Polypharmacy Management in a Gender Perspective: At the Heart of the Problem: Analysis of Major Cardiac Diseases, SARS-CoV-2 Affection and Gender Distribution in a Cohort of Patients in Internal Medicine Ward
COVID-19 patients with any pre-existing major cardio-vascular disease (CVD) are at the highest risk of viral infection and of developing severe disease. The pathophysiological mechanism is characterized by the viral link to angiotensin-converting enzyme 2 (ACE2) and the involvement of the endothelia...
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| Veröffentlicht in: | International journal of environmental research and public health 2023-05, Vol.20 (9), p.5711 |
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| creator | Pietrantonio, Filomena Ciamei, Angela Vinci, Antonio Ciarambino, Tiziana Alessi, Elena Pascucci, Matteo Delli Castelli, Michela Zito, Silvia Sanguedolce, Simona Rainone, Marianna Di Lorenzo, Jacopo Vinci, Fabio Laurelli, Giulia Di Iorio, Claudia Corsi, Roberto Ricci, Serafino Di Berardino, Alessandra Ruggeri, Matteo Rosiello, Francesco |
| description | COVID-19 patients with any pre-existing major cardio-vascular disease (CVD) are at the highest risk of viral infection and of developing severe disease. The pathophysiological mechanism is characterized by the viral link to angiotensin-converting enzyme 2 (ACE2) and the involvement of the endothelial system with the release of cytokines and the inflicting of direct damage to the myocardium, the induction of microthrombosis, and the initiation of alterations in oxygen diffusion. The aim of the study is to analyze the clinical course and outcomes in patients (gender-stratified) with pre-existing major CVD.
Out of the 1833 (973 M/860 F) patients admitted to the Internal Medicine COVID-19 Unit of "Castelli Hospital", Lazio, Italy, from 1 January 2021 to 31 December 2021, 600 patients (320 M/280 F) with a mean age of 77 (78.6 M/75.1 F) previously had CVD. Demographic characteristics, length of the stay (LOS) and oxygen therapy were evaluated.
All of the CVD COVID-19 patients underwent non-invasive ventilation (NIV). CVD was linked with increased LOS (21 days F/22 M) compared to no CVD (19 days). In total, 32.7% of total patients had major CVD.
Timely identification and evaluation of patients with pre-existing major CVD are fundamental for adequate treatment based on gender, severity, state of illness and for risk reduction. |
| doi_str_mv | 10.3390/ijerph20095711 |
| format | Article |
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Out of the 1833 (973 M/860 F) patients admitted to the Internal Medicine COVID-19 Unit of "Castelli Hospital", Lazio, Italy, from 1 January 2021 to 31 December 2021, 600 patients (320 M/280 F) with a mean age of 77 (78.6 M/75.1 F) previously had CVD. Demographic characteristics, length of the stay (LOS) and oxygen therapy were evaluated.
All of the CVD COVID-19 patients underwent non-invasive ventilation (NIV). CVD was linked with increased LOS (21 days F/22 M) compared to no CVD (19 days). In total, 32.7% of total patients had major CVD.
Timely identification and evaluation of patients with pre-existing major CVD are fundamental for adequate treatment based on gender, severity, state of illness and for risk reduction.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph20095711</identifier><identifier>PMID: 37174229</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>ACE2 ; Aged ; Analysis ; Angiotensin ; Angiotensin-converting enzyme 2 ; Blood circulation disorders ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Coronary artery disease ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; Cytokines ; Development and progression ; Diabetes ; Disease transmission ; Enzymes ; Fatalities ; Gender ; Health aspects ; Health risks ; Heart attacks ; Heart diseases ; Heart Diseases - epidemiology ; Heart failure ; Hospitalization ; Hospitals ; Humans ; Hypertension ; Infections ; Intensive care ; Internal medicine ; Lungs ; Medicine ; Myocardium ; Oxygen ; Pandemics ; Patients ; Peptidyl-dipeptidase A ; Pneumonia ; Polypharmacy ; Risk management ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Vascular diseases ; Virus diseases ; Womens health</subject><ispartof>International journal of environmental research and public health, 2023-05, Vol.20 (9), p.5711</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4011-c0fb8de71559cf3933de69c3cdf27d87b4efb1b20d88f1b555713302a64fb0693</citedby><cites>FETCH-LOGICAL-c4011-c0fb8de71559cf3933de69c3cdf27d87b4efb1b20d88f1b555713302a64fb0693</cites><orcidid>0000-0002-6532-1185 ; 0000-0003-1119-0869 ; 0000-0002-4915-7733 ; 0000-0002-3917-1478</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178862/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10178862/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37174229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pietrantonio, Filomena</creatorcontrib><creatorcontrib>Ciamei, Angela</creatorcontrib><creatorcontrib>Vinci, Antonio</creatorcontrib><creatorcontrib>Ciarambino, Tiziana</creatorcontrib><creatorcontrib>Alessi, Elena</creatorcontrib><creatorcontrib>Pascucci, Matteo</creatorcontrib><creatorcontrib>Delli Castelli, Michela</creatorcontrib><creatorcontrib>Zito, Silvia</creatorcontrib><creatorcontrib>Sanguedolce, Simona</creatorcontrib><creatorcontrib>Rainone, Marianna</creatorcontrib><creatorcontrib>Di Lorenzo, Jacopo</creatorcontrib><creatorcontrib>Vinci, Fabio</creatorcontrib><creatorcontrib>Laurelli, Giulia</creatorcontrib><creatorcontrib>Di Iorio, Claudia</creatorcontrib><creatorcontrib>Corsi, Roberto</creatorcontrib><creatorcontrib>Ricci, Serafino</creatorcontrib><creatorcontrib>Di Berardino, Alessandra</creatorcontrib><creatorcontrib>Ruggeri, Matteo</creatorcontrib><creatorcontrib>Rosiello, Francesco</creatorcontrib><title>Polypharmacy Management in a Gender Perspective: At the Heart of the Problem: Analysis of Major Cardiac Diseases, SARS-CoV-2 Affection and Gender Distribution in a Cohort of Patients in Internal Medicine Ward</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>COVID-19 patients with any pre-existing major cardio-vascular disease (CVD) are at the highest risk of viral infection and of developing severe disease. The pathophysiological mechanism is characterized by the viral link to angiotensin-converting enzyme 2 (ACE2) and the involvement of the endothelial system with the release of cytokines and the inflicting of direct damage to the myocardium, the induction of microthrombosis, and the initiation of alterations in oxygen diffusion. The aim of the study is to analyze the clinical course and outcomes in patients (gender-stratified) with pre-existing major CVD.
Out of the 1833 (973 M/860 F) patients admitted to the Internal Medicine COVID-19 Unit of "Castelli Hospital", Lazio, Italy, from 1 January 2021 to 31 December 2021, 600 patients (320 M/280 F) with a mean age of 77 (78.6 M/75.1 F) previously had CVD. Demographic characteristics, length of the stay (LOS) and oxygen therapy were evaluated.
All of the CVD COVID-19 patients underwent non-invasive ventilation (NIV). CVD was linked with increased LOS (21 days F/22 M) compared to no CVD (19 days). In total, 32.7% of total patients had major CVD.
Timely identification and evaluation of patients with pre-existing major CVD are fundamental for adequate treatment based on gender, severity, state of illness and for risk reduction.</description><subject>ACE2</subject><subject>Aged</subject><subject>Analysis</subject><subject>Angiotensin</subject><subject>Angiotensin-converting enzyme 2</subject><subject>Blood circulation disorders</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Coronary artery disease</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - epidemiology</subject><subject>Cytokines</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Disease transmission</subject><subject>Enzymes</subject><subject>Fatalities</subject><subject>Gender</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Heart Diseases - 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The pathophysiological mechanism is characterized by the viral link to angiotensin-converting enzyme 2 (ACE2) and the involvement of the endothelial system with the release of cytokines and the inflicting of direct damage to the myocardium, the induction of microthrombosis, and the initiation of alterations in oxygen diffusion. The aim of the study is to analyze the clinical course and outcomes in patients (gender-stratified) with pre-existing major CVD.
Out of the 1833 (973 M/860 F) patients admitted to the Internal Medicine COVID-19 Unit of "Castelli Hospital", Lazio, Italy, from 1 January 2021 to 31 December 2021, 600 patients (320 M/280 F) with a mean age of 77 (78.6 M/75.1 F) previously had CVD. Demographic characteristics, length of the stay (LOS) and oxygen therapy were evaluated.
All of the CVD COVID-19 patients underwent non-invasive ventilation (NIV). CVD was linked with increased LOS (21 days F/22 M) compared to no CVD (19 days). In total, 32.7% of total patients had major CVD.
Timely identification and evaluation of patients with pre-existing major CVD are fundamental for adequate treatment based on gender, severity, state of illness and for risk reduction.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37174229</pmid><doi>10.3390/ijerph20095711</doi><orcidid>https://orcid.org/0000-0002-6532-1185</orcidid><orcidid>https://orcid.org/0000-0003-1119-0869</orcidid><orcidid>https://orcid.org/0000-0002-4915-7733</orcidid><orcidid>https://orcid.org/0000-0002-3917-1478</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1660-4601 |
| ispartof | International journal of environmental research and public health, 2023-05, Vol.20 (9), p.5711 |
| issn | 1660-4601 1661-7827 1660-4601 |
| language | eng |
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| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | ACE2 Aged Analysis Angiotensin Angiotensin-converting enzyme 2 Blood circulation disorders Cardiovascular disease Chronic obstructive pulmonary disease Coronary artery disease Coronaviruses COVID-19 COVID-19 - epidemiology Cytokines Development and progression Diabetes Disease transmission Enzymes Fatalities Gender Health aspects Health risks Heart attacks Heart diseases Heart Diseases - epidemiology Heart failure Hospitalization Hospitals Humans Hypertension Infections Intensive care Internal medicine Lungs Medicine Myocardium Oxygen Pandemics Patients Peptidyl-dipeptidase A Pneumonia Polypharmacy Risk management SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Vascular diseases Virus diseases Womens health |
| title | Polypharmacy Management in a Gender Perspective: At the Heart of the Problem: Analysis of Major Cardiac Diseases, SARS-CoV-2 Affection and Gender Distribution in a Cohort of Patients in Internal Medicine Ward |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T09%3A52%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Polypharmacy%20Management%20in%20a%20Gender%20Perspective:%20At%20the%20Heart%20of%20the%20Problem:%20Analysis%20of%20Major%20Cardiac%20Diseases,%20SARS-CoV-2%20Affection%20and%20Gender%20Distribution%20in%20a%20Cohort%20of%20Patients%20in%20Internal%20Medicine%20Ward&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Pietrantonio,%20Filomena&rft.date=2023-05-03&rft.volume=20&rft.issue=9&rft.spage=5711&rft.pages=5711-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph20095711&rft_dat=%3Cgale_pubme%3EA752360520%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2812407034&rft_id=info:pmid/37174229&rft_galeid=A752360520&rfr_iscdi=true |