Real-world progression-free survival (rwPFS) and the impact of PD-L1 and smoking in driver-mutated non-small cell lung cancer (NSCLC) treated with immunotherapy

Purpose Prior data suggest driver-mutated NSCLC, especially EGFR and ALK tumors, poorly respond to immunotherapy. However, little research using real-world cohorts have been performed, nor is it clear whether PD-L1 and smoking history are predictive of outcomes in such tumors. This study assessed rw...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 2023-05, Vol.149 (5), p.1755-1763
Hauptverfasser:	Bodor, J. Nicholas, Bauman, Jessica R., Handorf, Elizabeth A., Ross, Eric A., Clapper, Margie L., Treat, Joseph
Format:	Artikel
Sprache:	eng
Schlagworte:	B7-H1 Antigen - metabolism Cancer Research Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - therapy Epidermal growth factor receptors ErbB Receptors - genetics ErbB Receptors - metabolism Hematology Humans Immunotherapy Internal Medicine K-Ras protein Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - therapy Medicine Medicine & Public Health Mutation Non-small cell lung carcinoma Oncology Original Article – Clinical Oncology PD-1 protein PD-L1 protein Progression-Free Survival Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins p21(ras) - genetics Receptor Protein-Tyrosine Kinases - genetics Small cell lung carcinoma Smoking Tumors
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