Ineffective cellular immune response associated with T-cell apoptosis in susceptible Mycobacterium bovis BCG-infected mice

It has previously been reported that inhibition of delayed-type hypersensitivity-mediating functions of T cells during mycobacterial infection in mice is haplotype dependent. In the present study, we show that Mycobacterium bovis BCG infection induced, in susceptible C57BL/6 and BALB/c mice but not...

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Veröffentlicht in:	Infection and immunity 2000-07, Vol.68 (7), p.4264-4273
Hauptverfasser:	KREMER, L, ESTAQUIER, J, WOLOWCZUK, I, BIET, F, AMEISEN, J.-C, LOCHT, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - immunology Bacterial diseases Bacterial Infections Base Sequence Biological and medical sciences DNA Primers - genetics Experimental bacterial diseases and models Fas Ligand Protein fas Receptor - metabolism Gene Expression Immunity, Cellular Infectious diseases Liver - immunology Liver - pathology Lymphocyte Activation Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred DBA Mycobacterium bovis RNA, Messenger - genetics RNA, Messenger - metabolism Species Specificity Spleen - immunology Spleen - pathology Splenomegaly - etiology Splenomegaly - immunology Splenomegaly - pathology T-Lymphocytes - immunology T-Lymphocytes - pathology Tuberculosis - genetics Tuberculosis - immunology Tuberculosis - pathology Tumor Necrosis Factor-alpha - biosynthesis
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