Endoplasmic reticulum protein 5 attenuates platelet endoplasmic reticulum stress and secretion in a mouse model

•ERp5 inhibits the activation of ER stress sensors protein kinase RNA-like endoplasmic reticulum kinase and IRE1 in murine platelets.•In ERp5-deficient platelets, defective ER homeostasis promotes secretion of ER PDIs and chaperones. [Display omitted] Extracellular protein disulfide isomerases (PDIs...

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Veröffentlicht in:	Blood advances 2023-05, Vol.7 (9), p.1650-1665
Hauptverfasser:	Lay, Angelina J., Dupuy, Alexander, Hagimola, Lejla, Tieng, Jessica, Larance, Mark, Zhang, Yunwei, Yang, Jean, Kong, Yvonne, Chiu, Joyce, Gray, Emilia, Qin, Zihao, Schmidt, Diana, Maclean, Jessica, Hofma, Benjamin, Ellis, Marc, Kalev-Zylinska, Maggie, Argon, Yair, Jackson, Shaun P., Hogg, Philip, Passam, Freda H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Platelets - metabolism Hemostasis Mice Platelet Aggregation Platelets and Thrombopoiesis Protein Disulfide-Isomerases - genetics Protein Disulfide-Isomerases - metabolism Thrombosis - metabolism
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