Transient Premature Ovarian Insufficiency Post-COVID-19 Infection
Anti-ovarian antibodies (AOAs) have been linked to autoimmune premature ovarian insufficiency (POI). This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral contraceptives and subsequent high-dose oral...
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| Veröffentlicht in: | Curēus (Palo Alto, CA) CA), 2023-04, Vol.15 (4), p.e37379 |
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| creator | Gorman, Colleen N Abdalla, Tori E Sultan, Yasmina Grabois, Spencer A Wood, Ellen G |
| description | Anti-ovarian antibodies (AOAs) have been linked to autoimmune premature ovarian insufficiency (POI). This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral contraceptives and subsequent high-dose oral corticosteroids, the patient underwent fertility treatment with in vitro fertilization (IVF). A total of 23 oocytes were retrieved. Two euploid blastocysts and three untested blastocysts were successfully created. This report hypothesizes the connection between autoimmune POI, AOA, and COVID-19. Conflicting data have been reported linking COVID-19 and ovarian injury. However, it is suggested that COVID-19 transiently impacts the menstrual cycle and anti-Mullerian hormone (AMH) levels. Treatment to overcome poor ovarian response due to AOA has not been adequately determined; however, similar autoimmune conditions have been successfully treated with corticosteroids. |
| doi_str_mv | 10.7759/cureus.37379 |
| format | Article |
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This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral contraceptives and subsequent high-dose oral corticosteroids, the patient underwent fertility treatment with in vitro fertilization (IVF). A total of 23 oocytes were retrieved. Two euploid blastocysts and three untested blastocysts were successfully created. This report hypothesizes the connection between autoimmune POI, AOA, and COVID-19. Conflicting data have been reported linking COVID-19 and ovarian injury. However, it is suggested that COVID-19 transiently impacts the menstrual cycle and anti-Mullerian hormone (AMH) levels. Treatment to overcome poor ovarian response due to AOA has not been adequately determined; however, similar autoimmune conditions have been successfully treated with corticosteroids.</description><identifier>ISSN: 2168-8184</identifier><identifier>EISSN: 2168-8184</identifier><identifier>DOI: 10.7759/cureus.37379</identifier><identifier>PMID: 37182044</identifier><language>eng</language><publisher>United States: Cureus Inc</publisher><subject>Allergy/Immunology ; Antibodies ; Birth control ; Coronaviruses ; COVID-19 vaccines ; Enzymes ; Fertility ; In vitro fertilization ; Infections ; Infectious Disease ; Infertility ; Menstruation ; Morphology ; Motility ; Obstetrics/Gynecology ; Ovaries ; Pandemics ; Reproductive technologies ; Sperm ; Ultrasonic imaging ; Uterus</subject><ispartof>Curēus (Palo Alto, CA), 2023-04, Vol.15 (4), p.e37379</ispartof><rights>Copyright © 2023, Gorman et al.</rights><rights>Copyright © 2023, Gorman et al. This work is published under https://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023, Gorman et al. 2023 Gorman et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c267t-4e12d00135c3cb70420b2f1772009fbe2815001270ca8897b89ed4bb9ad9774c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171879/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10171879/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37182044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gorman, Colleen N</creatorcontrib><creatorcontrib>Abdalla, Tori E</creatorcontrib><creatorcontrib>Sultan, Yasmina</creatorcontrib><creatorcontrib>Grabois, Spencer A</creatorcontrib><creatorcontrib>Wood, Ellen G</creatorcontrib><title>Transient Premature Ovarian Insufficiency Post-COVID-19 Infection</title><title>Curēus (Palo Alto, CA)</title><addtitle>Cureus</addtitle><description>Anti-ovarian antibodies (AOAs) have been linked to autoimmune premature ovarian insufficiency (POI). This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral contraceptives and subsequent high-dose oral corticosteroids, the patient underwent fertility treatment with in vitro fertilization (IVF). A total of 23 oocytes were retrieved. Two euploid blastocysts and three untested blastocysts were successfully created. This report hypothesizes the connection between autoimmune POI, AOA, and COVID-19. Conflicting data have been reported linking COVID-19 and ovarian injury. However, it is suggested that COVID-19 transiently impacts the menstrual cycle and anti-Mullerian hormone (AMH) levels. Treatment to overcome poor ovarian response due to AOA has not been adequately determined; however, similar autoimmune conditions have been successfully treated with corticosteroids.</description><subject>Allergy/Immunology</subject><subject>Antibodies</subject><subject>Birth control</subject><subject>Coronaviruses</subject><subject>COVID-19 vaccines</subject><subject>Enzymes</subject><subject>Fertility</subject><subject>In vitro fertilization</subject><subject>Infections</subject><subject>Infectious Disease</subject><subject>Infertility</subject><subject>Menstruation</subject><subject>Morphology</subject><subject>Motility</subject><subject>Obstetrics/Gynecology</subject><subject>Ovaries</subject><subject>Pandemics</subject><subject>Reproductive technologies</subject><subject>Sperm</subject><subject>Ultrasonic imaging</subject><subject>Uterus</subject><issn>2168-8184</issn><issn>2168-8184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVkM1PAjEQxRujEYLcPJtNvLrYr2XakyH4RUICB_TadLtdXQJdbHdJ-O-tggRPM8l7efObh9A1wQOATN6b1ts2DBgwkGeoS8lQpIIIfn6yd1A_hCXGmGCgGPAl6jAggmLOu2i08NqFyrommXu71k0MTGZb7SvtkokLbVlWJspml8zr0KTj2fvkMSUyaqU1TVW7K3RR6lWw_cPsobfnp8X4NZ3OXibj0TQ1dAhNyi2hRWRgmWEmB8wpzmlJICJhWeaWCpJFmQI2WggJuZC24HkudSEBuGE99LDP3bT52hYmInu9UhtfrbXfqVpX6r_iqk_1UW8VwSS-CzIm3B4SfP3V2tCoZd16F6EVFZTQIc8Yia67vcv4OgRvy-MJgtVP6WpfuvotPdpvTrGO5r-K2TdZKX03</recordid><startdate>20230410</startdate><enddate>20230410</enddate><creator>Gorman, Colleen N</creator><creator>Abdalla, Tori E</creator><creator>Sultan, Yasmina</creator><creator>Grabois, Spencer A</creator><creator>Wood, Ellen G</creator><general>Cureus Inc</general><general>Cureus</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20230410</creationdate><title>Transient Premature Ovarian Insufficiency Post-COVID-19 Infection</title><author>Gorman, Colleen N ; Abdalla, Tori E ; Sultan, Yasmina ; Grabois, Spencer A ; Wood, Ellen G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-4e12d00135c3cb70420b2f1772009fbe2815001270ca8897b89ed4bb9ad9774c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allergy/Immunology</topic><topic>Antibodies</topic><topic>Birth control</topic><topic>Coronaviruses</topic><topic>COVID-19 vaccines</topic><topic>Enzymes</topic><topic>Fertility</topic><topic>In vitro fertilization</topic><topic>Infections</topic><topic>Infectious Disease</topic><topic>Infertility</topic><topic>Menstruation</topic><topic>Morphology</topic><topic>Motility</topic><topic>Obstetrics/Gynecology</topic><topic>Ovaries</topic><topic>Pandemics</topic><topic>Reproductive technologies</topic><topic>Sperm</topic><topic>Ultrasonic imaging</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gorman, Colleen N</creatorcontrib><creatorcontrib>Abdalla, Tori E</creatorcontrib><creatorcontrib>Sultan, Yasmina</creatorcontrib><creatorcontrib>Grabois, Spencer A</creatorcontrib><creatorcontrib>Wood, Ellen G</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Curēus (Palo Alto, CA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gorman, Colleen N</au><au>Abdalla, Tori E</au><au>Sultan, Yasmina</au><au>Grabois, Spencer A</au><au>Wood, Ellen G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transient Premature Ovarian Insufficiency Post-COVID-19 Infection</atitle><jtitle>Curēus (Palo Alto, CA)</jtitle><addtitle>Cureus</addtitle><date>2023-04-10</date><risdate>2023</risdate><volume>15</volume><issue>4</issue><spage>e37379</spage><pages>e37379-</pages><issn>2168-8184</issn><eissn>2168-8184</eissn><abstract>Anti-ovarian antibodies (AOAs) have been linked to autoimmune premature ovarian insufficiency (POI). This report details a case in which a patient experienced transient POI after a COVID-19 infection and tested positive for AOA. After treatment with oral contraceptives and subsequent high-dose oral corticosteroids, the patient underwent fertility treatment with in vitro fertilization (IVF). A total of 23 oocytes were retrieved. Two euploid blastocysts and three untested blastocysts were successfully created. This report hypothesizes the connection between autoimmune POI, AOA, and COVID-19. Conflicting data have been reported linking COVID-19 and ovarian injury. However, it is suggested that COVID-19 transiently impacts the menstrual cycle and anti-Mullerian hormone (AMH) levels. Treatment to overcome poor ovarian response due to AOA has not been adequately determined; however, similar autoimmune conditions have been successfully treated with corticosteroids.</abstract><cop>United States</cop><pub>Cureus Inc</pub><pmid>37182044</pmid><doi>10.7759/cureus.37379</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Allergy/Immunology Antibodies Birth control Coronaviruses COVID-19 vaccines Enzymes Fertility In vitro fertilization Infections Infectious Disease Infertility Menstruation Morphology Motility Obstetrics/Gynecology Ovaries Pandemics Reproductive technologies Sperm Ultrasonic imaging Uterus |
| title | Transient Premature Ovarian Insufficiency Post-COVID-19 Infection |
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