Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation

Hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) have robust self-renewal potential, which is responsible for sustaining normal and malignant hematopoiesis, respectively. Although considerable efforts have been made to explore the regulation of HSC and LSC maintenance, the underlying m...

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Veröffentlicht in:	Leukemia 2023-05, Vol.37 (5), p.1039-1047
Hauptverfasser:	Lu, Yukai, Yang, Lijing, Shen, Mingqiang, Zhang, Zihao, Wang, Song, Chen, Fang, Chen, Naicheng, Xu, Yang, Zeng, Hao, Chen, Mo, Chen, Shilei, Wang, Fengchao, Hu, Mengjia, Wang, Junping
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/109 13/31 13/95 14/19 38/1 38/90 38/91 631/532/1542 631/532/71 631/67/1990/283/1897 64/110 64/60 Acute myeloid leukemia Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals c-Myc protein Cancer Research Cell self-renewal Clonal selection Critical Care Medicine Degradation Hematology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Hemopoiesis Humans Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - pathology Leukemogenesis Maintenance Medicine Medicine & Public Health Mice Molecular modelling Myc protein Neoplastic Stem Cells - pathology Oncology Positive selection Stem cells Thymocytes - pathology Ubiquitination
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