Perfluorocarbon Nanoemulsions with Fluorous Chlorin-Type Photosensitizers for Antitumor Photodynamic Therapy in Hypoxia

The efficacy of photodynamic therapy (PDT) strictly depends on the availability of molecular oxygen to trigger the light-induced generation of reactive species. Fluorocarbons have an increased ability to dissolve oxygen and are attractive tools for gas delivery. We synthesized three fluorous derivat...

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Veröffentlicht in:	International journal of molecular sciences 2023-04, Vol.24 (9), p.7995
Hauptverfasser:	Nguyen, Minh Tuan, Guseva, Elizaveta V, Ataeva, Aida N, Sigan, Andrey L, Shibaeva, Anna V, Dmitrieva, Maria V, Burtsev, Ivan D, Volodina, Yulia L, Radchenko, Alexandra S, Egorov, Anton E, Kostyukov, Alexey A, Melnikov, Pavel V, Chkanikov, Nikolai D, Kuzmin, Vladimir A, Shtil, Alexander A, Markova, Alina A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal behavior Biocompatibility Cancer Catalysis Cell Line, Tumor Colorectal cancer Cytotoxicity Emulsions - chemistry Fluorine Fluorocarbons Fluorocarbons - pharmacology Formulations Humans Hydrophobicity Hypoxia Hypoxia - metabolism Iodine Lipid peroxidation Lipids Mitochondria Nanoemulsions Nanoparticles Oxygen Oxygen depletion Perfluorocarbons Perfluorodecalin Peroxidation Photochemotherapy Photodynamic therapy Photosensitization Photosensitizing Agents - chemistry Porphyrins - chemistry Singlet oxygen Solvents Spectrum analysis Sulfite Sulfites
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