High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway

Nicotinamide mononucleotide (NMN) is the physiological circulating NAD precursor thought to elevate the cellular level of NAD and to ameliorate various age-related diseases. An inseparable link exists between aging and tumorigenesis, especially involving aberrant energetic metabolism and cell fate r...

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Veröffentlicht in:	Cancers 2023-04, Vol.15 (9), p.2427
Hauptverfasser:	Zhang, Mingjiong, Cui, Jiahua, Chen, Haoyan, Wang, Yu, Kuai, Xingwang, Sun, Sibo, Tang, Qi, Zong, Feng, Chen, Qiaoyu, Wu, Jianqing, Wu, Shuangshuang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Aging Alzheimer's disease Animal models Apoptosis Cancer Cell culture Cell fate Cell growth Cell proliferation Drug dosages Enzyme-linked immunosorbent assay Ferroptosis Flow cytometry Growth Immunofluorescence Infections Intracellular Laboratory animals Lung cancer Lungs Metabolism Metabolites NAD Niacinamide Nicotinamide phosphoribosyltransferase Oncology, Experimental Phosphoribosyltransferase Plasmids Proteins SIRT1 protein Transmission electron microscopy Tumorigenesis Tumors
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