Mychonastes sp. 246 Suppresses Human Pancreatic Cancer Cell Growth via IGFBP3-PI3K-mTOR Signaling

Previously, we confirmed that sp. 246 methanolic extract (ME) markedly reduced the viability of BxPC-3 human pancreatic cancer cells. However, the underlying mechanism ME remained unclear. Hence, we attempted to elucidate the anticancer effect of ME on BxPC-3 human pancreatic cancer cells. First, we...

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Veröffentlicht in:	Journal of microbiology and biotechnology 2023-04, Vol.33 (4), p.449-462
Hauptverfasser:	Jang, Hyun-Jin, Lee, Soon, Hong, Eunmi, Yim, Kyung June, Choi, Yong-Soo, Jung, Ji Young, Kim, Z-Hun
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell Line, Tumor Cell Movement - genetics Cell Proliferation Humans Insulin-Like Growth Factor Binding Protein 3 - metabolism Insulin-Like Growth Factor Binding Protein 3 - pharmacology Pancreatic Neoplasms Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Research article Signal Transduction TOR Serine-Threonine Kinases - metabolism TOR Serine-Threonine Kinases - pharmacology
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