Rational Design of Daunorubicin C-14 Hydroxylase Based on the Understanding of Its Substrate-Binding Mechanism

Doxorubicin is one of the most widely used antitumor drugs and is currently produced via the chemical conversion method, which suffers from high production costs, complex product separation processes, and serious environmental pollution. Biocatalysis is considered a more efficient and environment-fr...

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Veröffentlicht in:	International journal of molecular sciences 2023-05, Vol.24 (9), p.8337
Hauptverfasser:	Zhang, Jing, Gao, Ling-Xiao, Chen, Wei, Zhong, Jian-Jiang, Qian, Chao, Zhou, Wen-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Binding Bioconversion Biosynthesis By products Cancer Catalysis Catalytic activity Cytochrome Cytochrome P-450 Enzyme System - metabolism Daunorubicin Daunorubicin - metabolism Doxorubicin Doxorubicin - chemistry E coli Efficiency Enzymatic activity Enzyme activity Enzymes Escherichia coli Genes Hydrophobicity Ligands Molecular docking Molecular Docking Simulation Molecular dynamics Mutants Oxidation Protein Conformation Protein structure Proteins Simulation
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