusion defect of the left ventricular myocardium. Eventually, the patient died from brain anoxia. Autopsy revealed circumferential subendocardial infarction of the left ventricular myocardium. This is the first case of circumferential subendocardial defect on CT corresponding to circumferential subendocardial infarction on autopsy in severe AS without coronary stenosis</description><subject>Angiography</subject><subject>Anoxia</subject><subject>Aortic stenosis</subject><subject>Aortic valve stenosis</subject><subject>Aortic Valve Stenosis - complications</subject><subject>Aortic Valve Stenosis - diagnostic imaging</subject><subject>Autopsy</subject><subject>Case Report</subject><subject>Computed tomography</subject><subject>Coronary artery</subject><subject>Coronary Stenosis - complications</subject><subject>Coronary Stenosis - diagnostic imaging</subject><subject>Creatine</subject><subject>Creatine kinase</subject><subject>Echocardiography</subject><subject>Heart</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>myocardial infarction</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - etiology</subject><subject>Myocardium</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Ventricle</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkctu1DAUhiMEokPhFZAlNmxSfMnFXqESFahUicUUWFoe52TiUWIH2xlpHoT3xdGUAGXj63f-8x_9WYYIvqKkEu-MjeCtGkZojTYWrjDBIqf0SbYhrBB5TVn5NNtgQXhO03KRvQjhgDHjtaDPswtWEVwQUWyyn9t5B7Z1WvnWqAHd2k55HY2zyFi0hSN4QB-MnsNkWnTtfDQabSNYF0xA303s3RxR47yzyp_-_DTOdsYnf2h3Wi7RqxBzsL2yOj02bpzmmA73bnR7r6b-hJRNDebopnB6mT3r1BDg1cN-mX39eHPffM7vvny6ba7vcl1RHPOqK3CpeFnxEpOdbmmnK9JSoZTgmFdAi4pyKDRlCmtKalISYJQUVcFqUbcVu8zen3WneZe8alh8DnLyZkzTSKeM_PfHml7u3VESTDijXCSFtw8K3v2YIUQ5mqBhGJQFNwdJ69SuLDnHCX3zCD24eUkxUTzFlhi8WOJnSnsXgodudUOwXMKXj8OXS_iS0lT6-u9p1sLfaSfg2xk4hKj2sAJqSXWA_5VVe0xaEq-Hc6e1QPfKS7DsF-nG1I0</recordid><startdate>20230415</startdate><enddate>20230415</enddate><creator>Akiyama, Takumi</creator><creator>Okoshi, Yuki</creator><creator>Takano, Toshiki</creator><creator>Yoshida, Tsuyoshi</creator><creator>Tanabe, Yasuhiko</creator><creator>Inomata, Takayuki</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230415</creationdate><title>Subendocardial Infarction in Severe Bicuspid Aortic Stenosis Without Coronary Stenosis Confirmed by Contrast-enhanced Computed Tomography and Autopsy</title><author>Akiyama, Takumi ; Okoshi, Yuki ; Takano, Toshiki ; Yoshida, Tsuyoshi ; Tanabe, Yasuhiko ; Inomata, Takayuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-6f405a8568501bcd2fc61d29aa98086e24628e4c23a0c217151e3214643797d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Angiography</topic><topic>Anoxia</topic><topic>Aortic stenosis</topic><topic>Aortic valve stenosis</topic><topic>Aortic Valve Stenosis - complications</topic><topic>Aortic Valve Stenosis - diagnostic imaging</topic><topic>Autopsy</topic><topic>Case Report</topic><topic>Computed tomography</topic><topic>Coronary artery</topic><topic>Coronary Stenosis - complications</topic><topic>Coronary Stenosis - diagnostic imaging</topic><topic>Creatine</topic><topic>Creatine kinase</topic><topic>Echocardiography</topic><topic>Heart</topic><topic>Humans</topic><topic>Internal medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>myocardial infarction</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - etiology</topic><topic>Myocardium</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akiyama, Takumi</creatorcontrib><creatorcontrib>Okoshi, Yuki</creatorcontrib><creatorcontrib>Takano, Toshiki</creatorcontrib><creatorcontrib>Yoshida, Tsuyoshi</creatorcontrib><creatorcontrib>Tanabe, Yasuhiko</creatorcontrib><creatorcontrib>Inomata, Takayuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akiyama, Takumi</au><au>Okoshi, Yuki</au><au>Takano, Toshiki</au><au>Yoshida, Tsuyoshi</au><au>Tanabe, Yasuhiko</au><au>Inomata, Takayuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subendocardial Infarction in Severe Bicuspid Aortic Stenosis Without Coronary Stenosis Confirmed by Contrast-enhanced Computed Tomography and Autopsy</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2023-04-15</date><risdate>2023</risdate><volume>62</volume><issue>8</issue><spage>0109-22</spage><epage>1183</epage><pages>0109-22-1183</pages><artnum>0109-22</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 59-year-old man with aortic stenosis (AS) showed cardiopulmonary arrest requiring extracorporeal circulation. Although coronary angiography did not show coronary artery stenosis, he had an elevated creatine kinase-myocardial band value of 1,298 U/L. Echocardiography revealed severe AS and global hypokinesia of the thickened myocardium. Contrast-enhanced computed tomography (CT) detected a circumferential subendocardial perfusion defect of the left ventricular myocardium. Eventually, the patient died from brain anoxia. Autopsy revealed circumferential subendocardial infarction of the left ventricular myocardium. This is the first case of circumferential subendocardial defect on CT corresponding to circumferential subendocardial infarction on autopsy in severe AS without coronary stenosis</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>36104194</pmid><doi>10.2169/internalmedicine.0109-22</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Angiography Anoxia Aortic stenosis Aortic valve stenosis Aortic Valve Stenosis - complications Aortic Valve Stenosis - diagnostic imaging Autopsy Case Report Computed tomography Coronary artery Coronary Stenosis - complications Coronary Stenosis - diagnostic imaging Creatine Creatine kinase Echocardiography Heart Humans Internal medicine Male Middle Aged myocardial infarction Myocardial Infarction - diagnostic imaging Myocardial Infarction - etiology Myocardium Tomography, X-Ray Computed - methods Ventricle |
title | Subendocardial Infarction in Severe Bicuspid Aortic Stenosis Without Coronary Stenosis Confirmed by Contrast-enhanced Computed Tomography and Autopsy |
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