Research overview of L-DOPA production using a bacterial enzyme, tyrosine phenol-lyase
L-DOPA is an amino acid that is used as a treatment for Parkinson’s disease. A simple enzymatic synthesis method of L-DOPA had been developed using bacterial L-tyrosine phenol-lyase (Tpl). This review describes research on screening of bacterial strains, culture conditions, properties of the enzyme,...
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| Veröffentlicht in: | Proceedings of the Japan Academy Series B, 2023/03/10, Vol.99(3), pp.75-101 |
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| container_title | Proceedings of the Japan Academy |
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| creator | KUMAGAI, Hidehiko KATAYAMA, Takane KOYANAGI, Takashi SUZUKI, Hideyuki |
| description | L-DOPA is an amino acid that is used as a treatment for Parkinson’s disease. A simple enzymatic synthesis method of L-DOPA had been developed using bacterial L-tyrosine phenol-lyase (Tpl). This review describes research on screening of bacterial strains, culture conditions, properties of the enzyme, reaction mechanism of the enzyme, and the reaction conditions for the production of L-DOPA. Furthermore, molecular bleeding of constitutively Tpl-overproducing strains is described, which were developed based on mutations in a DNA binding protein, TyrR, which controls the induction of tpl gene expression. |
| doi_str_mv | 10.2183/pjab.99.006 |
| format | Article |
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A simple enzymatic synthesis method of L-DOPA had been developed using bacterial L-tyrosine phenol-lyase (Tpl). This review describes research on screening of bacterial strains, culture conditions, properties of the enzyme, reaction mechanism of the enzyme, and the reaction conditions for the production of L-DOPA. Furthermore, molecular bleeding of constitutively Tpl-overproducing strains is described, which were developed based on mutations in a DNA binding protein, TyrR, which controls the induction of tpl gene expression.</description><identifier>ISSN: 0386-2208</identifier><identifier>ISSN: 0021-4280</identifier><identifier>EISSN: 1349-2896</identifier><identifier>DOI: 10.2183/pjab.99.006</identifier><identifier>PMID: 36908174</identifier><language>eng</language><publisher>Japan: The Japan Academy</publisher><subject>Amino acids ; Ammonia ; Bacteria ; Blood-brain barrier ; Brain research ; Dihydroxyphenylalanine ; Dopamine ; E coli ; Enzymatic synthesis ; Enzymes ; Erwinia herbicola ; Escherichia intermedia ; Food additives industry ; Gene expression ; Genes ; Industrial production ; Investigations ; L-DOPA ; Laboratories ; Levodopa ; Microorganisms ; Movement disorders ; Mutation ; Neurodegenerative diseases ; Parkinson's disease ; Phenols ; Protein binding ; Proteins ; Reaction mechanisms ; Review ; Strains (organisms) ; Tpl gene ; Tyrosine ; Tyrosine phenol-lyase ; Tyrosine Phenol-Lyase - genetics ; Tyrosine Phenol-Lyase - metabolism ; TyrR</subject><ispartof>Proceedings of the Japan Academy, Series B, 2023/03/10, Vol.99(3), pp.75-101</ispartof><rights>2023 The Author(s).</rights><rights>COPYRIGHT 2023 The Japan Academy</rights><rights>Copyright The Japan Academy Mar 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c672t-7ca9500c5eaabd6a7efda23790b71631a0c79bcb2b78084a5ecc79b96b6a117f3</cites><orcidid>0000-0003-0323-7196 ; 0000-0003-3688-0022 ; 0000-0003-4009-7874 ; 0000-0003-2464-3249</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170061/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10170061/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1882,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36908174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUMAGAI, Hidehiko</creatorcontrib><creatorcontrib>KATAYAMA, Takane</creatorcontrib><creatorcontrib>KOYANAGI, Takashi</creatorcontrib><creatorcontrib>SUZUKI, Hideyuki</creatorcontrib><title>Research overview of L-DOPA production using a bacterial enzyme, tyrosine phenol-lyase</title><title>Proceedings of the Japan Academy</title><addtitle>Proc. Jpn. Acad., Ser. B</addtitle><description>L-DOPA is an amino acid that is used as a treatment for Parkinson’s disease. A simple enzymatic synthesis method of L-DOPA had been developed using bacterial L-tyrosine phenol-lyase (Tpl). This review describes research on screening of bacterial strains, culture conditions, properties of the enzyme, reaction mechanism of the enzyme, and the reaction conditions for the production of L-DOPA. Furthermore, molecular bleeding of constitutively Tpl-overproducing strains is described, which were developed based on mutations in a DNA binding protein, TyrR, which controls the induction of tpl gene expression.</description><subject>Amino acids</subject><subject>Ammonia</subject><subject>Bacteria</subject><subject>Blood-brain barrier</subject><subject>Brain research</subject><subject>Dihydroxyphenylalanine</subject><subject>Dopamine</subject><subject>E coli</subject><subject>Enzymatic synthesis</subject><subject>Enzymes</subject><subject>Erwinia herbicola</subject><subject>Escherichia intermedia</subject><subject>Food additives industry</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Industrial production</subject><subject>Investigations</subject><subject>L-DOPA</subject><subject>Laboratories</subject><subject>Levodopa</subject><subject>Microorganisms</subject><subject>Movement disorders</subject><subject>Mutation</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson's disease</subject><subject>Phenols</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Reaction mechanisms</subject><subject>Review</subject><subject>Strains (organisms)</subject><subject>Tpl gene</subject><subject>Tyrosine</subject><subject>Tyrosine phenol-lyase</subject><subject>Tyrosine Phenol-Lyase - 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| source | J-STAGE Free; MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Project Euclid Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Amino acids Ammonia Bacteria Blood-brain barrier Brain research Dihydroxyphenylalanine Dopamine E coli Enzymatic synthesis Enzymes Erwinia herbicola Escherichia intermedia Food additives industry Gene expression Genes Industrial production Investigations L-DOPA Laboratories Levodopa Microorganisms Movement disorders Mutation Neurodegenerative diseases Parkinson's disease Phenols Protein binding Proteins Reaction mechanisms Review Strains (organisms) Tpl gene Tyrosine Tyrosine phenol-lyase Tyrosine Phenol-Lyase - genetics Tyrosine Phenol-Lyase - metabolism TyrR |
| title | Research overview of L-DOPA production using a bacterial enzyme, tyrosine phenol-lyase |
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