Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms

•Characterizing genetic regulation of tryptase expression redefines clinical laboratory reference ranges based on TPSAB1 replication number.•Individualized reference values for serum tryptase change and improve the utility of this biomarker in the diagnosis of myeloid neoplasms. [Display omitted] Se...

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Veröffentlicht in:	Blood advances 2023-05, Vol.7 (9), p.1796-1810
Hauptverfasser:	Chovanec, Jack, Tunc, Ilker, Hughes, Jason, Halstead, Joseph, Mateja, Allyson, Liu, Yihui, O’Connell, Michael P., Kim, Jiwon, Park, Young Hwan, Wang, Qinlu, Le, Quang, Pirooznia, Mehdi, Trivedi, Neil N., Bai, Yun, Yin, Yuzhi, Hsu, Amy P., McElwee, Joshua, Lassiter, Sheryce, Nelson, Celeste, Bandoh, Judy, DiMaggio, Thomas, Šelb, Julij, Rijavec, Matija, Carter, Melody C., Komarow, Hirsh D., Sabato, Vito, Steinberg, Joshua, Hafer, Kurt M., Feuille, Elizabeth, Hourigan, Christopher S., Lack, Justin, Khoury, Paneez, Maric, Irina, Zanotti, Roberta, Bonadonna, Patrizia, Schwartz, Lawrence B., Milner, Joshua D., Glover, Sarah C., Ebo, Didier G., Korošec, Peter, Caughey, George H., Brittain, Erica H., Busby, Ben, Metcalfe, Dean D., Lyons, Jonathan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Mast Cells Mastocytosis - diagnosis Myeloid Neoplasia Myeloproliferative Disorders - pathology Reference Values Tryptases - genetics Unnecessary Procedures
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